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PERALIHAN (KONVERSI) SPUTUM BTA ANTARA PEMBERIAN DOSIS BAKU (STANDAR) DAN TINGGI RIFAMPICIN PADA PENGOBATAN (TERAPI) ANTI TUBERKULOSIS KELOMPOK (KATEGORI) I Yani Triyani; Ida Parwati; I. Sjahid; J. E. Gunawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.917

Acid fast bacilli (AFB) sputum microscopy is used as a diagnostic tool of pulmonary tuberculosis (TB) in TB eradication program with directly observed treatment short course (DOTS) strategy. The AFB sputum microscopy should be performed before treatment,two months after intensive phase and four months after advance phase treatment. This study is a part of a research to compare thestandard (450 mg) and high (600 mg) rifampicin dose in patients with pulmonary tuberculosis in Indonesia. The aim of this studywas to detect the sputum conversion time of AFB in pulmonary TB patients who obtained category I antituberculous treatment with standard dose compared to one who received high dose of rifampicin at the beginning and at the end of the intensive phase. This AFB sputum microscopy have been performed from September 2003 until August 2005 from 85 pulmonary TB patients every two weeksusing Ziehl Neelsen and read by means of International Union Against Tuberculosis and Lung Diseases (IUATLD) scale, in PoliklinikParu Balai Pengobatan Penyakit Paru-paru and Department of Internal Medicine RS. Dr. Hasan Sadikin. Patients with pulmonary TBwho obtained category I antituberculous treatment of the intensive phase were divided randomly double blind into two groups, usingstatistical analysis by Page test for order alternative and Mann Whitney test. After randomization, there were 52 patients who receivedstandard dose and 33 patients who had high dose of rifampicin. Sputum conversions of AFB on week 2, 4, 6, and 8 were 36.1%, 63.9%,75%, and 91.7% for standard dose group. Sputum conversions of AFB on week 2, 4, 6, and 8 were 46.2%, 80.8%, 80.8%, and 84.6%for high dose group. Sputum conversion of AFB for high dose group were faster than standard dose group (p=0.030). Dropout (DO)patients were 5.9% (5/85) and no sputum conversion of AFB on week 8 was 8.3% and 15.4% for standard dose group and high dosegroup of rifampicin, respectively. Sputum conversions of AFB for high dose group were found significant more quickly than standarddose group of rifampicin statistically.

RANCANGAN PRIMER SPESIFIK GEN MACROPHAGE MANNOSE RECEPTOR (MMR) UNTUK POLYMERASE CHAIN REACTION (PCR) DAN SEKUENSING DEOXYRIBO NUCLEIC ACID (DNA) Yani Triyani; Nurizzatun Nafsi; Lelly Yuniarti; Nanan Sekarwana; Endang Sutedja; Dida Ahmad Gurnida; Ida Parwati; Bachti Alisjahbana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1120

The order (sequencing) determinationof DeoxyribonucleicAcid (DNA) bases is the gene’s most basic information, using the methodof Polymerase Chain Reaction (PCR) as its stage. A key factor of successful detection by PCR is specific PCR primer design choice. Thedetection of diversity of Mycobacterium Mannose Receptor (MMR) gene, responsible for recognizing mannosylated antigen structureof Mycobacterium tuberculosis (M.tb) by DNA sequencing of exon 7 chromosome 10p12, related to susceptiblity for PulmonaryTuberculosis(TB), was first performed in China in 2012. The purpose of this study was to find specific primerfromboth design originatedfrom the research in China/primer I and my own design/primer IIby using Primer3 software. This study was based on 10 healthy subjectsand was a preliminary study of a research titled. The Relationship of Single Nucleotide Polymorphisms (SNPs) of Macrophage MannoseReceptor Gene to Pulmonary Tuberculosis Cases. The examination materials consist of 3 mL of EDTA blood and DNA extraction from itsbuffy coat. The resulting DNA was processed by PCR to amplify MMR gene with primer I and II. The primer I successfully amplified DNAfragments up to 780bp while primer II only 329 bp. The MMR gene DNA sequencing analysis was performed on the amplification resultof both kinds primers by using DNA Baser and Ensembl−BLAST software. The results were different, DNA sequencing result by using theprimer I was found in several chromosomes and also in several loci. Whereas, by using the primer II, it was only found in chromosome10 and in the same locus. Based on this study, it can be concluded that the specific primer design is one of the most important factorsin the success of DNA sequencing.

