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FORMULASI TABLET EKSTRAK DAUN SAMBILOTO (Andrographis paniculata N.) SECARA KEMPA LANGSUNG DENGAN KOMBINASI MANITOL – SORBITOL SEBAGAI BAHAN PENGISI Lutfiana Kusumawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (461.771 KB) | DOI: 10.22487/j24428744.2015.v1.i2.6216

Abstract

It has been conducted research about Tablets Formulation of Creat (Andrographis paniculata N.) Leaves Extract in Directly Compressed with Combination of Manitol-Sorbitol as Filler Materials. The result of test shows that every formula fulfills test conditions of quality for uniformity of weight, brittleness, size measure and hardness, such as those which qualified by Farmacope Indonesia and other monographs. Statistical test using Ansira (Variance Design Analysis) indicates that usage of filler materials combinations mannitol – sorbitol for formula I, II and III respectively 50% : 50%, 75% : 25% dan 25% : 75%, yield no significant effect for physical quality tablet
UJI AKTIVITAS ANTIINFLAMASI KOMBINASI DEKOKTA AKAR BELUNTAS (Pluchea indica L.) DAN INFUSA DAUN JAMBU BIJI (Psidium guajava L.) TERHADAP TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI KARAGENAN Ersamukti Rahmatullah Achmad; Yuliet Yuliet; Lutfiana Kusumawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.98 KB) | DOI: 10.22487/j24428744.2015.v1.i2.6243

Abstract

Marsh fleabane roots (Pluchea indica L.) and guava leaves (Psidium guajava L.) are traditionally used as an anti-inflammatory. The research has been conducted with the aim of knowing the anti-inflammatory effect of the combination of decoction of Marsh fleabane  roots (Pluchea indica L.) and infusion of guava leaves (Psidium guajava L.), and also determining  the effective concentration of such combination. The research used artificial edema method in white rat's leg ( Rattus norvegicus) with the observation for 6 hours on the change of leg volume in white rat.  The measurement of white rat's leg volume used a pletismometer. The type of treatment was devided into 5 groups: negative control (Aquadest), positive control (Na Diclofenac), combination 1 (MFR 10% : IGL 8%), combination 2 (MFR 5% : IGL 5%), and combination 3 (MFR 8% : IGL 10%).  The data obtained were processed using One-Way ANOVA method with the result seen on the percent inhibition of inflammation resulting concentration of MFR 5%: IGL 5% amounting to 23.47%, and subsequently combined with a concentration of MFR 10% : IGL 8% and concentrations MFR 8% : IGL 10% respectively by the percent inhibition of inflammation by 20.70% and 13.75%.  The data obtained show the combination with a concentration of 5% : 5% have anti- inflammatory effect are better than the other combinations as well as comparable to the positive  control