Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Paediatrica Indonesiana
Hardiono Pusponegoro
Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Efficacy of Once-Daily Dose of Phenobarbital in Children with Generalized Tonic-Clonic Epilepsy Amril A. Burhany; Sofyan Ismael; Hardiono Pusponegoro
Paediatrica Indonesiana Vol 35 No 7-8 (1995): July - August 1995
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi35.7-8.1995.172-9

Abstract

In spite of its long half life, phenobarbital is still given twice-daily in the treatment of generalized tonic-clonic epilepsy. This study aims to determine if daily dose of phenobarbital given once differs to that given twice daily. Subjects of this unblinded controlled clinical trial were generalized tonic-clonic epilepsy patients ranging in age from 1-15 years. There were 40 study cases and 42 controls. We gave phenobarbital 4-6 mg/kg/day once-daily for study group and twice-daily dose for control group. History, physical and EEG examination and phenobarbital plasma measurements were obtained a t the beginning of the study and four weeks later. The ratio of the second to first phenobarbital plasma concentrations in the study group was 0.99 while in the control group it was 1.02. The proportion of seizure-free patients in the study group increased from 70% at the beginning to 85% at the end of study, and in the control group from 64.3% to 83.3%. Hyperactivity and irritability increased in both groups, and there were no significant differences in mean serum levels, seizures control, hyperactivity and irritability in both groups. Drowsiness was found in 50% of cases, but statistically significant decrease were found in study group. The compliance of the study group (92.5%) was significantly better than that of the control group (71.4%).
Diagnosis and Management of Brain Tumors in Children Taslim S. Soetomenggolo; Hardiono Pusponegoro; Jimmy Passat; Dwi Putro Widodo; Sofyan Ismael
Paediatrica Indonesiana Vol 35 No 7-8 (1995): July - August 1995
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi35.7-8.1995.185-9

Abstract

Brain tumors are the second most common malignancy and the most common solid tumors found in childhood. During 11 months 19 patients with brain tumors were hospitalized at the Department of Child Health, Dr. Cipto Mangunkusurno Hospital, Jakarta, 10 of them were males. The youngest patient was 5 months old and the oldest was 13 years old. The important signs and symptoms in establishing diagnosis were the non-localizing signs and symptoms, i.e., nausea and vomiting. The most frequent localizing signs and symptoms were papilledema, cranial nerves palsy, ataxia and incoordination, hemiparesis, visual disturbances, and optic atrophy. Focal seizures were rare. Most of the tumors were in infratentorial region, and metastatic tumors were rare. The mortality of this series was high due to the severity of the disease. The most frequent of tumors are astrocytomas and medulloblastomas.
Co-Authors Amril A. Burhany Dwi Putro Widodo Jimmy Passat Sofyan Ismael Taslim S. Soetomenggolo