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Hendra Santoso
Department of Child Health, Universitas Udayana Medical School/Sanglah Hospital, Denpasar, Bali
Health Professions Medicine & Pharmacology

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Food Hypersensitivity as a Cause of Atopic Dermatitis Hendra Santoso
Paediatrica Indonesiana Vol 34 No 5-6 (1994): May - June 1994
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (602.687 KB) | DOI: 10.14238/pi34.5-6.1994.129-35

Abstract

Thirty children from infancy to 12 years suffering from atopic dermatitis were evaluated for food hypersensitivity by means of history, skin prick test, total eosinophils count, and elimination of suspected food. Sixteen (53%) patients had history of allergy to suspected food, the other 16 (53%) had ether allergic diseases. Of the 30 patients, 15 (50%) had one of the parents with allergic diseases, and in 3 patients both parents suffered from a1Iergic diseases. Nineteen (6:3-1.) children had atopic dermatitis triggered by food; egg accounted for 400/o, fish for 53-lo and shrimp for 40% for the allergic manifestations. Skin prick test consisted of 20 food allergens was done to all children above 2 years of age, 12 (40%) of the pa1ients showed positive results. This study demonstrated that food hypersensitivity may play a pathogenic role in some children with atopic dermatitis. Appropriate diagnosis and restriction of diet can improve their skin symptoms.
Cystatin C level and amikacin use in neonatal sepsis Putu Diah Pratiwi; I Wayan Dharma Artana; Ni Putu Veny Kartika Yantie; Hendra Santoso; I Gusti Ngurah Sanjaya Putra; Gusti Ayu Putu Nilawati; Ni Nyoman Metriani Nesa
Paediatrica Indonesiana Vol 60 No 1 (2020): January 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.997 KB) | DOI: 10.14238/pi60.1.2020.1-5

Abstract

Background Amikacin is the antibiotic of choice for eradicating bacteria in neonatal sepsis because of its effectiveness against Gram-negative bacteria. However, this drug has nephrotoxic effects. Monitoring kidney function in neonates is very important because amikacin can interfere with development of the kidney. Several studies have shown that serum cystatin C levels were closer to glomerular filtration rate (GFR) values ​​compared to serum creatinine levels. Objective To evaluate cystatin C levels before and after administration of amikacin in neonates with sepsis. Methods This prospective cohort study was conducted in one group with a pretest and posttest design. Thirty neonatal sepsis patients who received amikacin therapy at Sanglah General Hospital, Denpasar, Bali, were included by consecutive sampling. Their cystatin C levels were measured before and after receiving amikacin therapy. Data were normally distributed and analyzed by paired T-test, with a value of P<0.05 considered to be significant. Results The mean difference was 0.23 [1.57 (SD 0.29) vs. 1.80 (SD 0.28)] mg/L with P value < 0.001. There was different value of cystatin c level before and after amikacin therapy with deviation standard 0.25 with P<0.001 (alfa 5%). Conclusion Cystatin C levels are significantly higher in neonates with sepsis after administration of amikacin.
Co-Authors Gusti Ayu Putu Nilawati I Gusti Ngurah Sanjaya Putra I Wayan Dharma Artana Ni Nyoman Metriani Nesa NP Veny Kartika Yantie Putu Diah Pratiwi