Peran Parameter Trombosit sebagai Biomarker Keparahan dan Prognosis Pasien Coronavirus Disease 2019 Nadya Aulia Rahmadhanty; Yani Triyani
Jurnal Riset Kedokteran Volume 2, No.1, Juli 2022, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Abstract. Increased risk of mortality of Coronavirus Disease 2019 (COVID-19) patients with severe symptoms, often associated with cytokine storms. Cytokine storms can cause damage to bone marrow progenitor cells so that reduced platelet production leads to thrombocytopenia. Monitoring platelet parameters as a laboratory test that is easily available, affordable, and widely used, can also be used to monitor cytokine storms of COVID-19 patients. The aim of this study was to determine the role of platelet parameters as potential indicators of assessing the clinical degree of COVID-19 patients. The method of this study was scoping review. The databases used were PubMed, SpringerLink, and ScienceDirect with a total of 788 search results. The screening result of articles that suit the inclusion criteria were 162 articles and those that suit the eligibility criteria are reviewed as many as 6 articles. The results of the analysis of 6 articles reviewed, 5 articles showed that platelet count can assess the severity and prognosis in COVID-19 patients and 1 article shows that the Mean Platelet Volume value does not act as a good predictor for the severity of COVID-19 disease. The conclusion of this study is that platelet parameters act as biomarkers of the severity and prognosis of COVID-19 patients. Platelet count is more effective as a biomarker of the severity and prognosis of COVID-19 patients compared to Mean Platelet Volume, Plateletcrit, Platelet Distribution Width, and Platelet Large Cell Ratio. Abstrak. Peningkatan risiko mortalitas pasien Coronavirus Disease 2019 (COVID-19) dengan gejala parah, sering dikaitkan dengan adanya badai sitokin. Badai sitokin dapat menyebabkan kerusakan sel progenitor bone marrow sehingga produksi trombosit berkurang menyebabkan trombositopenia. Pemantauan parameter trombosit sebagai tes laboratorium yang mudah tersedia, terjangkau, dan banyak digunakan, dapat juga dilakukan untuk memantau badai sitokin pasien COVID-19. Tujuan penelitian ini untuk mengetahui peran parameter trombosit sebagai indikator potensial menilai derajat klinis pasien COVID-19. Penelitian ini menggunakan metode scoping review. Database yang digunakan yaitu PubMed, SpringerLink, dan ScienceDirect dengan jumlah artikel hasil pencarian sebanyak 788. Jumlah artikel yang sesuai dengan kriteria inklusi sebanyak 162 dan yang memenuhi kriteria eligibility direview sebanyak 6 artikel. Hasil analisis 6 artikel yang di-review, 5 artikel menunjukkan bahwa hitung jumlah trombosit dapat menilai tingkat keparahan dan prognosis pada pasien COVID-19 serta 1 artikel menunjukkan bahwa nilai Mean Platelet Volume tidak berperan sebagai prediktor yang baik untuk tingkat keparahan penyakit COVID-19. Kesimpulan penelitian ini adalah parameter trombosit berperan sebagai biomarker keparahan dan prognosis pasien COVID-19. Hitung jumlah trombosit lebih efektif berperan sebagai biomarker keparahan dan prognosis pasien COVID-19 dibanding dengan Mean Platelet Volume, Plateletcrit, Platelet Distribution Width, dan Platelet Large Cell Ratio.

Hubungan Usia dan Lingkungan Pasien Tuberkulosis Paru Berdasarkan Hasil Positif dan Negatif Tes Cepat Molekular di RS Al-Islam Bandung Tahun 2018-2019 Nadya Safira; Yani Triyani; Dadang Rukanta
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.167

