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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Sienny Linawaty
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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ANGKA BANDING APO B/APO A-I PADA GEJALA KORONER AKUT Sienny Linawaty; JB. Suparyatmo; Tahono Tahono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.436

Abstract

Coronary Artery Disease has a high prevalence and is frequently occurred and associated with the high mortality and morbidity. Dyslipidemia is one of the risk factors of Coronary Heart Disease (CHD). ApoB contained in very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), LDL and small dense LDL (sd-LDL), with one molecule of apoB in each particle. Apo A-I is the major apolipoprotein in HDL particles. The ratio of apoB/apoA-I is a balance between apoB-containing particles and potentially atherogenic apoA-I that is antiaterogenik. This study is carried to know the determination whether there are differences between apoB/ apoA-I ratio in patients dyslipidemia with ACS and non ACS. The research used a cross-sectional study design with patients dyslipidemia subjects suffering Acute Coronary Syndrome (ACS) and non ACS who enter to the Laboratory of Pathology Clinic at Dr. Moewardi Hospital between July and November 2011. To determine the pattern of data distribution, the researchers used Kolmogorov Smirnov test. For the analysis of differences in mean apoB/apoA-I ratio in the two population groups is used the T test, using a computer program, with the significance level p<0.05, 95% confidence interval. From 74 samples examined the mean age is 56.42 year old. This patients consisted of 33 males (44.6%) and 41 women (55.4%). All subjects are grouped into two groups, dyslipidemia ACS and non dyslipidemia ACS. The results showed apoB/apoA-I ratio significantly different in patients with dyslipidemia with ACS and non ACS. The mean apoB/apoA-I ratio of women and men subjects in both groups, including groups at high risk of myocardial myokard and higher than the cut-off ratio of apoB/ apoA-I (men 0.9 and women 0.8). It can be concluded that the apoB/apoA-I ratio of women and men subjects in both groups, included the high risk category for infarct myokard although lipid abnormalities are still not demonstrated to the risk of infarct myokard.
Serum Soluble Endoglin (sEng) as A Predictor of Preeclampsia Severity Mustiqa Febriniata; Dian Ariningrum; Sienny Linawaty
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2403

Abstract

 Preeclampsia is new-onset hypertension in pregnancy after 20 weeks of gestation. It is characterized by proteinuria or organ damage. Laboratory tests with high sensitivity and specificity in predicting severe preeclampsia are currently lacking due to the pathogenesis of preeclampsia which is still unclear. SEng (Soluble Endoglin), a glycoprotein expressed by syncytiotrophoblasts, is released into the maternal circulation in preeclampsia, acting as an anti-angiogenic through its binding to TGF-beta which then inhibits the vasodilation pathway. This angiogenic imbalance subsequently results in endothelial dysfunction and multiorgan damage. We investigated serum sEng as a predictor of severe preeclampsia by analyzing the risk factors of preeclampsia. An observational analytic study using a cross sectional design was conducted on pregnant women diagnosed with preeclampsia based on POGI (Perkumpulan Obstetri dan Ginekologi Indonesia) treated in Dr. Moewardi Hospital from June to July 2024. Serum samples of sEng were collected and examined using the sandwich ELISA method and then cut-off was determined. The multivariate multiple logistic regression with the backward stepwise method analysis obtained that sEng level with a cut-off point of 23.38 ng/mL could be used as an independent biomarker to predict severe preeclampsia, while other risk factors of preeclampsia including maternal age, obesity, parity, history of preeclampsia, and gestational age could not predict the severity of preeclampsia (p <0.05). Further study is needed with a larger sample size involving multiple centers to generalize the outcomes and top analyze other preeclampsia risk factors.
Co-Authors Dian Ariningrum JB. Suparyatmo Mustiqa Febriniata Tahono Tahono