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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Vinisia Setiadji
Clinical Pathology Department, Medical faculty, Universitas Sumatera Utara / Haj Adam Malik Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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THE HEMOGLOBIN, RDW, AND MEAN CORPUSCULAR VALUES IN PATIENTS WITH BETA-THALASSEMIA/HEMOGLOBIN E DISEASE AND BETA-THALASSEMIA TRAIT Vinisia Setiadji; Bidasari Lubis; Adi Koesoema Aman; Herman Hariman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1459

Abstract

Thalassemia beta / hemoglobin E adalah suatu kondisi dengan heterozigot ganda gen pembawa thalassemia beta dan hemoglobin E. Hal ini menyebabkan kondisi dengan gambaran fenotip yang berat dibandingkan trait thalassemia beta dan trait hemoglobin E. Secara logika, nilai mean corpuscular dari thalassemia beta / hemoglobin E seharusnya memburuk. Pada penelitian ini, kami meneliti sebelas kasus dari dua keluarga dengan anggota menderita thalassemia beta / hemoglobin E.Pada keluarga-1 dua anggota dengan trait thalassemia beta memiliki nilai MCV 68 fL dan 65 fL, dan nilai MCH 21 pg dan 20 pg. Pada keluarga-2 anggota dengan trait thalassemia beta memiliki nilai MCV 60,2 fL dan MCH 18,8 pg. Anak perempuan dari kedua keluarga dengan thalassemia beta / hemoglobin E memiliki nilai mean ± SD MCV 70,8 ± 4,9 fL dan MCH 22.8 ± 2.3 pg, nilai ini signifikan lebih tinggi daripada trait thalassemia beta (p<0.05). Terdapat perbedaan yang signifikan antara nilai hemoglobin dan RDW antara thalassemia beta / hemoglobin E (p=0.001).Kami juga menemukan bahwa nilai MC dari keadaan post-transfusi signifikan lebih tinggi daripada pre-transfusi (p<0.001)Kami menyimpulkan bahwa nilai MC dari thalassemia beta / hemoglobin E secara persisten lebih tinggi daripada trait thalassemia beta. Peran transfusi darah pada pasien dengan thalassemia beta / hemoglobin E tampak memainkan peran dalam diskrepansi pada kasus ini.
THE HEMOGLOBIN, RDW, AND MEAN CORPUSCULAR VALUES IN PATIENTS WITH BETA-THALASSEMIA/HEMOGLOBIN E DISEASE AND BETA-THALASSEMIA TRAIT Vinisia Setiadji; Bidasari Lubis; Adi Koesoema Aman; Herman Hariman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1459

Abstract

Beta-thalassemia/hemoglobin E disease is a condition where there is double heterozygosity of beta-thalassemia trait and hemoglobin E trait. This produces a condition with more severe phenotypic appearance compared to beta thalassemia trait and hemoglobin E trait. Logically the Mean Corpuscular Values (MCV) of beta-thalassemia/hemoglobin E disease should also be worsened. The aim of this study was to assess the hemoglobin level, RDW, and MCV between beta-thalassemia/hemoglobin E disease and beta thalassemia trait. The researchers hereby studied eleven cases from two families who were detected to have beta-thalassemia/hemoglobin E disease. Family-1 with beta-thalassemia trait had MCV 68 fL and 65 fL, the MCH value was 21 pg and 20 pg, respectively. In Family-2, mother with beta-thalassemia trait, had MCV 60.2 fL and MCH 18. 8 pg. Daughters with beta-thalassemia/hemoglobin E disease from subjects 1 and 2 whose blood were taken repetitively during visits to the hematology clinic, had mean±SD of MCV 70.8±4.9 fL and Mean Corpuscular Hemoglobin (MCH) value 22.8±2.3 pg. They were significantly higher than the ones with beta-thalassemia trait (p<0.05). Moreover, there were found that the MCV from post-transfusion state were significantly higher than the pre-transfusion state (p<0.001). Based on the study, it could concluded that the MCV from subjects with beta-thalassemia/hemoglobin E disease were persistently higher than the beta-thalassemia trait. The role of blood transfusion in patients with beta-thalassemia/hemoglobin E disease seems to play a part in the result of a discrepancy in this matter.
Co-Authors Adi Koesoema Aman Bidasari Lubis Herman Hariman