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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Kedokteran Meditek Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Freddy Ciptono
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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THE DIFFERENCES OF SODIUM, POTASSIUM AND CHLORIDE LEVELS IN STEMI AND NSTEMI PATIENTS Freddy Ciptono; Muji Rahayu
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1163

Abstract

Infark miokard telah menjadi salah satu penyebab terbesar kematian di seluruh dunia yaitu sebesar 30% dari angka kematiansecara global. STEMI dan NSTEMI dibedakan berdasarkan derajad iskemia yang dialami berupa elevasi segmen ST di pemeriksaan EKGdi pasien STEMI. Peningkatan kadar enzim jantung juga ditemukan baik pada STEMI maupun NSTEMI. Beberapa penelitian terdahulumengungkapkan adanya perubahan kadar elektrolit di pasien infark miokard. Penelitian ini bertujuan untuk menganalisis perbedaankadar natrium, kalium dan klorida di pasien STEMI dan NSTEMI. Penelitian potong lintang, subjek pasien STEMI dan NSTEMI yangdirawat di RSUP Dr. Kariadi, Semarang keluhan angina yang khas, pemeriksaan EKG dengan atau tanpa elevasi segmen ST, disertaidengan peningkatan kadar enzim jantung melebihi batas diagnostik. Data natrium dan klorida dianalisa menggunakan student’s t-testdan data kalium dianalisa menggunakan Mann Whitney U Test. Perbedaan bermakna apabila p< 0,05. Penelitian ini dilakukan di 60subjek dengan rerata umur 53,9 tahun pada kelompok STEMI dan 58,47 pada kelompok NSTEMI. Terdapat perbedaan bermakna padakadar natrium antara pasien STEMI dan NSTEMI (p=0,00). Kadar kalium (p=0,625) dan klorida (p=0,423) tidak memiliki perbedaanbermakna antara dua kelompok tersebut. Terdapat perbedaan yang bermakna antara kadar natrium di pasien STEMI dengan NSTEMI(p< 0,05). Kadar natrium yang didapatkan lebih rendah di pasien STEMI dapat menjadi salah satu petanda laboratorium dalammelakukan diagnosis banding antara STEMI dengan NSTEMI.
Analisis Neutrophil-to-Lymphocyte Ratio dan Platelet-to-Lymphocyte Ratio pada Pasien Infark Miokard Akut Geoffrey Christian Lo; Freddy Ciptono
Jurnal Kedokteran Meditek Vol 31 No 3 (2025): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i3.3563

Abstract

Introduction: Acute myocardial infarction (AMI) is a clinical manifestation of coronary atherosclerosis involving chronic inflammation. Neutrophilia, lymphopenia, and thrombocytosis due to systemic inflammation can be measured using hematological markers neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Previous studies have reported using NLR and PLR to determine the prognosis of cardiovascular disease. Purpose: This study aims to investigate whether NLR and PLR differ in the incidence of AMI, both NSTEMI (non-ST elevation myocardial infarction) and STEMI (ST elevation myocardial infarction), and to evaluate their predictive value. Methods: A cross-sectional study was conducted using complete blood count data from 141 AMI patients treated at Tzu Chi  Hospital from 2018 to 2024 upon their arrival at the emergency room. The data were analyzed using SPSS, utilizing the Mann-Whitney test to identify significant differences, and Receiver Operating Characteristic analysis to assess the predictive value and cut-off points for NLR and PLR. Results: There was a statistically significant difference in NLR in the incidence of AMI (p = 0.013) but no statistically significant difference in PLR in the incidence of AMI (p = 0.549). NLR with a cut-off of 4.34 (sensitivity 60.6%, specificity 60%) showed a low predictive value (AUC = 0.622), and PLR with a cut-off of 158.90 (sensitivity 53%, specificity 57.3%) had no predictive value (AUC = 0.529) to distinguish between NSTEMI and STEMI events. Conclusion: The difference in NLR was more significant and had better predictive value than PLR in AMI
Korelasi Trombosit dan Hematokrit Sebagai Indikator Klinis Awal pada Pasien Demam Berdarah Dengue di Rumah Sakit Metro Cikarang Utara Tiffany Valerie Alexandra; Freddy Ciptono
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 1 (2026): Maret : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i1.9526

Abstract

Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by a virus, characterized by decreased platelet levels and increased hematocrit levels due to plasma leakage. The assessment of these two parameters is crucial in evaluating the clinical status and severity of the disease. This study aims to analyze the relationship between platelet count and hematocrit levels in patients with Dengue Hemorrhagic Fever (DHF) treated at Metro Cikarang Utara Hospital. An analytical quantitative approach with a cross-sectional design was used, involving data from 124 DHF patients. The analysis revealed that all patients experienced thrombocytopenia, with an average platelet count of 91,430/μL, while hematocrit levels varied, with an average of 42.56%. Spearman correlation test was employed, showing a significant negative correlation between platelet count and hematocrit levels (r = -0.268; p = 0.003). These findings indicate that the lower the platelet count, the higher the potential for increased hematocrit levels. This supports the correlation between thrombocytopenia and hemoconcentration due to plasma leakage, which is a hallmark of the critical phase of DHF. The results emphasize the importance of regular monitoring of these parameters for early detection of clinical deterioration and determination of appropriate clinical interventions.
Co-Authors Geoffrey Christian Lo Muji Rahayu Tiffany Valerie Alexandra