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Ponpon Ijradinata
Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin Hospital, Bandung, West Java
Health Professions Medicine & Pharmacology

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NPHS2 gene mutation, atopy, and gender as risk factors for steroid-resistant nephrotic syndrome in Indonesians Dedi Rachmadi; Danny Hilmanto; Ponpon Ijradinata; Abdurahman Sukadi
Paediatrica Indonesiana Vol 51 No 5 (2011): September 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.237 KB) | DOI: 10.14238/pi51.5.2011.272-6

Abstract

Background Steroid-resistant nephrotic syndrome (SRNS) often develops into end stage renal disease. Previous studies have reported that NPHS2 gene mutation, gender, and atopic history are risk factors associated with SRNS. Interethnic, sociocultural, and environmental differences have also been suggested to affect these mutations.Objective To analyze possible risk factors for SRNS, including NPHS2 gene mutations (412C→T and 419delG), gender and atopic history, in Indonesian subjects with SRNS.Methods A case-control study with 153 subjects, consisting of 88 SRNS patients and 65 control subjects, was undertaken in 10 Indonesian teaching centre hospitals from September 2006 to December 2007. Analysis of the NPHS2 gene mutation in 412 C→T was performed by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR), while that for the NPHS2 gene mutation in 419delG was performed by restriction fragment length polymorphism (RFLP). Data was analyzed by multiple logistic regression.Results In our Indonesian subjects, the significant risk factors for SRNS were male gender (OR=2.21; CI 95%:1.07-4.56, P=0.036), NPHS2 412C→T gene mutation (OR=18.07; CI 95%:6.76-48.31, P<0.001), and NPHS2 419delG gene mutation (OR=4.55; CI 95%:1.66-12.47, P=0.003). However, atopic history was not a significant risk factor for SRNS (OR=1.807; CI 95%:0.642-5.086, P=0.262).Conclusion NPHS2 412C→T and 419delG gene mutations, as well as male gender are risk factors for SRNS in Indonesian subjects. Atopic history was not significantly associated with SRNS in our subjects. [Paediatr Indones. 2011;51:272-6].
Renal tubular function of the child with thalassemia major who received repeated blood trransfusion Dany Hilmanto; Boed Sinai Singadipoera; Ponpon Ijradinata
Paediatrica Indonesiana Vol 39 No 7-8 (1999): July - August 1999
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.391 KB) | DOI: 10.14238/pi39.7-8.1999.193-200

Abstract

A descriptive study was done from December 2 , 1994 to January 5,1995, at the Department of Child Health of Hasan Sadikin General Hospital Bandung. A total of 50 thalassemia major patients who bad received 5,000 ml or more of blood transfusions and never received desfenioxamine underwent a renal tubular function test using a radionuclide technique (l-123 Hippuran) to determine the effective renalplasmft flow (ERPF). The subjects were div:ided into two groups according to the amount of transfusion. Group A who received a total of 5,000 to 10,000 mL of blood transfusion consisted of 23 children (11 boys and 12 girls); group B, those who received a total of 10,000 ml or more of blood transfusion, consisted of 27 children (14 boys and 13 girls). The total average of blood transfused for group A and B were 7563.91 (1780.59) and 20,665.93 (6632.39) rnl, respectively. The ERPF of all subjects were below the normal standard. The average value of ERPF of group A and B were 205.78 (62 .08) and 214.09 (59.44) ml/minute/1.73 m2, respectively. The correlation between the total amount of blood transfusion and ERPF of the subjects was not significant (Group A had r=O.l63, p=0.458; Group B had r=0.084, p=0 .934).
Normal Hemoglobin Values in 12-24 Month Old Children Zahedi Affandi; Harry Respati; Ponpon Ijradinata
Paediatrica Indonesiana Vol 35 No 1-2 (1995): January - February 1995
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (574.346 KB) | DOI: 10.14238/pi35.1-2.1995.18-22

Abstract

One hundred and thirty-one children aged 12 to 24 months attending the Under Five Clinic of The Department of Child Health, Medical School, Padjadjaran University/Hasan Sadikin General Hospital in Bandung were studied. These subjects were "healthy" and they had no laboratory evidence neither of folic acid, vitamin B12 or iron deficiency, nor thalassemia minor, and/or hemoglobinopathy. These individuals were considered adequately nourished from the erithropoietic point of view, and they constituted the "normal" subjects from which values of hemoglobin were calculated. Results from this highly selected subjects indicated that the mean hemoglobin value was 127.2 g/L (range: 111.6-142.8 g/L). The lower limit of the hemoglobin value in this study is within the normal range according to the WHO criteria for normal hemoglobin values in children 6 months to 6 years of age.
Effects of Iron Supplementation on Hemoglobin Concentration in 12-18 Month Old Iron-Deficient Anemic Infants Iskandar Iskandar; Nono Sumarna Afandi; Ponpon Ijradinata
Paediatrica Indonesiana Vol 34 No 7-8 (1994): July - August 1994
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (693.334 KB) | DOI: 10.14238/pi34.7-8.1994.179-86

Abstract

A randomized double blind clinical trial was conducted to study the effects of iron supplementation on hemoglobin values of 97 iron-deficient anemic (DA) and iron-sufficient (IS) infants, 12 to 18 months of age. IDA (n=SO) infants were assigned randomly to either receive dietary ferrous sulfate or placebo for 4 months. Similar treatment randomization was done among IS (n=4 7) infants. Before intervention, the mean hemoglobin value of the IDA infants was significantly (p<0.01) lower than that of the IS group. After intervention, there was an increase in the hemoglobin values of the IDA infants who had received iron, and was significantly (p<0.01) higher than those of the placebo treated IDA group, lS group, as well as placebo treated IS group. Hemoglobin values of the IDA infants who had received iron, increased up to the normal level as refer to the WHO's criteria used for normal hemoglobin values.
Co-Authors Abdurahman Sukadi Boed Sinai Singadipoera Danny Hilmanto Dany Hilmanto Dedi Rachmadi Harry Respati Iskandar Iskandar Nono Sumarna Afandi Zahedi Affandi