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All Journal Journal of Medicine and Health Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Cermin Dunia Kedokteran Journal of Medicine and Health Cermin Dunia Kedokteran Jurnal Info Kesehatan
Uleng Bahrun
Bagian Ilmu Patologi Klinik, Fakultas Kedokteran Universitas, Hasanuddin, Makassar, Sulawesi Selatan, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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ANALYSIS OF VITAMIN D IN PATIENTS WITH DIABETES MELLITUS TYPE 2 Arfandhy Sanda; Uleng Bahrun; Ruland DN. Pakasi; Andi Makbul Aman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1360

Abstract

Diabetes Mellitus is a metabolic disease which is still a public health problem till now. World Health Organization (WHO) and International Diabetes Federation (IDF) predict an increase in the number of diabetics which become one of the global threats. Some evidences showed that vitamin D deficiency might influenced in pathogenesis of Type 2 Diabetes Mellitus that caused by insulin resistence and dysfunction of pancreatic beta cell. The objectives of this study is To analyze Vitamin D levels in Type 2 Diabetes Patients that consist of prediabetic group, controlled Type 2 Diabetes Mellitus Group, and uncontrolled Type 2 Diabetes Mellitus. The method used is a cross sectional study. During the study period, a total of 93 samples were obtained which met the study criteria. The sample consist of 33 prediabetic subjects, 30 controlled Type 2 DM subejcts, and 30 uncontrolled Type 2 DM. The study sample consist of 49(52,7%) men and 44(47,3%) women with minimum age 20 years and maximum 79 years (mean 56,59+12,15 years). The minimum HbA1c level was 4,8% and the maximum level was 12,9% (mean 6,95+1,81%). The minimum Vitamin D level was 9,07 ng/ml dan  the maximum level was 66,49 ng/ml (mean 26,85+9,30 ng/ml). Kruskal Wallis test showed p value=0,132, Spearman correlation test showed p value>0,05. The clonclusion from this study, there is no significant correlation between vitamin D level and type 2 Diabetes Melllitus consist of Prediabetic group, controlled Type 2 Diabetes Mellitus, and uncontrolled type 2 Diabetes Mellitus.
Analisis Hubungan Berbagai Indeks Obesitas dengan Kadar Interleukin-6 pada Subjek Obesitas dan Non-obesitas Sentral Asni R Tina; Liong B Kurniawan; Uleng Bahrun
Journal of Medicine and Health Vol. 3 No. 2 (2021)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v3i2.3502

Abstract

Obesitas sentral adalah penumpukan lemak pada tubuh bagian abdomen yang diakibatkanoleh jumlah lemak berlebih. Interleukin-6 merupakan sitokin yang diekskresi oleh jaringanadiposa dan kadarnya meningkat pada obesitas sentral. Tujuan penelitian ini adalah menganalisishubungan indeks obesitas dengan kadar interleukin-6 pada obesitas sentral serta non obesitassentral. Responden dalam penelitian berjumlah 75 subjek yang di antaranya 20 subjek laki-lakidan 20 subjek perempuan obesitas sentral serta 20 subjek laki-laki dan 15 subjek perempuan nonobesitas sentral. Metode yang digunakan dalam penelitian ini adalah observasional. Hasilpenelitian menunjukkan terdapat perbedaan bermakna antara indeks massa tubuh (p < 0,001),lingkar pinggang (p < 0,001), lemak tubuh (p = 0,003) dan lemak viseral (p < 0,001) subjekobesitas sentral dengan obesitas non sentral. Hasil penelitian juga membuktikan bahwa IndeksMassa Tubuh (IMT), Lingkar Pinggang (LP), lemak tubuh dan lemak viseral tidak berkorelasidengan IL-6 pada subjek laki-laki dan pada subjek perempuan hanya lemak viseral yangberkorelasi dengan IL-6 (p = 0,043; r = 0,343). Simpulan penelitian, terdapat korelasi signifikanantara lemak viseral dan kadar IL-6 pada subjek perempuan obesitas sentral dan non obesitassentral. Kata kunci: obesitas sentral; lemak viseral; lemak tubuh; interleukin-6
Hasil Positif Palsu Tes Morfin pada Skrining Urin Narkoba Diduga Akibat Rifampisin Liong Boy Kurniawan; Yuyun Widaningsih; Nurhayana Sennang; Uleng Bahrun; Mansyur Arif
Cermin Dunia Kedokteran Vol 42, No 1 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i1.1054

