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All Journal Jurnal Ilmiah Farmasi Farmasyifa Bandung Conference Series: Pharmacy
Esti Rachmawati Sadiyah
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULASI MINUMAN TEPUNG CACING TANAH (Lumbricus rubellus Hoffmeister) TERGANULASI DISERTAI UJI DAYA INGATNYA PADA MENCIT JANTAN Gita Cahya Eka Darma; Wulandari Putri Saraswati; Esti Rachmawati Sadiyah
Jurnal Ilmiah Farmasi Farmasyifa Vol 1, No 1 (2018)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v1i1.3117

Abstract

Protein is a chemical compound that is important for body. Earthworm (Lumbricus rubellus Hoffmeister) is known to have high protein content that can be used as alternative protein. This study aimed to determine the activity of earthworm flour in improving memory on mice (Mus musculus) and its formulation in the form of granulated earthworm flour beverage. Memory activity test was performed using Y labyrinth with observation parameter in the form of latency time (second) and number of errors. The optimum dose resulted from the memory test is 325 mg/kg BB which is equivalent to the use of two times the preparation containing 1.25 g of earthworm flour. Optimization of suspending agent was done singly and combination and obtained 3 formulae combination of best suspending agent and then continued to granulation proces. Formula evaluation conducted were organoleptic test, moisture, flow properties, particle size distribution, reconstitution time, redispersion time, sedimentation volume, viscosity, stability, hedonic test and quantitative analysis of protein content. Based of evaluation, one optimum formula was chosen which was, combination of 0,5% CMC-Na, 0,1% Sodium Alginate, 3,75% turmeric powder, 10% white sugar, 3% talk and Mg stearat 1%. The protein contained in the best formula was 26.03%
UJI AKTIVITAS SITOTOKSIK EKSTRAK ASETON DAUN SIRIH (Piper betle L.) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Raihan Dzaky Ath Thaariq; Esti Rachmawati Sadiyah; Sri Peni Fitrianingsih
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8947

Abstract

Daun sirih (Piper betle L.) merupakan tumbuhan yang tersebar luas diseluruh Indonesia. Daun sirih (Piper betle L.) telah digunakan secara empiris dan telah terbukti memiliki berbagai macam aktivitas farmakologi. Penelitian ini bertujuan untuk mengatahui aktivitas sitotoksik dari ekstrak aseton daun sirih dengan metode BSLT. Hasil uji fitokimia pada ekstrak aseton daun sirih mengandung senyawa flavonoid, steroid, dan saponin yang berpotensi memiliki aktivitas sitotoksik. Kelompok uji penelitian ini yaitu ekstrak aseton daun sirih dengan konsentrasi 10 ppm, 100 ppm, 250 ppm, 500 ppm, dan 1000 ppm. Kontrol negatif yang digunakan pada penelitian ini yaitu DMSO yang ditambahkan kedalam air laut. Parameter pengamatan uji aktivitas sitotoksik dengan metode BSLT yaitu kematian larva setelah pengujian selama 24 jam. Nilai LC50 dari hasil uji yaitu sebesar 30,7777 ppm, sehingga menunjukkan bahwa ekstrak aseton daun sirih memiliki aktivitas sitotoksik. Betel leaf (Piper betle L.) is a plant that is widespread throughout Indonesia. Betel leaf (Piper betle L.) has been used empirically and has been shown to have various pharmacological activities. This study aims to determine the cytotoxic activity of betel leaf acetone extract using the BSLT method. Phytochemical test results on betel leaf acetone extract contained flavonoids, steroids, and saponins which have the potential to have cytotoxic activity. The test group for this research was betel leaf acetone extract with concentrations of 10 ppm, 100 ppm, 250 ppm, 500 ppm, and 1000 ppm. The negative control used in this study was DMSO added to seawater. The parameter observed for the cytotoxic activity test with the BSLT method was the death of the larvae after 24 hours of testing. The LC50 value of the test results was 30.7777 ppm, indicating that the acetone extract of betel leaf had cytotoxic activity.
Co-Authors Gita Cahya Eka Darma Raihan Dzaky Ath Thaariq Sri Peni Fitrianingsih Wulandari Putri Saraswati