Abstract. The infectious disease with the highest mortality caused by the bacterium Mycobacterium tuberculosis is Tuberculosis (TB). There are several risk factors that can cause a person to get TB including the environment in which they live, age, and gender. The purpose of this study was to corelation the age and address of TB patients with positive and negative results of the rapid molecular diagnostics (RMD) at AL-Islam Hospital, Bandung. This research was conducted by analytical observation with a cross-sectional approach. The sampling technique used was purposive sampling from medical record data for 2018-2019 with the number of samples that entered the inclusion criteria as many as 253 people. Data analysis using Chi-square test. The results showed that there were 122 positive pulmonary TB patients (48.2%) and 131 negative patients (51.8%). Based on the positive age, the productive age was 99 people (39.1%) and based on the positive environment was the dense environment as many as 117 people (46.2%). The results of the bivariate statistical test showed that there was a relationship between productive age and the incidence of TB because many of these ages did things outside, but with the environment there was no relationship because apart from density there was another risk factor, namely humidity. Abstrak. Penyakit infeksi yang menular dengan kematian paling tinggi yang disebabkan bakteri Mycobacterium tuberculosis adalah penyakit Tuberkulosis (TB). Terdapat beberapa faktor risiko yang bisa menyebabkan seseorang terkena TB diantaranya adalah lingkungan tempat tinggal, usia, dan jenis kelamin. Tujuan penelitian ini adalah menghubungkan bagaimana usia, dan alamat pasien TB dengan hasil positif dan negatif Tes Cepat Molekular (TCM) di RS AL-Islam Bandung. Penelitian ini dilakukan secara observasional analitik dengan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan Purposive Sampling dari data rekam medis tahun 2018-2019 dengan jumlah sampel yang masuk dalam kriteria inklusi sebanyak 253 orang. Analisis data menggunakan uji Chi-square. Hasil penelitian didapatkan bahwa pasien TB Paru yang positif 122 orang (48,2%) dan negatif 131 orang (51,8%). Berdasarkan usia yang lebih banyak yang positif adalah usia produktif sebanyak 99 orang (39,1%) dan berdasarkan lingkungan yang positif adalah lingkungan padat sebanyak 117 orang (46,2%). Hasil uji statistic bivariat menunjukkan terdapat hubungan antara usia produktif dengan kejadian TB dikarenakan banyak usia tersebut melakukan hal diluar, namun dengan lingkungan tidak terdapat hubungan dikarenakan selain kepadatan terdapat faktor risiko lain yaitu kelembapan.

Gambaran Usia dan Jenis Kelamin Pasien Tuberkulosis Rifampisin Sensitif Berdasar Atas Tes Cepat Molekuler di RS Al-Islam Kota Bandung Tahun 2018−2019 Elfira Azmi Nabilah; Yani Triyani; Siti Annisa Devi Trusda
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.429

Abstract. Tuberculosis (TB) is an infectious disease that is still a major cause of health problems and one of the top ten causes of global mortality. The World Health Organization (WHO) has recommended the diagnosis of tuberculosis patients using the Rapid Molecular Test (Xpert MTB/RIF test), which detect the rifampin resistance (rpoB) gene encoding M. tuberculosis in sputum in approximately two hours and can help diagnose new patients TB can be quickly detected. The objective of this study was to determine the characteristics of rifampin-sensitive. This is was a descriptive study with a cross sectional approach, describing the characteristics of rifampin-sensitive and resistant TB patients based on age and sex. Data in the form of medical records were taken from the clinical pathology lab section of the Al Islam Hospital, Bandung City in 2018–2019. Data collection was carried out in July-August 2021. Total research subjects were 265 people who met the inclusion criteria. The results showed that TB patients with positive rifampin-sensitive Xpert MTB/RIF test had the characteristics of the early adolescent to the ederly age group, the most frequent was adult age group as many as 92 people (34.7%), while female (51.7%) was higher than male. The conclusion of this study that the characteristics of sensitive rifampin TB patients based on Xpert MTB/RIF test at Al Islam Hospital in Bandung City in 2018–2019 were mostly found to be adults and female. Abstrak. Tuberkulosis (TB) merupakan salah satu penyakit menular yang dapat menjadi penyebab utama dalam gangguan kesehatan dan salah satu dari sepuluh penyebab kematian utama di seluruh dunia. World Health Organization (WHO) telah merekomendasikan diagnosis pasien tuberkulosis menggunakan Tes Cepat Molekuler (TCM) dengan Xpert MTB/RIF, alat ini dapat mendeteksi gen pengkode resisten rifampisin (rpoB) M.tuberculosis pada sputum kurang lebih dua jam serta dapat membantu penegakan diagnostik pasien TB yang baru bisa dengan cepat terdeteksi. Tujuan penelitian ini melihat karakteristik usia dan jenis kelamin pasien TB rifampisin sensitif. Rancangan penelitian ini adalah deskriptif dengan pendekatan cross sectional yang menggambarkan karakteristik pasien TB rifampisin sensitif berdasar atas usia dan jenis kelamin. Data berupa rekam medis diambil dari bagian Lab Patologi Klinik Rumah Sakit Al Islam Kota Bandung periode 2018–2019. Pengambilan data dilakukan pada Juli−Agustus 2021. Total subjek penelitian 265 orang yang memenuhi kriteria inklusi. Hasil penelitian menunjukan pasien TB dengan hasil TCM positif rifampisin sensitif memiliki karakteristik kelompok usia remaja awal hingga manula, kelompok usia terbanyak adalah dewasa (26−45 tahun) sebanyak 92 orang (34,7%). Jumlah pasien laki-laki dan perempuan hampir sama, tetapi lebih banyak pasien berjenis kelamin perempuan yaitu sebanyak (51,7%). Kesimpulan dari penelitian ini bahwa pasien TB rifampisin sensitif berdasar atas hasil TCM di RS-Al Islam Kota Bandung tahun 2018–2019 paling banyak ditemukan kelompok usia dewasa, berjenis kelamin perempuan.

