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All Journal JagoMIPA: Jurnal Pendidikan Matematika dan IPA Jurnal Pijar MIPA
Mahrun Mahrun
STKIP Al Amin Dompu
Biochemistry, Genetics & Molecular Biology Chemistry Education Mathematics Physics

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The effect of black rice (Oryza sativa L. Indica) extract to increase estrogen hormone on pre-menopause of female white rats (Rattus norvegicus) Ardiansyah Ardianyah; Mahrun Mahrun
Jurnal Pijar Mipa Vol. 17 No. 1 (2022): January 2022
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.329 KB) | DOI: 10.29303/jpm.v17i1.2467

Abstract

The study aimed to determine the estrogenic activity of extracting ethanol from black rice (Oryza Sativa L. Indica) in pre-menopausal female white rats (Rattus norvegicus). Adaptation was carried out on 20 female rats (Rattus norvegicus) experimental rats for one week with a body weight of about 200-250 g. After one week, the experimental rats were divided into five treatment groups, with each group consisting of 4 rats. The positive control group (P1) was given Ethinyl estradiol orally at a dose of 9×10-3 mg/ 200g BB in CMC-Na 1% as much as 3 mL. The negative control group (P2) was given orally CMC-Na 1% / 200g BW as 3 mL. Test Group I (P3) were given orally an extract of Black Glutinous Rice mixed with ethanolic basil leaves 96% with a dose equivalent to 1 mL of thick extract in an amount of 0.8g/200g BW in 1% CMC-Na as much as 3 mL. Test Group II (P4) was given an extract of the ethanol substance in Black Rice with a dose equivalent to 2 mL of thick extract in 1.6g/200g BW in 3 mL of 1% CMC-Na orally. Test Group III (P5) was given orally Black Glutinous Rice in a dose equivalent to 4 mL of thick extract in 3.2g/200g BB in CMC-Na 1% as much as 3 mL. The treatments were carried out orally for one estrous cycle begins during the estrus phase. Uniformity during the estrus phase was carried out using the Whitten-Method Effect. It aims to observe changes in the vagina to determine the estrus cycle by placing the male rat cage on top of the female rat cage. Conclusions from the results of this study show that the Black Glutinous Rice (Oryza Sativa L. Indica) extract treatment can increase the estrogenic activity of white rats pre-menopausal females (Rattus norvegicus). A 0.8g/200g BW dose can prolong the estrus cycle and increase vascularity and ovarian weight compared to the negative control (CMC-Na1%). The treatment with the lowest concentration was equivalent to the positive control of Ethinyl estradiol (9x10-3mg/200g BW). This test indicates that giving 96% ethanol extract of Black Glutinous Rice causes an increase in the hormone estrogen in the estrus phase, which tends to prolong the estrus cycle.
Pengembangan Alat Peraga Fisika Dasar Berbasis Konstruktivisme untuk Membangun Keterampilan Generik Sains pada Peserta didik SMA Ardiansyah Ardiansyah; Mahrun Mahrun; Purnamansyah Purnamansyah
JagoMIPA: Jurnal Pendidikan Matematika dan IPA Vol. 3 No. 1 (2023): JagoMIPA: Jurnal Pendidikan Matematika dan IPA, Edisi Januari - Juni 2023
Publisher : Yayasan Pendidikan Bima Berilmu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53299/jagomipa.v3i1.265

Abstract

Penelitian ini tergolong penelitian pengembangan, Penelitian dan Pengembangan. Metode penelitian dan pengembangan adalah metode penelitian yang digunakan untuk menghasilkan produk tertentu, dan menguji keefektifan produk tersebut. Penelitian dan pengembangan ini bertujuan mengembangkan alat peraga fisika berbasis konstruktivisme untuk membangun keterampilan generik sains peserta didik pada materi fluida statis. Sasaran penelitian ini adalah seluruh peserta didik kelas XI ilmu pengetahuan Alam di SMA Negeri 1 Sanggar untuk tahun pelajaran 2022/2023. Subjek penelitian yang dipilih adalah Peserta didik kelas 3A semester Ganjil yang sedang mempelajari materi fluida statis. Subjek Penelitian adalah satu kelas dari dua kelas di SMA Negeri 1 Sanggar. Hasil validasi pengembangan alat peraga fisika untuk membangun Keterampilan Generik Sains berbasis konstruktivisme peserta didik SMA pada materi fluida statis menunjukkan skor rata-rata 0,75 dengan persentase 22,43% untuk kriteria sangat baik, skor rata-rata 2,75 dengan persentase persentase 78,57% untuk kriteria baik, sedangkan kategori cukup, kurang, dan sangat tidak baik masing-masing dengan skor rata-rata 0 dengan persentase 0,00%, hal ini menunjukkan bahwa aspek alat peraga dinilai baik oleh validator. Berdasarkan Hasil dari Penelitian Pengembangan alat peraga fisika berbasis konstruktivisme pada materi fluida statis bisa disimpulkan bahwa alat peraga ini dapat membangun Keterampilan Generik Sains peserta didik.
Co-Authors Ardiansyah Ardiansyah Ardiansyah Purnamansyah Purnamansyah