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Efek hidrogel getah jarak cina (Jatropha multifida Linn.) berbasis karagenan kappa dan karagenan iota terhadap penyembuhan luka tikus wistar jantan Lestari, Fetri; Darma, Gita Cahya Eka; Kartika, Rikka
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Jatropha multifida Linn. latex has been reported in many study for its activities to treats wound. Preparation of hydrogels containing 3% ofÂ Jatropha multifida Linn. latex with variety of base polymers kappa carrageenan and iota carrageenanÂ was conducted and met good characteristics. This study aimed to evaluate effect of both hydrogels to promote wound healing in Wistar rats. Tests carried out on five groups of rats with 1.5 cm diameter of wound in the back area, consisting of a control group, two test groups were each treated by 2% kappa carrageenan-based hydrogel (kappa-hydrogel group) and 2% iota carrageenan-based hydrogel (iota-hydrogel group) of the latex, and two groups were each given a different hydrogel base according to type of hydrogel tested. Effect on wound healing was assessed by parameters including wound drying period, scab forming period, and the change in diameter of the wound. Results show kappa-hydrogel group achieve the most rapid wound healing compare to the control group significantly (p<0,05) and the iota-hydrogel group on wound drying period (16.6 Â± 2.2 hours) and scab forming period (92.6 Â± 2.2 hours). Kappa-hydrogel group also show best changes in diameter of the wound at day 21 which is reduced to 0.02 Â± 0.03 cm, compare to the control group and iota-hydrogel group. As a conclusion, the 2% kappa carrageenan-based hydrogel containing 3% ofÂ Jatropha multifida Linn. latex produce better effect to promote wound healing than iota carrageenan-based hydrogel in this study.Â

Efek hidrogel getah jarak cina (Jatropha multifida Linn.) berbasis karagenan kappa dan karagenan iota terhadap penyembuhan luka tikus wistar jantan Fetri Lestari; Gita Cahya Eka Darma; Rikka Kartika
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Jatropha multifida Linn. latex has been reported in many study for its activities to treats wound. Preparation of hydrogels containing 3% ofÂ Jatropha multifida Linn. latex with variety of base polymers kappa carrageenan and iota carrageenanÂ was conducted and met good characteristics. This study aimed to evaluate effect of both hydrogels to promote wound healing in Wistar rats. Tests carried out on five groups of rats with 1.5 cm diameter of wound in the back area, consisting of a control group, two test groups were each treated by 2% kappa carrageenan-based hydrogel (kappa-hydrogel group) and 2% iota carrageenan-based hydrogel (iota-hydrogel group) of the latex, and two groups were each given a different hydrogel base according to type of hydrogel tested. Effect on wound healing was assessed by parameters including wound drying period, scab forming period, and the change in diameter of the wound. Results show kappa-hydrogel group achieve the most rapid wound healing compare to the control group significantly (p<0,05) and the iota-hydrogel group on wound drying period (16.6 Â± 2.2 hours) and scab forming period (92.6 Â± 2.2 hours). Kappa-hydrogel group also show best changes in diameter of the wound at day 21 which is reduced to 0.02 Â± 0.03 cm, compare to the control group and iota-hydrogel group. As a conclusion, the 2% kappa carrageenan-based hydrogel containing 3% ofÂ Jatropha multifida Linn. latex produce better effect to promote wound healing than iota carrageenan-based hydrogel in this study.Â