Scoping Review: Efektivitas Chest X-Ray Brixia Score untuk Menilai Derajat Keparahan COVID-19 Natassja Salsabilla; Yani Triyani; Dyana Eka Hadiati
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.922

Abstract. The use of chest x-rays in Covid-19 pandemic has become an alternative radiological examination that is extensively carried out, although it is less sensitive, but is widely available and its use is mobile to detect lung abnormalities in Covid-19 patients using the brixia score assessment. The purpose of this study was to determine the effectiveness of chest x-rays using the brixia score to assess the severity of Covid-19. This research was taken by scoping review method with a sample of international scientific articles that meet the eligibility criteria. The databases used in this study are Spingerlink, Sciencedirect, Pubmed, Google scholar, and Proquest with the number of articles obtained as many as 833 articles. The results of the screening of articles that met the inclusion criteria were 275 articles and there were three articles that met the eligibility criteria. The results of the three reviewed articles, one article compared the use of chest x-ray and CT in detecting lesions of Covid-19 patients with the result that chest x-ray had low sensitivity. Two articles compared the brixia score in patients who died and discharged with higher outcomes in patients who died. The conclusion of this study shows that the use of chest x-rays is not effective for detecting early-stage abnormalities and the brixia score is effective for assessing the severity of Covid-19 patients. Abstrak. Penggunaan Chest x-ray di era pandemi Covid-19 menjadi pemeriksaan radiologis alternatif yang banyak dilakukan walaupun kurang sensitif, tetapi tersedia luas dan penggunaannya mobile untuk mendeteksi kelainan paru pada pasien Covid-19 menggunakan penilaian brixia score. Tujuan penelitian ini adalah untuk mengetahui efektivitas chest x-ray menggunakan penilaian brixia score untuk menilai keparahan Covid-19. Penelitian ini diambil dengan metode scoping review dengan sampel artikel ilmiah internasional yang memenuhi kriteria kelayakan (eligible). Database yang digunakan pada penelitian ini adalah Spingerlink, Sciencedirect, Pubmed, Google scholar, dan Proquest dengan jumlah artikel yang didapatkan sebanyak 833 artikel. Hasil skrining artikel yang sesuai dengan kriteria inklusi sebanyak 275 artikel dan artikel yang memenuhi kelayakan terdapat tiga artikel. Hasil dari tiga artikel yang telah di-review, satu artikel membandingkan penggunaan chest x-ray dan CT dalam mendeteksi lesi pasien Covid-19 dengan hasil adalah pemeriksaan chest x-ray mempunyai sensitivitas yang rendah. Dua artikel membandingkan nilai brixia score pada pasien meninggal dan dipulangkan dengan hasil lebih tinggi pada pasien meninggal yaitu 12 poin. Kesimpulan penelitian ini menunjukkan penggunan chest x-ray tidak efektif untuk mendeteksi kelainan tahap awal dan brixia score efektif untuk menilai derajat keparahan pasien Covid-19.