Abstract

Hasil positif palsu pada tes skrining urin narkoba dengan metode imunologi jarang terjadi. Pemastian hasil memerlukan anamnesis yang baik mengenai konsumsi obat dan konfirmasi dengan tes yang lebih spesifik, biasanya dengan metode kromatografi gas/spektrometri massa. Beberapa substansi dilaporkan dapat menyebabkan hasil positif palsu. Dilaporkan satu kasus laki-laki 18 tahun dengan hasil positif morfin (tes urin narkoba) menggunakan metode imunologi kompetitif. Setelah anamnesis ketat diketahui bahwa pasien tersebut dalam pengobatan rifampisin selama 6 bulan karena tuberkulosis dan tidak pernah mengkonsumsi narkoba. Sampel urin berwarna kemerahan (hasil ekskresi metabolit rifampisin melalui urin). Diperlukan konfirmasi pasti dengan metode lebih spesifik dengan kromatografi gas/spektrometri massa (standar baku emas).False positive reports on urine drug screening using immunoassay method are rare. Confirmation should be done through detailed anamneses on consumed drugs that may interfere result and perform test with more specific method such as gas chromatography/mass spectrometry (GC-MS). Some substances have been reported as the causes of false positive test. A case reported to have positive on morphine urine drug test using competitive immunoassay from an 18 year-old male. The patient was on 6-month rifampicin treatment for tuberculosis and had no history of substance abuse. The urine sample was reddish due to rifampicin metabolite excretion. Confirmation with gas chromatography/mass spectrometry method should be performed as gold standard.
Penanda Tumor untuk Diagnosis Karsinoma Kaput Pankreas Irmayanti -; Uleng Bahrun; A.M. Luthfi Parewangi; Ibrahim Abd. Samad
Cermin Dunia Kedokteran Vol 45, No 3 (2018): Muskuloskeletal
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i3.192

Abstract

Pendahuluan. Karsinoma kaput pankreas cenderung terjadi pada usia lanjut dan merupakan penyebab kematian keempat akibat keganasan. Diagnosis karsinoma kaput pankreas ditegakkan berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan penunjang laboratorium dan radiologi. Kasus. Karsinoma kaput pankreas pada pasien ini menyebabkan obstruksi aliran empedu, sehingga terjadi kolestasis disertai peningkatan CEA dan CA 19-9 yang sangat tinggi.
Penanda Tumor untuk Diagnosis Karsinoma Kaput Pankreas Irmayanti; Uleng Bahrun; A.M. Luthfi Parewangi; Ibrahim Abd. Samad
Cermin Dunia Kedokteran Vol. 45 No. 3 (2018): Muskuloskeletal
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i3.820

Abstract

Pendahuluan. Karsinoma kaput pankreas cenderung terjadi pada usia lanjut dan merupakan penyebab kematian keempat akibat keganasan. Diagnosis karsinoma kaput pankreas ditegakkan berdasarkan anamnesis, pemeriksaan fisis, pemeriksaan penunjang laboratorium dan radiologi. Kasus. Karsinoma kaput pankreas pada pasien ini menyebabkan obstruksi aliran empedu, sehingga terjadi kolestasis disertai peningkatan CEA dan Ca 19-9 yang sangat tinggi.   Introduction. Head pancreatic carcinoma tends to occur during old age and it is the fourth leading cause of death due to malignancy. Diagnosis is made based on history, physical examination, laboratory investigations and radiology. Case. The head pancreatic carcinoma in this patient led to bile flow obstruction, causing cholestasis accompanied with pronounced increased CEA and Ca 19-9 value.
Analisis Hubungan Berbagai Indeks Obesitas dengan Kadar Interleukin-6 pada Subjek Obesitas dan Non-obesitas Sentral Asni R Tina; Liong B Kurniawan; Uleng Bahrun
Journal of Medicine and Health Vol 3 No 2 (2021)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v3i2.3502