The effect of particle size on dissolution rate of fast dissolving oral film containing diclofenac sodium Fitrianti Darusman; Nyayu Ista Yulita; Gita Cahya Eka Darma
Pharmaciana Vol 10, No 2 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Diclofenac sodium is a Non-Steroidal Anti Inflammatory Drugs that if being taken orally have the side effects of peptic ulcers and undergone the first pass metabolism, and also included in the Biopharmaceutics Classification System class 2 which resulted in the low rate of dissolution. This study aims to determine the influence of particle size reduction on the dissolution rate of diclofenac sodium in the form of an FDOF dosage. The formation of diclofenac sodium nanoparticles is carried out by ionic gelation method using chitosan and sodium tripolyphosphate as a crosslinker in various ratios characterized by Particle Size Analyzer and Scanning Electron Microscopy, then it is incorporated into the form of an FDOF that were prepared by solvent casting method at a dose of 12.5 mg using variations concentration of SSG as superdisintegrant and PEG 400 as plasticizer. From the research results, diclofenac sodium nanoparticles are formed in the ratio of chitosan-sodium tripolyphosphate 6:1, have a size of 804 nm and spherical-shaped. The best FDOF dosage formula is F8 containing HPMC E5 LV 35% as the film forming agent, SSG 8% as superdisintegrant and PEG 400 10% as plasticizer.Â FDOF formula containing diclofenac sodium nanoparticles has a slightly bitter taste, disintegration time less than one minute, surface pH around 7 (neutral), drug content that meets the requirements of the range of determination which is 93.24 Â± 0.96, the cumulative amount of drug dissolved in the 28th minute is higher by 88.45% compared to FDOF containing diclofenac sodium raw material, which is only 70.0%.

FORMULASI MINUMAN TEPUNG CACING TANAH (Lumbricus rubellus Hoffmeister) TERGANULASI DISERTAI UJI DAYA INGATNYA PADA MENCIT JANTAN Gita Cahya Eka Darma; Wulandari Putri Saraswati; Esti Rachmawati Sadiyah
Jurnal Ilmiah Farmasi Farmasyifa Vol 1, No 1 (2018)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v1i1.3117

Protein is a chemical compound that is important for body. Earthworm (Lumbricus rubellus Hoffmeister) is known to have high protein content that can be used as alternative protein. This study aimed to determine the activity of earthworm flour in improving memory on mice (Mus musculus) and its formulation in the form of granulated earthworm flour beverage. Memory activity test was performed using Y labyrinth with observation parameter in the form of latency time (second) and number of errors. The optimum dose resulted from the memory test is 325 mg/kg BB which is equivalent to the use of two times the preparation containing 1.25 g of earthworm flour. Optimization of suspending agent was done singly and combination and obtained 3 formulae combination of best suspending agent and then continued to granulation proces. Formula evaluation conducted were organoleptic test, moisture, flow properties, particle size distribution, reconstitution time, redispersion time, sedimentation volume, viscosity, stability, hedonic test and quantitative analysis of protein content. Based of evaluation, one optimum formula was chosen which was, combination of 0,5% CMC-Na, 0,1% Sodium Alginate, 3,75% turmeric powder, 10% white sugar, 3% talk and Mg stearat 1%. The protein contained in the best formula was 26.03%

FARMASI PLASMA Gita Cahya Eka Darma
Jurnal Ilmiah Farmasi Farmasyifa Vol 5, No 1 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v5i1.8846

In the last decade, the world has recognized the existence of a new branch of science in the field of medicine that uses plasma technology in the process, namely plasma medicine. A science that examines plasma as a drug in the form of a medical device or method in medical technology. The use of the term plasma medicine into Indonesian is one of the objectives of this study, because if it is translated into "plasma medicine". This study intends to provide an explanation of plasma (physics), plasma medicine and then an approach to the term into Indonesian becomes Plasma Pharmacy. The results of studies that have been carried out on researches in this new branch of science show similarities to the scope of the pharmaceutical field. Plasma pharmacy refers to the use of plasma that is applied to one or all of the stages in the manufacture of drugs (including drug raw materials, namely active ingredients, additives and packaging), functional food and cosmetics, in addition to plasma itself acting as a drug in the form of a medical device. So that the term plasma pharmacy can be used as an Indonesian vocabulary in explaining plasma medicine

