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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Kedokteran Meditek
Freddy Ciptono
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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THE DIFFERENCES OF SODIUM, POTASSIUM AND CHLORIDE LEVELS IN STEMI AND NSTEMI PATIENTS Freddy Ciptono; Muji Rahayu
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1163

Abstract

Infark miokard telah menjadi salah satu penyebab terbesar kematian di seluruh dunia yaitu sebesar 30% dari angka kematiansecara global. STEMI dan NSTEMI dibedakan berdasarkan derajad iskemia yang dialami berupa elevasi segmen ST di pemeriksaan EKGdi pasien STEMI. Peningkatan kadar enzim jantung juga ditemukan baik pada STEMI maupun NSTEMI. Beberapa penelitian terdahulumengungkapkan adanya perubahan kadar elektrolit di pasien infark miokard. Penelitian ini bertujuan untuk menganalisis perbedaankadar natrium, kalium dan klorida di pasien STEMI dan NSTEMI. Penelitian potong lintang, subjek pasien STEMI dan NSTEMI yangdirawat di RSUP Dr. Kariadi, Semarang keluhan angina yang khas, pemeriksaan EKG dengan atau tanpa elevasi segmen ST, disertaidengan peningkatan kadar enzim jantung melebihi batas diagnostik. Data natrium dan klorida dianalisa menggunakan student’s t-testdan data kalium dianalisa menggunakan Mann Whitney U Test. Perbedaan bermakna apabila p< 0,05. Penelitian ini dilakukan di 60subjek dengan rerata umur 53,9 tahun pada kelompok STEMI dan 58,47 pada kelompok NSTEMI. Terdapat perbedaan bermakna padakadar natrium antara pasien STEMI dan NSTEMI (p=0,00). Kadar kalium (p=0,625) dan klorida (p=0,423) tidak memiliki perbedaanbermakna antara dua kelompok tersebut. Terdapat perbedaan yang bermakna antara kadar natrium di pasien STEMI dengan NSTEMI(p< 0,05). Kadar natrium yang didapatkan lebih rendah di pasien STEMI dapat menjadi salah satu petanda laboratorium dalammelakukan diagnosis banding antara STEMI dengan NSTEMI.
Analisis Neutrophil-to-Lymphocyte Ratio dan Platelet-to-Lymphocyte Ratio pada Pasien Infark Miokard Akut Geoffrey Christian Lo; Freddy Ciptono
Jurnal Kedokteran Meditek Vol 31 No 3 (2025): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i3.3563

Abstract

Introduction: Acute myocardial infarction (AMI) is a clinical manifestation of coronary atherosclerosis involving chronic inflammation. Neutrophilia, lymphopenia, and thrombocytosis due to systemic inflammation can be measured using hematological markers neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Previous studies have reported using NLR and PLR to determine the prognosis of cardiovascular disease. Purpose: This study aims to investigate whether NLR and PLR differ in the incidence of AMI, both NSTEMI (non-ST elevation myocardial infarction) and STEMI (ST elevation myocardial infarction), and to evaluate their predictive value. Methods: A cross-sectional study was conducted using complete blood count data from 141 AMI patients treated at Tzu Chi  Hospital from 2018 to 2024 upon their arrival at the emergency room. The data were analyzed using SPSS, utilizing the Mann-Whitney test to identify significant differences, and Receiver Operating Characteristic analysis to assess the predictive value and cut-off points for NLR and PLR. Results: There was a statistically significant difference in NLR in the incidence of AMI (p = 0.013) but no statistically significant difference in PLR in the incidence of AMI (p = 0.549). NLR with a cut-off of 4.34 (sensitivity 60.6%, specificity 60%) showed a low predictive value (AUC = 0.622), and PLR with a cut-off of 158.90 (sensitivity 53%, specificity 57.3%) had no predictive value (AUC = 0.529) to distinguish between NSTEMI and STEMI events. Conclusion: The difference in NLR was more significant and had better predictive value than PLR in AMI
Co-Authors Geoffrey Christian Lo Muji Rahayu