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All Journal Muhammadiyah Journal of Geriatric Neurona
Murni Sri Hastuti
Departemen Neurologi, Fakultas Kedokteran Dan Kesehatan, Universitas Muhammadiyah Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Mixed Dementia: Tinjauan Diagnosis dan Tatalaksana Wiwit Ida Chahyani; Murni Sri Hastuti
Muhammadiyah Journal of Geriatric Vol 1, No 2 (2020): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (629.999 KB) | DOI: 10.24853/mujg.1.2.46-51

Abstract

Latar Belakang: Prevalensi demensia saat ini semakin meningkat, mengenai usia diatas 65 tahun dan risikonya meningkat 2 kali setiap penambahan usia 5 tahun. Salah satu bentuk demensia adalah mixed dementia. Diagnosis mixed dementia sangat sulit dan memberikan tantangan tersendiri bagi para klinisi. Pada artikel ini, penulis ingin membahas mengenai tinjauan diagnosis dan tatalaksana mixed dementia. Hasil: Diagnosis mixed dementia dapat menggunakan beberapa kriteria yaitu International Classification of Diseases and Health Related Problems 10th Revision (ICD-10), the Alzheimer’s Disease Diagnostic and Treatment Centers (ADDTC), dan the National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et l’Enseignement en Neurosciences (NINDS-AIREN). Tatalaksana mixed dementia berupa terapi farmakologi untuk gejala gangguan kognitif dengan pemberian golongan inhibitor kolinesterase dan antagonis NMDA. Terapi farmakologi untuk gangguan psikis dan perilaku dengan antipsikotik atau antidepresan. Managemen faktor risiko hipertensi, konsumsi nutrisi yang sehat, dan olah raga teratur sebagai upaya preventif dan mencegah progresivitas mixed dementia. Kesimpulan: Diagnosis mixed dementia meliputi gejala demensia Alzheimer dan demensia pada penyakit serebrovaskuler. Tatalaksana mixed dementia meliputi terapi gangguan kognitif, psikis, dan perilaku, serta tatalaksana faktor risiko penyakit serebrovaskuler. Dibutuhkan penelitian lebih lanjut serta adanya konsensus diagnosis dan tatalaksana mixed dementia baik nasional maupun internasional agar tercapai tatalaksana secara komprehensif.
LUARAN PASIEN STROKE ISKEMIK AKUT DENGAN INFEKSI COVID-19 DI JAKARTA Wiwit Ida Chahyani; Murni Sri Hastuti; Malika Malika; Izati Rahmi; Maria Regina Rachmawati; Anwar Wardy Warongan (alm); Siti Airiza Ahmad
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.326

Abstract

ABSTRACT Introduction: Ischemic stroke is a life-threatening neurological complication of coronavirus disease 19 (COVID-19). Research on the outcome of acute ischemic stroke patients with COVID-19 infection in Indonesia has not been widely reported. Aims: We investigated the outcome of acute ischemic stroke patients with COVID-19 infection and the factors that affect these outcomes at the Pasar Minggu Regional General Hospital, which is a special COVID-19 referral hospital in Jakarta, Indonesia. Methods: This was a cross sectional study based on the medical records of acute ischemic stroke patients with laboratory-confirmed COVID-19 infection of those ≥18 years of age, who were hospitalized at the Pasar Minggu Regional General Hospital between March 2020 and June 2021. Chi-squared test and unpaired t-test were used for statistical analyses. Results: Thirty-six patients were included in the study. The majority were ≥50 years old (69.4%), comprising of 58.3% women, and 52.8% revealed National Institute of Health Stroke Scale (NIHSS) score of ≤5. The mortality rate of acute ischemic stroke patients with COVID-19 infection was 16.7%, and in the survivors, the median modified Rankin scale score at discharge was 2(1–5). There was a significant association between the severity of COVID-19 and mortality in acute ischemic stroke patients infected with COVID-19 (P=0.019; Odds ratio 1.5 [95% confidence interval 1.08-2.08]). Discussion: The mortality of acute ischemic stroke patients with COVID-19 infection was high, and the factor of significant influence was COVID-19 disease severity. The majority of acute ischemic stroke patients with COVID-19 who survived had mild disabilities.Keywords: COVID-19, ischemic stroke, outcome.
Co-Authors Anwar Wardy Warongan (alm) Izati Rahmi Malika Malika Maria Regina Rachmawati Siti Airiza Ahmad Wiwit Ida Chahyani Wiwit Ida Chahyani