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VALIDASI METODE ANALISIS KADAR AMBROKSOL HIDROKLORIDA DALAM SEDIAAN TABLET CYSTELIS SECARA KROMATOGRAFI CAIR KINERJA TINGGI Ade Heri Mulyati; - Sutanto; Dewi Apriyani
EKOLOGIA Vol 11, No 2 (2011): JURNAL ILMIAH ILMU DASAR DAN LINGKUNGAN HIDUP
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.014 KB) | DOI: 10.33751/ekol.v11i2.259

Abstract

Cystelis tablet is an expectorant medicine which contain 30 mg/tablet of Ambroxol Hydrochloride. To ensure the safety and effectiveness of the medicine must be well controlled especially the analytical methode which used to determined the actived ingredient in the medicine. This analytical methode must resulting the amount of Ambroxol Hydrochloride which can be trusted. The purpose of this research are to test and proof the result of determination Ambroxol Hydrochloride in Cystelis tablet could be trusted in daily test in laboratorium. Analytical methode validation is a effort to get and documented proof that the result of test methode can be trusted with some specification. The Parameters of analytical methode validation are precision, linearity, accuracy, range, selectivity, and stability test (robustness). Analytical methode that used in pharmacy specially High Performance Liquid Chromatography (HPLC), using mobile phase metanol : buffer potassium dyhidrogen phosphate 0,01 M (70:30) pH 6,0 and stationary phase C18 Symmetry (150 mm x 4,6 mm) with particle size 5mm, flow rate 1,0 mL/minute, injection volume 10,0 mL and measured at wavelength 247 nm. Analytical results showed that the placebo did not gived any analytical respons in selectivity test. Accuracy which know as % recovery showed the average of % recovery 99,31% (98,70 100,44%), range between 80%-120%. Linearity at consentration range 70% - 130% with coefficient correlacy (r) 0,99924. The result of precision which is repeatability with average of % RSD 0,25%. Based on t value and F value on intermediate precision showed that there is no differently result gived by the analytical methode with different analyst and time. Stability test solution and mobile phase composition with % bias 2% and %RSD 2%. Based on the analytical methode validation result the determination of Ambroxol Hydrochloride in Cystelis tablet with high performace liquid chromatography we can conclude that this analytical methode is valid to implemented in daily inspection at Quality Control laboratory PT. Armoxindo FarmaKata kunci : Validation, Analytical methode, Ambroxol Hydrochloride, HPLC
VALIDASI METODE ANALISIS KADAR AMBROKSOL HIDROKLORIDA DALAM SEDIAAN TABLET CYSTELIS® SECARA KROMATOGRAFI CAIR KINERJA TINGGI Ade Heri Mulyati; - Sutanto; Dewi Apriyani
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 11, No 2 (2011): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v11i2.259

Abstract

Cystelis® tablet is an expectorant medicine which contain 30 mg/tablet of Ambroxol Hydrochloride. To ensure the safety and effectiveness of the medicine must be well controlled especially the analytical methode which used to determined the actived ingredient in the medicine. This analytical methode must resulting the amount of Ambroxol Hydrochloride which can be trusted. The purpose of this research are to test and proof the result of determination Ambroxol Hydrochloride in Cystelis® tablet could be trusted in daily test in laboratorium. Analytical methode  validation is a effort to get and documented proof that the result of test methode can be trusted with some specification. The Parameters of analytical methode validation are precision,  linearity, accuracy, range, selectivity, and stability test (robustness). Analytical methode that used in pharmacy specially High Performance Liquid Chromatography (HPLC), using mobile phase metanol : buffer potassium dyhidrogen phosphate 0,01 M (70:30) pH 6,0 and stationary phase C18 Symmetry (150 mm x 4,6 mm) with particle size 5mm, flow rate 1,0 mL/minute, injection volume 10,0 mL and measured at wavelength 247 nm. Analytical results showed that the placebo did not gived any analytical respons in selectivity test. Accuracy which know as  % recovery showed the average of % recovery 99,31% (98,70 – 100,44%), range between 80%-120%. Linearity at consentration range 70% - 130% with coefficient correlacy (r)  0,99924. The result of precision which is repeatability with average of % RSD 0,25%.  Based on t value and F value on intermediate precision showed that there is no differently result gived by the analytical methode with different analyst and time. Stability test solution and mobile phase composition with % bias £ ± 2% and %RSD £ 2%. Based on the analytical methode validation result the determination of Ambroxol Hydrochloride in Cystelis® tablet with high performace liquid chromatography we can conclude that this analytical methode is valid to implemented in daily inspection at Quality Control laboratory PT. Armoxindo Farma Kata kunci : Validation, Analytical methode, Ambroxol Hydrochloride, HPLC
The Role of Ziswaf To Improve Economic Equality in West Nusa Tenggara Titin Agustina; Dewi Apriyani; Gaoz Rozi Fahraini; Siti Nur Hidayati
International Journal of Economics and Management Sciences Vol. 1 No. 3 (2024): August : International Journal of Economics and Management Sciences
Publisher : Asosiasi Riset Ekonomi dan Akuntansi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ijems.v1i3.124

