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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Henny Elfira Yanti
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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PENYAKIT VIRUS EBOLA Henny Elfira Yanti; Aryati Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1108

Abstract

Ebola virus disease has known as Ebola hemorrhagic fever (EHF) is an acute viral syndrome characterized by fever and bleeding witha high mortality rate in humans and non human (primates). The current outbreak inWestern Africa is the largest ebola outbreak since theebola virus was first discovered in 1976. The first EHF case that reemerged back in Africa occurred in March 2014 and in Desember 29th2014 had been revealed 20,153 cases and 7,883 deaths. The virus is transmitted from wild animals and spread in the human populationthrough human –to -human transmission. Ebola virus infection is characterized by immunosuppression and systemic inflammatoryresponse. Both condition cause the damage of blood vessels, coagulation and disorders of the immune system, leading to multiple organfailure and shock. Until now there are no ebola standards treatment guidelines. However, the life survival increased with early supportivecare such as rehydration and symptomatic treatment.
CORRELATION OF NEUTROPHILS/LYMPHOCTES RATIO AND C-REACTIVE PROTEIN IN SEPSIS PATIENTS Henny Elfira Yanti; Fery H Soedewo; Puspa Wardhani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1143

Abstract

Sepsis merupakan penyebab umum dari kesakitan dan kematian di seluruh dunia. Diagnosis yang cepat dan tepat sangatdiperlukan. Salah satu respons fisiologis pada sistem imunitas terhadap inflamasi sistemik adalah peningkatan jumlah neutrofil danpenurunan jumlah limfosit. Rasio neutrofil/limfosit telah diketahui sebagai petanda inflamasi yang cepat, sederhana dan murah. Tujuanpenelitian ini adalah membuktikan adanya kenasaban antara rasio neutrofil/limfosit dan c-reactive protein di pasien sepsis. Penelitianbersifat ptong lintang observasional, dilakukan masa waktu Januari hingga Juni 2015. Sampel penelitian terdiri dari 42 pasien sepsisyang dirawat di Instalasi Rawat Darurat RSUD Dr. Soetomo Surabaya. Semua sampel dilakukan pemeriksaan jumlah limfosit, neutrofil,CRP. Hasil dianalisis menggunakan uji kenasaban Spearman’s. Rasio neutrofil/limfosit berkisar antara 3,42–57,47 (21,74±14,1). KadarCRP antara 1,22 mg/L–361,86 mg/L (158 mg/L±97,4 mg/L). Hasil penelitian tidak terdapat kenasaban antara RNL dan kadar CRPdi pasien sepsis (p=0,51). Tidak terdapat kenasaban antara RNL dan kadar CRP di pasien sepsis. Hal ini disebabkan adanya perbedaanjalur aktivasi antara neutrofil dengan CRP sehingga menyebabkan peningkatan CRP tidak sebanding dengan peningkatan jumlahneutrofil.
Co-Authors Aryati Aryati Fery H Soedewo Puspa Wardhani Puspa Wardhani