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Sofyan Ismael

Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta

Author-ID : 3473046

Health Professions Medicine & Pharmacology

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Articles

A Case of Rett Syndrome Samuel Lazuardi; Najib Advani; Sofyan Ismael
Paediatrica Indonesiana Vol 29 No 11-12 (1989): November - December 1989
Publisher : Indonesian Pediatric Society

A case of Rett syndrome in a-3 Â½ year-old girl is presented. The patient had normal pre and perinatal period and normal psychomotor development till the age of 14 months, followed by behavioural, social and psychomotor regression. Physical examination revealed a below normal head circumference, loss of eye and psychic contact, stereotypic hand movements and gait disturbance. No laboratory test can confirm the diagnosis of Rett syndrome, therefore the diagnosis was established by virtue of history of illness and clinical manifestations. This is the first case of Rett syndrome found and reported in Indonesia.

The Efficacy of Once-Daily Dose of Phenobarbital in Children with Generalized Tonic-Clonic Epilepsy Amril A. Burhany; Sofyan Ismael; Hardiono Pusponegoro
Paediatrica Indonesiana Vol 35 No 7-8 (1995): July - August 1995
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi35.7-8.1995.172-9

In spite of its long half life, phenobarbital is still given twice-daily in the treatment of generalized tonic-clonic epilepsy. This study aims to determine if daily dose of phenobarbital given once differs to that given twice daily. Subjects of this unblinded controlled clinical trial were generalized tonic-clonic epilepsy patients ranging in age from 1-15 years. There were 40 study cases and 42 controls. We gave phenobarbital 4-6 mg/kg/day once-daily for study group and twice-daily dose for control group. History, physical and EEG examination and phenobarbital plasma measurements were obtained a t the beginning of the study and four weeks later. The ratio of the second to first phenobarbital plasma concentrations in the study group was 0.99 while in the control group it was 1.02. The proportion of seizure-free patients in the study group increased from 70% at the beginning to 85% at the end of study, and in the control group from 64.3% to 83.3%. Hyperactivity and irritability increased in both groups, and there were no significant differences in mean serum levels, seizures control, hyperactivity and irritability in both groups. Drowsiness was found in 50% of cases, but statistically significant decrease were found in study group. The compliance of the study group (92.5%) was significantly better than that of the control group (71.4%).

Diagnosis and Management of Brain Tumors in Children Taslim S. Soetomenggolo; Hardiono Pusponegoro; Jimmy Passat; Dwi Putro Widodo; Sofyan Ismael
Paediatrica Indonesiana Vol 35 No 7-8 (1995): July - August 1995
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi35.7-8.1995.185-9

Brain tumors are the second most common malignancy and the most common solid tumors found in childhood. During 11 months 19 patients with brain tumors were hospitalized at the Department of Child Health, Dr. Cipto Mangunkusurno Hospital, Jakarta, 10 of them were males. The youngest patient was 5 months old and the oldest was 13 years old. The important signs and symptoms in establishing diagnosis were the non-localizing signs and symptoms, i.e., nausea and vomiting. The most frequent localizing signs and symptoms were papilledema, cranial nerves palsy, ataxia and incoordination, hemiparesis, visual disturbances, and optic atrophy. Focal seizures were rare. Most of the tumors were in infratentorial region, and metastatic tumors were rare. The mortality of this series was high due to the severity of the disease. The most frequent of tumors are astrocytomas and medulloblastomas.

Blood Gas Analysis in Neonatal Tetanus Taslim S. Soetomenggolo; Dwi Putro Widodo; Jimmy Passat; Sofyan Ismael
Paediatrica Indonesiana Vol 34 No 1-2 (1994): January - February 1994
Publisher : Indonesian Pediatric Society

We reviewed the results of arterial blood gas analysis in 127 patients with neonatal tetanus on admission, and in 52 of such patients on the day before they died. All patients were hospitalized at the Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta. On admission, most patients showed uncompensated metabolic acidosis. The mortality of patients wjth pH ofless than 7 was 100%. There was no significant difference between the mortality of patients with pH 7.35-7.45 and those with pH of less than 7.35. Analysis of acid-base balance indicated that ventilatory fw1ure was the most common finding in 52 patients who subsequently died. We recommend using intravenous fluid containing a combination of 5% dextrose and sodium bicarbonate with 4 : 1 (vol/vol) ratio from the fust day of hospitalization to reduce the possibility of the development of ongoing metabolic acidosis in patients with neonatal tetanus. Maintaining adequate ventilation is mandatory ln such patients.

Evaluation of Mortality of Patients with Neonatal Tetanus Taslim S. Soetomenggolo; Hardiono D. Pusponegoro; Jimmy Passat; Sofyan Ismael
Paediatrica Indonesiana Vol 34 No 5-6 (1994): May - June 1994
Publisher : Indonesian Pediatric Society

During 8 years, 405 patients of neonatal tetanus were hospitalized in the Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta. Diagnosis of neonatal tetanus was based on clinical signs and symptoms. Of the 405 patients, 56.3% were males and 43.7 %. were females. Two hundreds and sixty nine (66.3 %) patients were delivered by traditional birth attendants, and only 33.6% were delivered by midwives or physicians. The overall mortality was 54.4%, with the corrected mortality of 46.7%. Severity of the disease, short incubation period, short period of onset, and the accompanying diseases were responsible for the high mortality of patients with neonatal tetanus.

Diagnosis and Management of Brain Abscesses in Children Taslim S. Soetomenggolo; Jimmy Passat; Hardiono D. Pusponegoro; Sofyan Ismael
Paediatrica Indonesiana Vol 32 No 5-6 (1992): May - June 1992
Publisher : Indonesian Pediatric Society

During 4 years, 20 patients with brain abscesses were hospitalized in the Departement of Child Health, Dr. Cipto Mangunkusumo General Hospital, jakarta. Of those 20 patients 11 were males and 9 were females. The youngest patient was 2 months old and the oldest was 12 years old. The important signs and symptoms in making diagnosis were the sign of injection, increased intracranial pressure, and focal neurological disorders. Laboratory examinations were of little value in establishing the diagnosls of brain abscess. By performing head CT Scan the diagnosis of brain abscess will be confirmed accurately. Of the 20 patients, 15 (75 %) suffered from single abscess and 5 (25 %) suffered from multiple abscesses. The results of treatment by surgical intervention were better than nonsurgical treatment. The high mortallty of the nonsurgical patients was caused by the severity of the disease due to the ignorancy of their parent.

Co-Authors Amril A. Burhany Dwi Putro Widodo Hardiono D. Pusponegoro Hardiono Pusponegoro Jimmy Passat Najib Advani Samuel Lazuardi Taslim S. Soetomenggolo

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