Formulasi Sediaan Cuka Buah Kopi Menggunakan Ragi (Saccharomyces cerevisiae) dan Bakteri (Acetobacter aceti) Fathan Said R; Gita Cahya Eka Darma
Jurnal Riset Farmasi Volume 1, No. 1, Juli 2021, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Abstract. Indonesia is the third largest coffee producing country in the world, with a variety of compounds that are beneficial to the body. Vinegar fermentation is one way to add value to the benefits of fruits and vegetables because it can form useful new chemical compounds. Vinegar has a variety of benefits that have been studied such as reducing hyperglycemia, hyperinsulinemia, hyperlipidemia and obesity. Previous research in 2013 had made acetic acid from Arabica coffee pulp waste. This study aims to obtain a coffee fruit vinegar formula that conforms to the quality standards of acetic acid SNI 01-4371-1996. The material used is whole coffee with a two-stage fermentation method, namely alcohol fermentation using S. cerevisiae for 4 days and vinegar fermentation using A. aceti for 3 days. The results showed that the formula with 25% coffee fruit and 20% sugar is the best formula compared to other formulas with organoleptic test results in brown, sour and sweet taste and a little distinctive aroma of coffee, 5.03% acetic acid content, 0% alcohol content, pH 3,242. Abstrak. Indonesia merupakan negara ketiga penghasil kopi terbesar di dunia, dengan berbagai kandungan senyawa yang bermanfaat bagi tubuh. Fermentasi cuka merupakan salah satu cara untuk menambah nilai manfaat dari buah dan sayur karena dapat membentuk senyawa kimia baru yang bermanfaat. Cuka memiliki berbagai manfaat yang telah diteliti seperti menurunkan hiperglikemia, hiperinsulinemia, hiperlipidemia dan obesitas. Penelitian sebelumnya pada tahun 2013 telah dilakukan pembuatan asam asetat dari limbah cair kulit kopi arabika. Penelitian ini bertujuan untuk mendapatkan formula cuka buah kopi yang sesuai standar mutu asam asetat SNI 01-4371-1996. Bahan yang digunakan adalah buah kopi secara utuh dengan metode fermentasi dua tahap yaitu fermentasi alkohol menggunakan S. cerevisiae selama 4 hari dan fermentasi cuka menggunakan A. aceti selama 3 hari. Hasil penelitian menunjukan bahwa formula dengan 25% buah kopi dan 20% gula merupakan formula terbaik dibandingkan dengan formula lain dengan hasil uji organoleptis berwarna coklat, rasa asam dan manis serta sedikit aroma khas kopi, kadar asam asetat 5,053%, kadar alkohol 0%, pH 3,242.

Penerapan Metode Plasma Pijar Korona dalam Penyerapan Minyak Lemon (Citrus limon L Osbeck) Siska Ayuningtyas Purnama; Gita Cahya Eka Darma
Jurnal Riset Farmasi Volume 2, No. 1, Juli 2022, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

ABSTRACT: Body odor is caused by the bacteria Staphylococcus epidermidis which can cause sweat to smell bad. Textiles can be used as a medium to help make it easier to treat certain diseases with the right procedure, in this case an undershirt is used with the addition of lemon essential oil so that it has an antibacterial effect. Addition using the plasma method. This study aims to obtain the most effective method. This research uses experimental research. Lemon essential oil solution was used for antibacterial activity with 8, 9 and 10% variance with the time and distance used in plasma was 4 cm and 4 minutes. The results showed that in the physical evaluation (SEM) using plasma the surface became rougher, in the chemical evaluation (FTIR) there was still limonene compound, the antibacterial evaluation of the inhibition zone was 11.57 mm without plasma treatment and using 13.53 mm plasma treatment and evaluation of the stability of the inhibition zone in plasma treatment with 6 washings of 15.18 mm and 12 washings of 14.65 mm and without plasma treatment with 6 washings of 15.45 mm and 12 washings of 12.43 mm. The most effective method for absorbing lemon essential oil is the plasma method followed by immersion. ABSTRAK: Bau badan ini disebabkan karena adanya bakteri Staphylococcus epidermidis yang dapat menyebabkan keringat menjadi berbau tidak sedap. Tekstil dapat digunakan sebagai media untuk membantu mempermudah mengobati penyakit tertentu dengan prosedur yang tepat, dalam hal ini digunakan kaos dalam dengan penambahan minyak essensial lemon sehingga memiliki efek antibakteri. Penambahan dengan menggunakan metode plasma. Penelitian ini bertujuan untuk memperoleh metode yang paling efektif. Penelitian ini menggunakan penelitian eksperimental. Larutan minyak essensial lemon digunakan untuk aktivitas antibakteri dengan variansi 8, 9 dan 10% dengan waktu dan jarak yang digunakan pada plasma adalah 4 cm dan 4 menit. Hasil penelitian menunjukkan bahwa pada evaluasi fisika (SEM) dengan menggunakan plasma permukaannya menjadi lebih kasar, pada evaluasi kimia (FTIR) masih terdapat senyawa limonene, evaluasi antibakteri zona hambat pada tanpa perlakuan plasma 11,57 mm dan menggunakan perlakuan plasma 13,53 mm dan evaluasi stabilitas zona hambat pada perlakuan plasma dengan 6 kali pencucian 15,18 mm dan 12 kali pencucian 14,65 mm dan tanpa perlakuan plasma dengan 6 kali pencucian 15,45 mm dan 12 kali pencucian 12,43 mm. Metode yang paling efektif untuk menjerap minyak essensial lemon adalah metode plasma yang dilanjutkan dengan pencelupan.

