Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Paediatrica Indonesiana The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Rustadi Sosrosumihardjo
Unknown Affiliation
Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Morphology and disaccharidase activity of small intes- tinal mucosa in post-weaning-induced malnourished rats and after realimentation Rustadi Sosrosumihardjo; Agus Firmansyah; Asri Rasad; Daldiyono Harjodisastro; Endi Ridwan; Septilia Inawati Wanandi; Dwirini Retno
Paediatrica Indonesiana Vol 46 No 5 (2006): September 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.995 KB) | DOI: 10.14238/pi46.5.2006.229-35

Abstract

Background The most common cause of failure to thrive in in-fants is malnutrition which causes histological and biochemicalchanges of small intestine. Studies on histology and enzyme ac-tivity of small intestinal mucosa were not much developed.Objective To study about histology and disaccharidases activity ofsmall intestinal mucosa in post-weaning-induced malnourished rats.Methods We used Sprague-Dawley white rats as the subjects ofthis study with post test-control group design. The study was per-formed at the CentER for Research of Food and Nutrition Devel-opment from April 2003 to December 2004.Results There were a decrease of body weight (hypotrophy nor-moblastic) and an increase of disaccharidase activity of small in-testinal mucosa in post-weaning-induced malnourished rats. Afterrealimentation, there were an increase of body weight, an improve-ment of the hypotrophy, and a decrease of the enzyme but theystill cannot reach normal condition.Conclusion In malnourished rats, there are decrease of bodyweight hypotrophy normoblastic and increase of disaccharidasesactivity of intestinal mucosa that are improved after realimentation
Laboratorium Diagnosis of Clostridium difficile Infection Grace Nerry Legoh; Rustadi Sosrosumihardjo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 2, August 2006
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/72200646-50

Abstract

Clostridium difficile is the most important cause of antibiotic associated diarrhea, and pseudomembranous colitis, a severe infection of the colon. Strain Clostridium difficile produce two potent toxin, toxin A (enterotoxin) and toxin B (cytotoxin). These two toxins are both responsible for the diarrhoea and inflammation seen in patients treated due to infection, especially the broad spectrum antibiotics. Direct detection of Clostridium difficile cytotoxin from faecal specimen using mammalian tissue culture lines is considered the standard diagnostics test of Clostridium difficile infection. This test is very sensitive but requires a minimum two days to complete. In order to improve the threshold of diagnosis and treatment, a number of enzyme immunoassay Methods have been used, with a reported sensitivity to either toxin A or toxin B. Keywords: Clostridium difficile, cytotoxin, diarrhea, enzyme immunoassay
Co-Authors Agus Firmansyah Asri Rasad Daldiyono Harjodisastro Dwirini Retno Gunarti Endi Ridwan Grace Nerry Legoh Septilia Inawati Wanandi