Yelsa Yulanda Putri
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Perbedaan Rasio Kolesterol Total/ HDL Kelompok Kontrol dan Kelompok Diet Tinggi Minyak Sawit pada Tikus Wistar Yelsa Yulanda Putri; Ellyza Nasrul; Susila Sastri
Jurnal Kesehatan Andalas Vol 3, No 3 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i3.185

Abstract

AbstrakRasio kolesterol total/ HDL merupakan variabel lipoprotein terbaik dalam memprediksi risiko penyakit kardiovaskular. Peningkatan risiko penyakit kardiovaskular dapat disebabkan oleh tingginya kadar kolesterol serum. Minyak sawit mengandung 50% asam lemak jenuh dan 50% asam lemak tidak jenuh. Tujuan penelitian ini adalah mengetahui perbedaan rasio kolesterol total/ HDL antara kelompok kontrol dengan kelompok diet tinggi minyak sawit pada tikus. Penelitian ini adalah eksperimental dengan pendekatan post test only control group design. Sampel penelitian terdiri dari 10 ekor tikus Wistar jantan yang dibagi menjadi kelompok kontrol (K) dan kelompok perlakuan (P). Diet tinggi minyak sawit (minyak sawit 42.5%, 3ml/hari) diberikan pada kelompok P selama empat minggu. Analisis data menggunakan uji t independent. Hasil penelitian menunjukkan terdapat perbedaan peningkatan yang tidak bermakna antara kelompok P dan kelompok K pada rerata kolesterol, yaitu 63.66±9.9(P) 57.39±3.28(K) (p>0.05), rerata HDL 19.44±3.99(P) 17.64±2.00(K) (p>0.05), dan rerata rasio kolesterol total/ HDL 3.26±0.24 (P) 3.31±0.32 (K) (p>0.05). Kesimpulan penelitian ini adalah kadar kolesterol total, HDL, dan rasio kolesterol total/ HDL pada kelompok kontrol dan kelompok diet tinggi minyak sawit tidak berbeda.Kata kunci: diet tinggi minyak sawit, kolesterol, HDL, rasio kolesterol/ HDLAbstractThe ratio of total cholesterol/ HDL is the lipoprotein variables best predict the risk of cardiovascular disease . The increased risk of cardiovascular disease can be caused by high levels of cholesterol exciting. Palm oil contains 50% saturated fatty acids and 50% unsaturated fatty acids. The purpose of this study was to know the differences ratio of total cholesterol/ HDL between the control group and high palm oil diet group in rats. This research was experimental with post-test only control group. The study sample consisted of 10 male Wistar rats were divided into control group (K) and treated group (P). High-palm oil diet (50% palm oil, 3ml/day) was given to the group P for four weeks. Analysis of data using independent t test. The results showed there were no significant differences in improvement between groups P and groups K in mean cholesterol, 63.66 ± 9.9 (P) 57.39 ± 3.28 (K) in (p> 0.05), mean HDL 19.44 ± 3.99 (P) 17.64 ± 2.00 (K) in (p> 0.05), and the mean ratio of total cholesterol/ HDL 3.26 ± 0.24 (P) 3.31 ± 0.32 (K) in (p>0.05). The conclusion of this study is total cholesterol, HDL, and the ratio of total cholesterol/ HDL in the control group and the high palm oil diet group did not differ.Keywords: high palm oil diet, cholesterol, HDL, ratio of cholesterol/HDL
The Impact of Pulmonary Rehabilitation on Advanced Stage Lung Cancer Patients Receiving Chemotherapy or Radiotherapy: A Systematic Review and Meta-analysis Putri, Yelsa Yulanda; Suyastri, Suyastri; Maryani, Siti
Majalah Kedokteran Andalas Vol. 48 No. 3 (2025): MKA July 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1229-1242.2023

Abstract

Objective: This study aims to analyze the efficacy of pulmonary rehabilitation on exercise capacity, lung function, and quality of life (QoL) in advanced lung cancer. Method: This Systematic Review and meta-analysis were conducted based on Randomized Clinical Trials and Prospective articles obtained through searches in PubMed, Google Scholar, Europe PMC, and Cochrane Library. The review focuses on the predetermined topic. The quality of the study was assessed by the Jadad scale for clinical trial studies and Newcastle Ottawa Scale for Cohort. Statistical analysis was done using Review Manager 5.4 software. Result: A total of 6 RCT studies with 251 participants were included in this meta‐analysis. Patients with lung cancer who have received chemotherapy and or radiation therapy and undergo pulmonary rehabilitation programs have a significant impact on exercise capacity The Six Minute Walk Test (MD=72.06  [95% CI 25.45, 118.67], p=0.002), Forced Expiratory Volume (MD=13.03 [95% CI 0.18,25.89], p= 0.05), Forced Vital Capacity (MD=12.44 [95% CI 0.58, 24.30], p= 0.04) dan HRQoL Functional Assessment of Cancer Therapy-Lung Cancer Subscale (MD=1.64  [95% CI 0.07,3.21], p= 0.04). Conclusion: Our study suggests that pulmonary rehabilitation impact exercise capacity (6MWT), improvement in lung function, and quality of life.Keywords: Lung cancer; Pulmonary Rehabilitation; Chemotherapy; Radiotherapy