Abstract

This research aims to examine the role of ZISWAF (Zakat, Infaq, Sadaqah, and Waqf) in economic equality in the province of West Nusa Tenggara (NTB) using a qualitative approach. ZISWAF is seen as a financial instrument that has great potential for reducing economic disparities between community groups in NTB. A qualitative approach is used to understand the impact of ZISWAF's contribution to economic equality and the factors that influence its implementation. The research results show that ZISWAF has a significant role in economic equality in NTB. Through fund distribution, economic empowerment programs, and infrastructure development, ZISWAF can reduce economic disparities between community groups.
Sosialisasi Dampak Narkoba Terhadap Kesejahteraan Ekonomi dan Strategi Pencegahannya Bagi Pelajar di Desa Muer Kecamatan Plampang Feri Irawan; Tesa Eli Saputri; Muhammad Nur Ilham; Dewi Apriyani; Saindra; Handody Risky
Lumbung Ngabdi: Jurnal Pengabdian Masyarakat Vol. 2 No. 3 (2024): Desember
Publisher : Pusat Kajian dan Pengembangan Publikasi Ilmiah Institut Agama Islam Hamzanwadi Nahdlatul Wathan Lombok Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51806/ngabdi.v2i3.22

Abstract

Penyalahgunaan narkoba merupakan salah satu permasalahan serius yang mengancam masa depan generasi muda, termasuk pelajar di wilayah pedesaan seperti Desa Muer, Kecamatan Plampang. Kegiatan Sosialisasi ini bertujuan untuk memberikan edukasi kepada pelajar mengenai dampak negatif narkoba terhadap kesejahteraan ekonomi dan strategi pencegahannya sejak dini. Metode yang digunakan dalam kegiatan ini adalah sosialisasi secara langsung melalui penyampaian materi, diskusi interaktif, dan media edukatif seperti video dan poster. Hasil kegiatan menunjukkan bahwa para pelajar memiliki antusiasme tinggi dan terjadi peningkatan pemahaman terhadap bahaya narkoba, terutama kaitannya dengan penurunan kualitas hidup dan kerugian ekonomi. Kegiatan ini diharapkan dapat menumbuhkan kesadaran serta membentuk sikap pelajar untuk menjauhi narkoba dan menjalani kehidupan yang lebih sehat dan produktif. Sosialisasi ini juga menjadi langkah awal dalam menciptakan lingkungan sekolah yang aman dan bebas dari penyalahgunaan narkoba
ANALISIS KONSEP, IMPLEMENTASI, DAN DAMPAK PENDIDIKAN NILAI DALAM KURIKULUM NASIONAL: SEBUAH STUDI KEPUSTAKAAN Ani Khasbiyah; Dewi Apriyani
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 4 (2025): Volume 10. No4, Desember 2025.
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i4.38993

Abstract

National education currently faces complex challenges in the globalization era, where technological advancements often outpace the emotional and moral maturity of the younger generation. The phenomenon of character degradation and the erosion of cultural identity necessitates a reinforcement of value education, which is frequently sidelined by purely academic targets. This study aims to deeply analyze the concept, implementation strategies, and impact of value education within the Indonesian national curriculum, as well as conduct a comparative study with education systems in developed countries. Employing a qualitative approach with a library research method, this study examines literature related to educational policies, pedagogical theories, and global practices. The results indicate that the implementation of value education in Indonesia does not stand alone but is integrated through the synergy of the "Tri Pusat Pendidikan" (school, family, community) and internalized within various subjects and school culture. Comparative analysis reveals significant philosophical differences: while Finland is based on trust and flexibility, and Japan emphasizes strict discipline through moral subjects (Doutoku), Indonesia is characterized by a foundation of religious values and the spirit of mutual cooperation (gotong royong/Pancasila). The study concludes that value education is not merely a curriculum supplement, but a fundamental instrument to control the flow of globalization and ensure the educational process continues to humanize individuals. Its long-term impact is the formation of a civilized, tolerant society and a workforce with high integrity to support sustainable national development.