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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) eJournal Kedokteran Indonesia
Diana Aulia
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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IDIOPATHIC THROMBOCYTOPENIC PURPURA Alvina .; Diana Aulia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1036

Abstract

Idiopathic thrombocytopenic purpura is an autoimunne disease with low platelet count and bleeding manifestation like purpura, echymosis, petechie, mucosa membrane bleeding. The cause of ITP is platelet coated with specific thrombocyte autoantibody. Idiopathicthrombocytopenic purpura is classified as primary or secondary. The primary ITP is classified as acute and chronic.. Children and adultonset idiopathic thrombocytopenic purpura are different. An Acute ITP can be found in children and chronic onset can be found in adult.The duration of bleeding may help to distinguish acute and chronic idiopathic thrombocytopenic purpura. The diagnosis of idiopathicthrombocytopenic purpura remains one of exclusion after other thrombocytopenic disease are ruled out based on history and needanamnesa, physical examination, thrombocyte count, perifer blood smear examination, bone marrow smear examination. The treatmentis to raise the platelet count into a hemostatically safe range. This article presented a study case of idiopathic thrombocytopenic purpuraon an old woman with DIC which caused her death.
The Role of Neutrophil Lymphocyte Ratio , Vitamin D, and NGAL as Cardiovascular Disease Marker in Chronic Kidney Disease Sri Suryo Adiyanti; Yusra Yusra; Suzanna Immanuel; Diana Aulia; Fify Henrika; July Kumalawati
eJournal Kedokteran Indonesia Vol 9, No. 3 - Desember 2021
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (154.048 KB) | DOI: 10.23886/ejki.9.35.192-6

Abstract

Chronic kidney disease (CKD) patients have higher risk to develop cardiovascular disease (CVD) than non-CKD patients. Neutrophil lymphocyte ratio (NLR) in CKD patients reflects inflammation status and role as complementary prognostic marker to evaluate cardiovascular risk in stage 3 to 5 CKD. High prevalence of vitamin D deficiency commonly found in CKD patients, leads to endothelial dysfunction and increase inflammation. NGAL is used as renal injury biomarker but nowadays NGAL has been known plays important role in CVD pathophysiology. CVD identification in CKD patients is necessary to obtain CVD risk and to stratify mortality earlier in CKD patients. This study aimed to obtain the differences and continued to obtain cut off of NLR, vitamin D and NGAL in CKD patients undergoing hemodialysis (HD) with and without CVD if the differences was significantly. A cross-sectional study was conducted in dr. Cipto Mangunkusumo National Hospital Jakarta, in December- February 2020. Total subjects were 83, consists of two groups with and without the CVD. There were no significant differences of NLR and vitamin D in CKD patients undergoing hemodialysis (HD) with and without CVD. The significant difference was found only in NGAL with cut off 5.64 ng/ml. NLR was lower, meanwhile vitamin D and NGAL were higher in CKD patients undergoing HD with and without CVD.
Co-Authors Alvina . Fify Henrika, Fify Kumalawati, July Sri Suryo Adiyanti Suzanna Immanuel YUSRA YUSRA