Abstract

Obesitas sentral adalah penumpukan lemak pada tubuh bagian abdomen yang diakibatkanoleh jumlah lemak berlebih. Interleukin-6 merupakan sitokin yang diekskresi oleh jaringanadiposa dan kadarnya meningkat pada obesitas sentral. Tujuan penelitian ini adalah menganalisishubungan indeks obesitas dengan kadar interleukin-6 pada obesitas sentral serta non obesitassentral. Responden dalam penelitian berjumlah 75 subjek yang di antaranya 20 subjek laki-lakidan 20 subjek perempuan obesitas sentral serta 20 subjek laki-laki dan 15 subjek perempuan nonobesitas sentral. Metode yang digunakan dalam penelitian ini adalah observasional. Hasilpenelitian menunjukkan terdapat perbedaan bermakna antara indeks massa tubuh (p < 0,001),lingkar pinggang (p < 0,001), lemak tubuh (p = 0,003) dan lemak viseral (p < 0,001) subjekobesitas sentral dengan obesitas non sentral. Hasil penelitian juga membuktikan bahwa IndeksMassa Tubuh (IMT), Lingkar Pinggang (LP), lemak tubuh dan lemak viseral tidak berkorelasidengan IL-6 pada subjek laki-laki dan pada subjek perempuan hanya lemak viseral yangberkorelasi dengan IL-6 (p = 0,043; r = 0,343). Simpulan penelitian, terdapat korelasi signifikanantara lemak viseral dan kadar IL-6 pada subjek perempuan obesitas sentral dan non obesitassentral. Kata kunci: obesitas sentral; lemak viseral; lemak tubuh; interleukin-6
Penanda Tumor untuk Diagnosis Karsinoma Kaput Pankreas Irmayanti; Uleng Bahrun; A.M. Luthfi Parewangi; Ibrahim Abd. Samad
Cermin Dunia Kedokteran Vol 45 No 3 (2018): Muskuloskeletal
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i3.820

Abstract

Pendahuluan. Karsinoma kaput pankreas cenderung terjadi pada usia lanjut dan merupakan penyebab kematian keempat akibat keganasan. Diagnosis karsinoma kaput pankreas ditegakkan berdasarkan anamnesis, pemeriksaan fisis, pemeriksaan penunjang laboratorium dan radiologi. Kasus. Karsinoma kaput pankreas pada pasien ini menyebabkan obstruksi aliran empedu, sehingga terjadi kolestasis disertai peningkatan CEA dan Ca 19-9 yang sangat tinggi.   Introduction. Head pancreatic carcinoma tends to occur during old age and it is the fourth leading cause of death due to malignancy. Diagnosis is made based on history, physical examination, laboratory investigations and radiology. Case. The head pancreatic carcinoma in this patient led to bile flow obstruction, causing cholestasis accompanied with pronounced increased CEA and Ca 19-9 value.
N Terminal-Pro Brain Natriuretic Peptide (Nt–ProBNP) Pada Penderita Hipertensi Derajat 1 Dan Derajat 2 Supriati Wila Djami; Mansyur Arif; Uleng Bahrun
JURNAL INFO KESEHATAN Vol 17 No 1 (2019): Jurnal Info Kesehatan
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol17.Iss1.232

Abstract

The level of N Terminal – Pro Brain Natriuretic Peptide was independently associated with an increased risk of hypertension. This study aimed to determine the difference of NT-proBNP serum levels and the correlation between the levels of NT-proBNP in patients with hypertension stage 1 and stage 2. This research was conducted at RSUP dr. Wahidin Sudirohusodo in August -September 2018. The research was conducted at Dr. Wahidin Sudirohusodo RSUP from August through September 2018. The study used a cross-sectional design with a total of 72 hypertensive patients, who had met the inclusive criteria. NT-proBNP levels were measured using the ELISA (Enzyme-Linked Immunosorbent Assay) method. The collected data is processed using Mann Whitney Different Test and Spearman's rho Correlation Test. The study results indicated that the level of NT-proBNP in the hypertensive patients with stage 2 (172.85 + 316.26) was higher and significantly different (p = <0.001) compared to hypertensive patients stage 1 (34.98 + 28.99). NT-proBNP levels were higher in the hypertensive group of >6 years (247.83+361.01) than in the hypertensive group <6 years (62.79+164.66), statistically there were significant differences between the two groups (p=0.010). There was in a significant correlation between the levels of NT-proBNP in hypertensive patients, stage 1 and stage 2 (p = 0.862) even though it showed significantly different results.
Co-Authors A.M. Luthfi Parewangi Andi Makbul Aman Arfandhy Sanda Asni R Tina Ibrahim Abd. Samad Irmayanti Irmayanti - Liong B Kurniawan Liong Boy Kurniawan, Liong Boy Mansyur Arif Mansyur Arif Nurhayana Sennang Ruland DN. Pakasi Supriati Wila Djami Yuyun Widaningsih