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Vascular Endothelial Growth FactorC Serum and Endostatin Serum as Predictors of Lympho Vascular Invasion in Early Stage Cervical Cancer Andhinna Rusmardiani; Syahrul Rauf; Efendi Lukas
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.671 KB) | DOI: 10.32771/inajog.v5i2.529

Abstract

Objective: To determine the relationship of Vascular Endothelial Growth Factors-C (VEGF-C), endostatin and the ratio of VEGF-C/ endostatin with limfo vascular invasion in patient with early stage cervical cancer. Methods: This study used a cross sectional method. Samples were all patients with early stage cervical cancer who came to the several teaching hospitals of Obstetrics and Gynecology Department Universitas Hasanuddin Medical Faculty that meet the criteria, then we measured the levels of VEGF-C and endostatin. Results: We get 30 women with cervical carcinoma. The results showed that the serum levels of VEGF-C was higher in limfo vascular invasion positive (p = 0.017); the ratio of VEGF-C/ endostatin higher in limfo vascular invasion positive (p = 0.004); whereas serum levels of endostatin did not differ significantly in limfo vascular invasion positive or negative (p = 0.522). Conclusion: The level of VEGF-C and VEGF-C/ endostatin ratio was higher in patients with early stage cervical cancer with positive LVSI than negative LVSI. [Indones J Obstet Gynecol 2017; 5-2: 105-109] Keywords: cervix uteri cancer, endostatin, limfo vascular invasion, VEGF-C
Human Papilloma Virus Selftesting as an Alternative Method for Cervical Cancer Screening Richard Chandra; Syahrul Rauf; Umar Malinta
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.036 KB) | DOI: 10.32771/inajog.v5i2.531

Abstract

Objective: To determine the level of acceptance of self Human Papilloma Virus (HPV) examination and to compare the level of sensitivity and specificity of self HPV examination with Fluid Based Cytology on precancerous cervical lesion and cervical cancer. Methods: The analytical method used in this research was cross sectional with purposive sampling. This study is conducted at Wahidin Sudirohusodo Hospital and its affiliation from October 2014 to May 2015 with 101 subjects. The data measurement used self HPV examination tool and fluid based cytology kit. The data collected through questionnaires before and after the examination. The laboratory examination was carried out using the way of HPV Genotyping primary system (MY09/11) method Wl LTS-06, which is able to detect 35 types of HPV viruses. Results: A total of 101 subjects were involved in this study. The subjects were divided into two groups: the abnormal and normal group (n - 50/51). The acceptance level of self HPV examination was 62.37% (n = 63/101). Majority of subjects (88.21%) were ready to repeat the same examination in the future. The level of sensitivity and specificity for self HPV were (56% (95%CI (41.25 - 70.01%)) vs 98% (95%CI (89.55 - 99.95%)), p=<0.000001, while the level of sensitivity and specificity for fluid based cytology were (40% (95%CI (26.41 - 54.82%)) vs 98% (95%CI (89.35 - 99.95%)), p=0.000002. Conclusion: HPV self-testing is very potential to be used as an alternative method for cervical cancer screening. [Indones J Obstet Gynecol 2017; 5-2: 114-119] Keywords: cervical cancer, cervical cancer screening, human papilloma virus, sensitivity, specificity
EFFECT OF INTERACTIVE PREGNANCY EDUCATION (IPE) ON STRESS LEVELS AMONG PRIMIGRAVID TRIMESTER III PREGNANT WOMEN Elli Hidayati; Syahrul Rauf; Mochammad Hatta; Sonny T. Lisal; Fatimah; Hamidah
Muhammadiyah International Public Health and Medicine Proceeding Vol. 4 No. 1 (2024): PROCEEDING MUHAMMADIYAH INTERNATIONAL PUBLIC HEALTH AND MEDICINE CONFERENCE - F
Publisher : Fakultas Kesehatan Masyarakat Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61811/miphmp.v4i1.658

Abstract

The Infant Mortality Rate (IMR) is an indicator in determining the health level of a country. Infant mortality is caused by various health problems, especially since the gestation period, even starting before the gestation period. Stress during pregnancy affects the motor, cognitive and emotional development of the baby. This study aims to determine the effect of Interactive Pregnancy Education (IPE) on levels in third trimester primigravida pregnant women. This research is a quasi-experimental study using a nonequivalent control group design. This research was conducted in the Kemayoran and Cempaka Putih Community Health Centers in DKI Jakarta from December 2021 to completion. The samples were 30 third trimester primigravida pregnant women for the intervention and control groups. Data were analyzed using the Mann Whitney and Wilcoxon tests with SPSS 22 software. The results showed that there was a significant difference between the median stress scores in the control group before and after the median decreased after the intervention and the difference in the median stress scores before and after the intervention in the intervention group was greater than the control group, which decreased to 6.50. This shows that IPE is effective in reducing stress in pregnant women who have previously had stress with high stress scores.