Titik Kritis Granul Terapung dan Granul Tenggelam Fildzah Nabilla Putri; Gita Cahya Eka Darma; Yani Krishnamurti
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Feed is food given to livestock, and is a source of energy and substances for the growth and life of living things. Natural feed is food that fish eat naturally. Artificial feed is feed made by humans which is made from a mixture of natural ingredients or processed materials which are then processed and made in a certain form so as to create an attraction for fish to eat them. According to the method of administration, fish feed is divided into 2 types, namely sinking pellets and floating pellets. The two species differ in the time it takes for the feed to sink. The sinking pellet type will quickly sink to the bottom of the pond and the floating pellet type can float on the surface of the water for up to several hours. Granules can float because there are pores in the granule that occur due to friction of the material carried by the extruder with the tube wall and compacted at the end of the extruder by the extrusion process which is a combination of water, heat, and high pressure where water vapor is trapped in the retrogradation process, during the drying process will come out and leave empty spaces or pores. Abstrak. Pakan adalah makanan yang diberikan kepada ternak, dan merupakan sumber energi dan zat bagi pertumbuhan dan kehidupan makhluk hidup. Pakan alami adalah pakan yang dimakan ikan secara alami. Pakan buatan adalah pakan yang dibuat oleh manusia yang dibuat dari campuran bahan alami atau bahan olahan yang kemudian dilakukan proses pengolahan serta dibuat dalam bentuk tertentu sehingga menciptakan daya tarik ikan untuk memakannya. Menurut metode pemberiannya, pakan ikan dibagi menjadi 2 jenis yaitu pelet tenggelam dan pelet terapung. Kedua jenis ini berbeda dalam waktu yang diperlukan untuk pakan dapat tenggelam. Jenis pelet tenggelam dengan cepat akan tenggelam ke dasar kolam dan jenis pelet terapung dapat mengapung di permukaan air sampai beberapa jam. Granul bisa terapung karena ada pori-pori dalam granul yang terjadi karena gesekan dari bahan yang dibawa oleh ekstruder dengan dinding tabung dan dipadatkan diujung ekstruder dengan proses ekstruksi yang merupakan kombinasi antara air, panas, dan tekanan tinggi dimana uap air yang terperangkap pada proses retrogradasi, saat proses pengeringan akan keluar dan meninggalkan ruang kosong atau pori-pori.

