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This Author published in this journals
All Journal Nusantara Medical Science Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Efendi Lukas
Unknown Affiliation
Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Vascular Endothelial Growth FactorC Serum and Endostatin Serum as Predictors of Lympho Vascular Invasion in Early Stage Cervical Cancer Andhinna Rusmardiani; Syahrul Rauf; Efendi Lukas
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.671 KB) | DOI: 10.32771/inajog.v5i2.529

Abstract

Objective: To determine the relationship of Vascular Endothelial Growth Factors-C (VEGF-C), endostatin and the ratio of VEGF-C/ endostatin with limfo vascular invasion in patient with early stage cervical cancer. Methods: This study used a cross sectional method. Samples were all patients with early stage cervical cancer who came to the several teaching hospitals of Obstetrics and Gynecology Department Universitas Hasanuddin Medical Faculty that meet the criteria, then we measured the levels of VEGF-C and endostatin. Results: We get 30 women with cervical carcinoma. The results showed that the serum levels of VEGF-C was higher in limfo vascular invasion positive (p = 0.017); the ratio of VEGF-C/ endostatin higher in limfo vascular invasion positive (p = 0.004); whereas serum levels of endostatin did not differ significantly in limfo vascular invasion positive or negative (p = 0.522). Conclusion: The level of VEGF-C and VEGF-C/ endostatin ratio was higher in patients with early stage cervical cancer with positive LVSI than negative LVSI. [Indones J Obstet Gynecol 2017; 5-2: 105-109] Keywords: cervix uteri cancer, endostatin, limfo vascular invasion, VEGF-C
Twin Reversed Arterial Perfusion Sequence (TRAPS): A Case Report Astari, Prilly; Efendi Lukas
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42368

Abstract

Introduction and importance: Acardiac twins are a complication of monozygotic twin pregnancies. Twin Reversed Arterial Perfusion Sequence (TRAPS) is reported to occur in approximately 1% of monochorionic twin pregnancies and 1 in 35,000 pregnancies. The objective is to provide a brief description of acardiac twins. Presentation of case: A 25-year-old multigravida, 35/36 weeks of twin pregnancy. On ultrasound examination of acardiac twins, no heart structure, head bones, and sternum were found, and the shape of the fetus was unclear. Vaginal delivery was carried out; the first live female baby was born, followed by the acardiac baby. The acardiac baby is seen to have imperfect development of the head and upper extremities, Spina bifida, deformity of the lower extremities, Phocomelia of the lower limb, and Split foot. After 9 days, the baby's condition improved, and she was allowed to go home. Discussion: TRAPS's etiology and pathophysiological mechanisms are still poorly understood. Ultrasound findings show an absent or non-functioning heart in one twin, malformation with cystic hygroma, and generalized edema. The first baby (donor twin) was born prematurely, weighing 2200 grams, and there were no signs of heart failure, while the second baby (acardiac) was born weighing 1050 grams. Current therapy for acardiac twins aims to prevent congestive heart failure in the donor twin and stop blood flow to the acardiac twin. Conclusions: Early diagnosis of abnormalities in monochorionic pregnancy using ultrasound in the first trimester plays a role in assessing the prognosis for the viability of the pregnancy.
Co-Authors Andhinna Rusmardiani Astari, Prilly Syahrul Rauf