Scoping Review: Hubungan Index Keparahan Gambaran Chest X-Ray dengan Usia pada Pasien Terkonfirmasi COVID-19 Naya Valenski; Yani Triyani; Dede Setiapriagung
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1351

Abstract. One of the impacts of COVID-19 infection is the manifestation in the lungs due to the COVID-19 virus attacks the respiratory tract. Therefore, radiographic examination is needed for monitoring the severity of the lungs of patients with confirmed COVID-19. The severity of the Chest X-Ray can be calculated using an assessment score such as Brixia Score. Factors that affect the severity of chest X-Ray include age in patients with confirmed COVID-19. Older age increases the severity of Chest X-Ray because the immune system declines with age. Thus, the aim of this study was to determine the relationship between the severity index of Chest X-Ray with age in patients with confirmed COVID-19. The study was taken using the scoping review method with a sample of international scientific articles that met the eligibility criteria (elegible). The results in this study were taken from three databases, namely Science Direct, Springer Link and Proquest as well as the Google Scholar scientific publication search feature with 795 initial search results and three eligible articles. The results of three articles, one article uses the RALE (Radiographic Assessment of Lung Edema) score with the results that there is a relationship between the severity of Chest X-Ray and the age of patients with confirmed COVID-19, namely the higher the age, the higher the severity of the Chest X-Ray. The other two articles used the Brixia score with similar results using the RALE score. The conclusion of this study shows that there is a relationship between the severity of Chest X-Ray and age in patients with confirmed COVID-19. Abstrak. Salah satu dampak infeksi COVID-19 adanya manifestasi pada organ paru dikarenakan virus COVID-19 menyerang saluran pernapasan. Oleh karena itu, diperlukan pemeriksaan radiografi untuk monitoring keparahan pada paru pasien terkonfirmasi COVID-19. Keparahan pada gambaran Chest X-Ray dapat dihitung dengan menggunakan skor penilaian seperti skor Brixia. Faktor yang mempengaruhi tingkat keparahan gambaran Chest X-Ray antara lain usia pada pasien terkonfirmasi COVID-19. Usia yang lebih tua meningkatkan tingkat keparahan gambaran Chest X-Ray disebabkan oleh sistem imun yang menurun seiring bertambah usia. Tujuan penelitian untuk mengetahui hubungan indeks keparahan gambaran Chest X-Ray dengan usia pada pasien terkonfirmasi COVID-19. Penelitian diambil dengan metode scoping review dengan sampel artikel ilmiah internasional yang memenuhi kriteria kelayakan (elegible). Hasil pada penelitian ini diambil dari tiga database yaitu Science Direct, Springer Link dan Proquest serta fitur pencarian publikasi ilmiah Google Scholar dengan hasil pencarian awal terdapat 795 dan artikel yang memenuhi kelayakan (eligible) ada tiga artikel. Hasil dari tiga artikel, satu artikel menggunakan skor RALE (Radiographic Assesment of Lung Edema) dengan hasil terdapat hubungan antara tingkat keparahan gambaran Chest X-Ray dengan usia pasien terkonfirmasi COVID-19 yaitu semakin tinggi usia maka semakin tinggi tingkat keparahan gambaran Chest X-Ray. Dua artikel lainnya menggunakan skor Brixia dengan hasil yang sama dengan menggunakan skor RALE. Kesimpulan penelitian ini menunjukan bahwa terdapat hubungan antara tingkat keparahan gambaran Chest X-Ray dengan usia pada pasien terkonfirmasi COVID-19.

Peran Rasio Trombosit Limfosit dalam Memprediksi Tingkat Keparahan Pasien Covid-19 Tania; Yani Triyani; Rika Nilapsari
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5963