Formulasi Basis Sabun Cair sebagai Metode Penghantaran Sediaan Antiseptik Erni Johan; Gita Cahya Eka Darma; Ratih Aryani
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Most people use liquid soap as a cleanser in their daily lives. Chemicals known as antiseptics are used to stop or eliminate bacteria from growing on living tissues, thus preventing skin infections. By preventing the growth of bacteria, antiseptic liquid soap lowers the risk of infection and the development of diseases. Flavonoids and polyphenols are active substances and have antibacterial properties. A preparation called antiseptic liquid soap is used to clean the skin's surface of debris and bacteria. Its objectives are to determine the liquid soap formula that satisfies the requirements and to ascertain the liquid soap's antibacterial activity toward the germs Escherichia coli and Staphylococcus aureus. The method carried out is the evaluation of the soap base and the test of antibacterial activity on the soap base. In formula 3 in accordance with SNI 2017, which is in the form of a homogeneous liquid, different aromas, pH 8.98, viscosity 2570 cPs, type weight 1.042, foam stability 69.5%, free fatty acids 0.20%, and alkali-free 0.096%, and has antibacterial activity with a strong category, namely Escherichia 19.37 mm and Staphylococcus aureus 20.15 mm. Abstrak. Sabun cair adalah sediaan pembersih yang cukup banyak digunakan dalam kehidupan sehari-hari. Antiseptik adalah senyawa kimia yang digunakan untuk menghambat atau membunuh mikroorganisme pada jaringan hidup, serta dapat mencegah infeksi kulit. Sabun cair antiseptik berfungsi untuk menghambat pertumbuhan bakteri dan mengurangi resiko infeksi serta timbulnya penyakit. Senyawa aktif yang mempunyai aktivitas antibakteri yaitu flavonoid dan polifenol. Sabun cair antiseptik berfungsi sebagai sediaan yang dapat menghilangkan kotoran dan mikroorganisme pada permukaan kulit. Tujuannya adalah untuk mengetahui formula basis sabun cair yang memenuhi persyaratan dan untuk mengetahui aktivitas antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dalam basis sabun cair. Metode yang dilakukan yaitu evaluasi basis sabun dan uji aktivitas antibakteri pada basis sabun. Pada pembuatan sediaan sabun cair formula 3 dengan menghasilkan evaluasi yang sesuai dengan SNI 2017 yaitu berbentuk cairan yang homogen, berbau khas, pH 8,98, viskositas 2570 cPs, bobot jenis 1,042, stabilitas busa 69,5%, asam lemak bebas 0,20% dan alkali bebas 0,096% serta memiliki aktivitas antibakteri dengan kategori kuat yaitu Escherichia coli 19,37 mm dan Staphylococcus aureus 20,15 mm.

Formulasi Basis Sheet Mask Bioselulosa Nathania Ramadhanty Nuzirwan; Gita Cahya Eka Darma; Anan Suparman
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. There are environmental aggressors such as UV-rays and micro/nano particles indoors or outdoors can cause damage to skin collagen/elastin that triggers premature aging. Based on these things, there is a demand for innovative cosmetic product formulations, capable of neutralizing the negative effects of UV rays, and made from natural ingredients. Biocellulose sheet masks are obtained from natural sources, namely the bacterium Acetobacter xylinum which produces acid from glucose and synthesizes cellulose. The purpose of this study was to obtain a biocellulose sheet mask formulation with best characteristics, as well as to compare the ability to moisturize biocellulose sheet mask and non-woven sheet mask. The formulation of the biocellulose sheet mask has a good characteristics. The results of comparison between biocellulose sheet masks and non woven sheet masks show that biocellulose sheet masks has the best skin moisturizing effect. Abstrak. Agresor lingkungan seperti sinar UV dan mikro/nano partikulat terdapat di luar maupun di dalam ruangan dapat menyebabkan kerusakan kolagen/elastin kulit yang pemicu penuaan dini. Berdasarkan hal-hal tersebut terbentuklah permintaan untuk formulasi produk kosmetik yang inovatif, mampu menetralisir efek negatif sinar UV, dan dibuat dari bahan-bahan alami. Sheet mask bioselulosa diperoleh dari sumber alami yaitu bakteri Acetobacter xylinum yang menghasilkan asam dari glukosa dan mensintesis selulosa. Tujuan dari penelitian ini yaitu untuk mendapatkan formulasi sheet mask bioselulosa dengan karakteristik baik, serta mengetahui perbandingan kemampuan melembabkan sheet mask bioselulosa dan sheet mask non woven. Formulasi sheet mask bioselulosa yang dihasilkan memiliki karakteristik baik. Hasil komparasi sheet mask bioselulosa dan sheet mask non woven diketahui bahwa sheet mask bioselulosa memiliki efek melembabkan yang lebih baik dibandingkan dengan sheet mask non woven.

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