Garuda - Garba Rujukan Digital

Alex Chairulfatah

Unknown Affiliation

Author-ID : 3459957

Health Professions Medicine & Pharmacology

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Serum zinc levels and clinical severity of dengue infection in children Nuke Yuliana; RM Ryadi Fadil; Alex Chairulfatah
Paediatrica Indonesiana Vol 49 No 6 (2009): November 2009
Publisher : Indonesian Pediatric Society

Background Immunopathogenesis of dengue infection revealsthe aberrant immune response. Zinc deficiency alters immuneresponse and therefore may associated with clinical severity ofdengue infection.Objective To indentifY the relationship between serum zinc levels and clinical severity of dengue infection in children.Methods A comparative study was conducted at the Departmentof Child Health Hasan Sadikin Hospital Bandung, from Februaryto March 2007. We included children aged ~ 14 years fulfilled theclinical criteria for dengue fever (OF), dengue hemorrhagic fever(DHF), and dengue shock syndrome (DSS) according to WHO(1997), confirmed with serologic test. Subjects were selectedconsecutively until met the sample size for each group. Serumzinc level were measured with atomic absorption spectroscopy(MS) on admission. Data were analyzed using Kruskal-Wallis andPearson chi square test. Significance was considered if P<0.05.Results The serum zinc levels were low in 47 (78.3%) children.The serum zinc level in OF, DHF, and DSS subjects were 56-81 (XÂ±SO= 68.2Â±8.3) J.Lg/dL; 50-77 (XÂ± SO = 61.6 Â± 8. 7) J.Lg/dL;and35-52 (XÂ± SO= 42.7 Â± 5.4) j.tg/dL, respectively (P<0.001).The prevalence ratio ofDF to DHF and DHF to DSS were 1.444(P=0.311) and 3.353 (P=0.077), respectively.Conclusion Low serum zinc level were significantly different ineach clinical severity of dengue infection. However, low serum zinc level was not a risk factor for the development of severe dengue infection in children.

Giardiasis in daycare centers at Rancabali tea plantation, Bandung District, Indonesia Endang Widajanti; Herry Garna; Alex Chairulfatah; Dadang Hudaya
Paediatrica Indonesiana Vol 43 No 5 (2003): September 2003
Publisher : Indonesian Pediatric Society

Background In developing countries, the prevalence of giardia-sis in daycare centers is considerably high. There had been inad-equate report of giardiasis in Indonesia.Objective To know the prevalence of giardiasis in children andthe number of children with symptomatic and asymptomatic giar-diasis who attended daycare centers at Rancabali tea plantation,Bandung district.Methods This descriptive study was conducted in daycare cen-ters between August to October 2002. Giardiasis was defined asthe occurrence of G. lamblia cyst in stool specimen independentfrom the presence or absence of symptoms. Four of 12 daycarecenters were chosen by cluster random sampling. All children aged1 to 60 months attending daycare and staying for at least 2 weekswere included in this study. Three consecutive stool specimen pre-served by 10% formalin, concentrated by formalin ether, were ex-amined microscopically to find the G. lamblia cyst.Results Giardia lamblia cysts were found in 27 (29%) of the 92children attending the daycare centers at Rancabali tea plantation(95%CI 20;38.6%). Of these children, 15 showed symptoms suchas diarrhea episodes (8 children), diarrhea (5 children), bloating (5children), abdominal cramp (5 children), and vomiting (3 children).Three children showed mild to moderate malnutrition. Ten childrenaged 13 to 36 month-old with G. lamblia-positive stool showed suchsymptoms.Conclusion The prevalence of G. lamblia infection in children at-tending daycare centers at Rancabali tea plantation was almostsimilar with other place in developing countries. More than half ofpatients had symptomatic disease

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