Abstract. COVID-19 is an infectious disease caused by the SARS-CoV-2 group. This disease has been declared by the WHO as a global pandemic. The first case of COVID-19 in Indonesia was reported on March 2, 2020, and the number has continued to increase until now. COVID-19 in Indonesia has spread to various regions, accompanied by increased cases and deaths. The severity of COVID-19 patients is classified into four, namely mild, moderate, severe, and critical, which can be determined by measuring the platelet-lymphocyte ratio value at routine hematological examinations. This RTL has become a new indicator of inflammation to determine the severity of COVID-19. Based on this phenomenon, the problem in this research is formulated as follows: (1) Is there a relationship between the platelet-lymphocyte ratio in moderate cases of COVID-19 at Al-Islam Hospital in Bandung? (2) Is there a relationship between the platelet-lymphocyte ratio in severe cases of COVID-19 at Al-Islam Hospital in Bandung? (3) Does the platelet-lymphocyte ratio act as an indicator of the severity of COVID-19 patients at Al-Islam Hospital Bandung? (4) What is the cut-off value of the platelet-lymphocyte ratio as an indicator of severity in COVID-19 patients at Al-Islam Hospital in Bandung?. The research design uses a diagnostic test method with a cross-sectional approach with data analysis techniques using Chi-square. The population selected in this study were confirmed COVID-19 patients based on RT-PCR results, which were treated at Bandung Al-Islam Hospital. Using the sampling technique, Total Sampling, the number of research samples was 350 patients. The data collection technique used in this study was from medical records. The data analysis technique used in this research is the descriptive analysis technique. The results of this study are: There is a relationship between the platelet-lymphocyte ratio (p-value=0.009) and the severity of COVID-19 patients at Al-Islam Hospital Bandung. Abstrak. COVID-19 merupakan penyakit menular yang disebabkan oleh kelompok SARS-CoV-2. Penyakit ini telah ditetapkan oleh WHO sebagai pandemi global. Kasus pertama COVID-19 di Indonesia dilaporkan pada tanggal 2 Maret 2020, dan jumlahnya terus meningkat hingga sekarang. Penyebaran COVID-19 di Indonesia menyebar ke berbagai wilayah dengan diiringi peningkatan jumlah kasus dan kematian. Derajat keparahan pasien COVID-19 diklasifikasikan menjadi empat yaitu derajat ringan, sedang, berat dan kritis yang dapat ditentukan dengan mengukur nilai rasio trombosit limfosit pada pemeriksaan hematologi rutin. RTL ini ini telah menjadi salah satu indikator peradangan yang baru untuk menentukan derajat keparahan COVID-19. Berdasarkan hal tersebut, maka permasalahan dalam penelitian ini dirumuskan sebagai berikut: (1) Apakah terdapat hubungan antara rasio trombosit limfosit pada kasus COVID-19 derajat sedang di RS Al-Islam Bandung? (2) Apakah terdapat hubungan antara rasio trombosit limfosit pada kasus COVID-19 derajat berat di RS Al-Islam Bandung? (3) Apakah rasio trombosit limfosit berperan sebagai indikator derajat keparahan pasien COVID-19 di RS Al-Islam Bandung? (4) Berapakah nilai cut off rasio trombosit limfosit sebagai indikator derajat keparahan pada pasien COVID-19 di RS Al-Islam Bandung?. Desain penelitian ini menggunakan metode uji diagnostik dengan pendekatan cross sectional dengan teknik analisis data menggunakan Chi-square. Populasi yang dipilih dalam penelitian ini adalah pasien terkonfirmasi COVID-19 berdasarkan hasil RT-PCR yang di rawat di Rumah Sakit Al-Islam Bandung. Dengan teknik pengambilan sampel yaitu Total Sampling diperoleh jumlah sampel penelitian sebanyak 350 pasien. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah dari rekam medik. Adapun teknik analisis data yang digunakan dalam penelitian ini adalah teknik analisis deskriptif. Hasil penelitian ini adalah: Terdapat hubungan antara rasio trombosit limfosit (p-value=0,009) dengan derajat keparahan pasien COVID-19 di Rumah Sakit Al-Islam Bandung.

Diabetes Melitus sebagai Komorbiditas Utama terhadap Mortalitas Pasien COVID-19 Zahra Salsabila; Yani Triyani; Sadiah Achmad
Jurnal Riset Kedokteran Volume 3, No.2, Desember 2023, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.v3i2.3000

