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I. G. N. Wila Wirya
Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
Health Professions Medicine & Pharmacology

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A Clinico-Pathological Correlation of Childhood Primary Nephrotic Syndrome in Jakarta I. G. N. Wila Wirya
Paediatrica Indonesiana Vol 33 No 7-8 (1993): July - August 1993
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (706.215 KB) | DOI: 10.14238/pi33.7-8.1993.150-8

Abstract

Three hundred and sixty-four out of 547 children with primary nephrotic syndrome (PNS) treated at the Department of Child Health, Medical School, University of Indonesia between January 1970 and December 1979, were biopsied. The clinical, laboratory, and pathological characteristics of these patients were evaluated and compared with those reported by the International Study of Kidney Disease in Children (ISKOC, 1978) comprising children of Western countries with PNS. Results of this study showed that the spectrum of the histopathological changes in the 2 study populations was slightly different. Clinical and laboratory characteristics of certain types of PNS also showed some differences compared with those of ISKDC report. Patients with non-minimal changes nephrotic syndrome (NMCNS) were more frequently found in this study, and they were older than those of ISKDC report, i.e., more children < 6 years of age were affected with this disease in Jakarta. Similarly, this study showed that patients with minimal changes nephrotic syndrome (MCNS) were older than those of ISKDC report; the peak age of Western patients was less than 6 years. Patients with focal segmental glomerulosclerosis (FSGS) and membranoproliferative glomerulonephritis (MPGN) reported by ISKDC were more severe than those of this study as far as clinical and laboratory characteristics were concerned. The causes of these clinical and histopathological discrepancies between the two studies need to be further elucidated.
Studies of Blood Pressure and Prevalence of Hypertension in Schoolchildren in Jakarta I. G. N. Wila Wirya; Husein Alatan; Taralan Tambunan; S. Harmanses; Endang Windiastuti
Paediatrica Indonesiana Vol 28 No 9-10 (1988): September - October 1988
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (455.088 KB) | DOI: 10.14238/pi28.9-10.1988.183-91

Abstract

Blood pressure measurement was done on 4983 school children of 6 - 18 years schoolchildren was at random so that the sample population represented the children in Jakarta. The incidence of hypertension in this study is about 3.11 %, of which most are found at the age of 15 years.
Colloid Oncotic Pressure in Children with Nephrotic Syndrome Taralan Tambunan; H. Alatas; I. G. N. Wila Wirya; S. Harmanses; I. Chair; R. Simanjuntak
Paediatrica Indonesiana Vol 28 No 9-10 (1988): September - October 1988
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (581.566 KB) | DOI: 10.14238/pi28.9-10.1988.200-8

Abstract

To evaluate the correlation between plasma protein concentration and colloid oncotic pressure (COP) and their influence on clinical symptom of edema, we studied 30 children with nephrotic syndrome (NS). Total plasma protein concentration (TP), albumm, globulin and COP were measured in all patients in edema forming state (EF) and m steady state phase (SS), except for COP, only 16 samples in SS phase. COP TP plasma albumin and globulin contents in EF group were 8. 7 ± 2. 7 mmHg, 4.07 '± 0.68 g/dl; 2.57 ± 0.50 g/dl and 1.51 ± 0.32 g/dl, respectively. In SS group these figures rose significantly to 16.7 ± 3.9 mmHg for COP; 5. 70 ± 0.99 g/dl for TP; 3.46 ± 0.52 g!dl and 2.06 ± 0.56 g/dl for plasma albumin and globulin, respectively. We also found the high correlation both between COP and albumin content (r= +0.58; p < 0.01) and between COP and TP (r= +0.54; P < 0.01) . A strong negative correlation was also found between COP and the degree of edema (r = _ 0.55; p <0.01). On the other hand a very low grade correlation was noticed between plasma albumin content and the degree of edema (r= - 0.26; P < 0.05) and no correlation at all was found between edema and TP (r= - 0.19; P > 0.05). We conclude that COP has the highest correlation with plasma protein concentration and the degree of edema, and can be used as a diagnostic tool. It is even more sensitive and simple compared with the TP or albumin content determination.
Co-Authors Endang Windiastuti H. Alatas Husein Alatan I. Chair R. Simanjuntak S. Harmanses Taralan Tambunan