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All Journal Nexus Kedokteran Komunitas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Mustiqa Febriniata
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Hubungan Lama Penggunaan Kontrasepsi Oral Kombinasi dengan Tekanan Darah pada Wanita Usia Subur Febriniata, Mustiqa; ., Widardo; Febrinasari, Ratih Puspita
Nexus Kedokteran Komunitas Vol 1, No 2 (2012): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.113 KB)

Abstract

Background: Combined oral contraception is one of contraception methods that contains estrogen and progesterone. Both of that hormones have an effect on blood pressure levels because of the using duration of combined oral contraception, Body Mass Index (BMI), and acceptor age. The purpose of this research is to analyze the correlation between the using duration of combined oral contraception and blood pressure levels among fertile women in Jaten area, Karanganyar. Methods: This research used observational cross sectional analytic approach method. The population were fertile women who use combined oral contraception. The total sample were 48 patients who appropriate with inclusion and exclusion criterias. The data were collected by kuesioner, interview, anthropometry measurement, and blood pressure direct measurement. Those variables such as the using duration of combined oral contraception, blood pressure levels (systolic and diastolic), age, and body mass index (BMI) were analyzed using Kolmogorof-Smirnov’s test of normality and linear regression analysis using SPSS 16 for Windows. Results: The result of simple statistic test using linear regression showed the correlation significancy between the using duration of combined oral contraception and blood pressure levels, both systolic (p=0,004) and diastolic (p=0,012). Conclusions: There is a correlation between the using duration of combined oral contraception and blood pressure levels among fertile women. Keywords: The using duration of combined oral contraception, Blood Pressure, Age, Body mass index  
Hubungan Lama Penggunaan Kontrasepsi Oral Kombinasi dengan Tekanan Darah pada Wanita Usia Subur Mustiqa Febriniata; Widardo .; Ratih Puspita Febrinasari
Nexus Kedokteran Komunitas Vol 1, No 2 (2012): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.113 KB)

Abstract

Background: Combined oral contraception is one of contraception methods that contains estrogen and progesterone. Both of that hormones have an effect on blood pressure levels because of the using duration of combined oral contraception, Body Mass Index (BMI), and acceptor age. The purpose of this research is to analyze the correlation between the using duration of combined oral contraception and blood pressure levels among fertile women in Jaten area, Karanganyar. Methods: This research used observational cross sectional analytic approach method. The population were fertile women who use combined oral contraception. The total sample were 48 patients who appropriate with inclusion and exclusion criterias. The data were collected by kuesioner, interview, anthropometry measurement, and blood pressure direct measurement. Those variables such as the using duration of combined oral contraception, blood pressure levels (systolic and diastolic), age, and body mass index (BMI) were analyzed using Kolmogorof-Smirnovs test of normality and linear regression analysis using SPSS 16 for Windows. Results: The result of simple statistic test using linear regression showed the correlation significancy between the using duration of combined oral contraception and blood pressure levels, both systolic (p=0,004) and diastolic (p=0,012). Conclusions: There is a correlation between the using duration of combined oral contraception and blood pressure levels among fertile women. Keywords: The using duration of combined oral contraception, Blood Pressure, Age, Body mass index
Serum Soluble Endoglin (sEng) as A Predictor of Preeclampsia Severity Mustiqa Febriniata; Dian Ariningrum; Sienny Linawaty
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2403

Abstract

 Preeclampsia is new-onset hypertension in pregnancy after 20 weeks of gestation. It is characterized by proteinuria or organ damage. Laboratory tests with high sensitivity and specificity in predicting severe preeclampsia are currently lacking due to the pathogenesis of preeclampsia which is still unclear. SEng (Soluble Endoglin), a glycoprotein expressed by syncytiotrophoblasts, is released into the maternal circulation in preeclampsia, acting as an anti-angiogenic through its binding to TGF-beta which then inhibits the vasodilation pathway. This angiogenic imbalance subsequently results in endothelial dysfunction and multiorgan damage. We investigated serum sEng as a predictor of severe preeclampsia by analyzing the risk factors of preeclampsia. An observational analytic study using a cross sectional design was conducted on pregnant women diagnosed with preeclampsia based on POGI (Perkumpulan Obstetri dan Ginekologi Indonesia) treated in Dr. Moewardi Hospital from June to July 2024. Serum samples of sEng were collected and examined using the sandwich ELISA method and then cut-off was determined. The multivariate multiple logistic regression with the backward stepwise method analysis obtained that sEng level with a cut-off point of 23.38 ng/mL could be used as an independent biomarker to predict severe preeclampsia, while other risk factors of preeclampsia including maternal age, obesity, parity, history of preeclampsia, and gestational age could not predict the severity of preeclampsia (p <0.05). Further study is needed with a larger sample size involving multiple centers to generalize the outcomes and top analyze other preeclampsia risk factors.
Co-Authors Dian Ariningrum Ratih Puspita Febrinasari Ratih Puspita Febrinasari Sienny Linawaty Widardo .