Abstract. The purpose of this study was to analyze the relationship between comorbidities and mortality in COVID-19 patients. This study uses analytic methods with a cross-sectional research design. Data were obtained from the medical records of inpatients with confirmed COVID-19 at Al-Islam Hospital Bandung for the 2021 period. The statistical test used a univariate data test by looking at the characteristics of COVID-19 patients based on age, sex, and length of stay and using the Chi test -Square to analyze whether there is a relationship between the independent and dependent variables. The number of respondents in this study was 2,047 people, with the most age being ≥60 years (39.5%), male sex (51.3%), with the highest comorbidity diabetes mellitus (41.9%), followed by hypertension (35.7%) and renal disease (12.4%) which have CFR values of 10.1%, 5.9%, and 5.2% respectively. Patients with comorbid diseases have a decreased immune response and the location of ACE-2 receptors is found not only in the respiratory tract but also in other organs such as the pancreas and kidneys. The conclusion shows that there is a relationship between comorbidities and mortality of COVID-19 patients at Al-Islam Hospital Bandung in 2021 with a p-value <0.001 (p <0.05). Abstrak. Tujuan penelitian ini adalah menganalisis hubungan komorbiditas dengan mortalitas pasien COVID-19. Penelitian ini menggunakan metode analitik dengan rancangan penelitian cross sectional. Data diperoleh dari rekam medis pasien rawat inap yang terkonfirmasi COVID-19 di Rumah Sakit Al-Islam Bandung Periode 2021. Uji Statistik menggunakan uji data univariat dengan melihat karakteristik pasien COVID-19 berdasarkan usia, jenis kelamin, dan lama rawat inap serta menggunakan uji Chi-Square untuk menganalisis ada tidaknya hubungan antara variable bebas dan terikat. Jumlah responden pada penelitian ini sebanyak 2.047 orang, dengan usia yang paling banyak ≥60 tahun (39,5%), jenis kelamin laki-laki (51,3%), dengan komorbiditas tertinggi diabetes melitus (41,9%), disusul dengan hipertensi (35,7%) dan renal disease (12,4%) yang memiliki nilai CFR berturut-turut 10,1%, 5,9%, dan 5,2%. Pasien dengan penyakit komorbid berada dalam penurunan respon imun serta lokasi reseptor ACE-2 yang ditemukan tidak hanya di saluran respirasi, tetapi juga didapatkan di organ lain seperti pankreas dan ginjal. Kesimpulan menunjukkan terdapat hubungan komorbiditas dengan mortalitas pasien COVID-19 di RS Al-Islam Bandung tahun 2021 dengan nilai p <0.001 (p<0.05).

Tingkat Pengetahuan Talasemia Pada Mahasiswa Fakultas Kedokteran Universitas Islam Bandung Intan Purnamasari; Yani Triyani; Sara Puspita
Jurnal Riset Kedokteran Volume 4, No.1, Juli 2024, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.v4i1.3755

Abstract. Thalassemia is a congenital blood disorder caused by failure to form hemoglobin which damages red blood cells and results in anemia or lack of blood in sufferers. As the number of thalassemia sufferers increases, awareness of the importance of knowledge of thalassemia must be raised among the public, especially among students at the Faculty of Medicine, Bandung Islamic University as medical personnel in the future must be able to educate the public well. This research aims to determine the level of knowledge of students at the Faculty of Medicine, Islamic University of Bandung about thalassemia. The research subjects were 204 people. This research uses an analytical observational method with a cross-sectional approach. The results of this research show that the majority of students at the Faculty of Medicine, Bandung Islamic University for the 2022/2023 academic year have a good level of knowledge regarding thalassemia (85.3%). A good level of knowledge among students, especially students at the Faculty of Medicine, Bandung Islamic University, is influenced by several things. Students can get information from various sources, starting from formal education and information available on social media. The sources of information obtained by students can increase understanding and knowledge regarding the definition, diagnosis, management and prevention of thalassemia. Abstrak. Talasemia adalah kelainan darah bawaan yang disebabkan oleh kegagalan pembentukan hemoglobin yang merusak sel darah merah dan mengakibatkan anemia atau kekurangan darah pada penderita. Seiring bertambahnya jumlah penderita talasemia, kesadaran akan pentingnya pengetahuan talasemia harus ditumbuhkan di kalangan masyarakat khususnya pada mahasiswa Fakultas Kedokteran Universitas Islam Bandung sebagai tenaga medis di masa yang akan datang sehingga harus mampu mengedukasi masyarakat dengan baik. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan mahasiswa Fakultas Kedokteran Universitas Islam Bandung tentang talasemi. Subjek penelitian sebanyak 204 responden. Penelitian ini menggunakan metode observasional analitik dengan pendekatan potong lintang. Hasil penelitian ini menunjukkan bahwa hasil dari penelitian ini menunjukan bahwa sebagian besar Mahasiswa Fakultas Kedokteran Universitas Islam Bandung tahun akademik 2022/2023 memiliki tingkat pengetahuan yang baik mengenai talasemia (85.3%). Tingkat pengetahuan yang baik pada mahasiswa khususnya pada mahasiswa Fakultas kedokteran Universitas Islam Bandung dipengaruhi oleh beberapa hal. Mahasiswa dapat mendapatkan informasi dari berbagai sumber, mulai dari pendidikan formal maupun informasi yang tersedia di media sosial. Sumber informasi yang didapat oleh mahasiswa dapat meningkatkan pemahaman serta pengetahuan terhadapa pengertian, diagnosis, tatalaksana, serta pencegahan talasemia.

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