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All Journal The Avicenna Medical Journal
Flori R. Sari
Universitas Islam Negeri Syarif Hidayatullah Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Potential Protective Role of 14-3-3 Protein in Pathological Cardiac Hypertrophy Through The Regulation of Endoplasmic Reticulum Stress: Role of Calreticulin Flori R. Sari; Rajarajan A Thandavarayan; Vivian Soetikno
The Avicenna Medical Journal Vol 2, No 2 (2021)
Publisher : Faculty of Medicine, UIN (State Islamic University) Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v2i2.25441

Abstract

Introduction: 14-3-3 protein plays an important role in protecting cardiac cells from hypertrophy and endoplasmic reticulum stress during pressure overload elicited by aortic banding (AB) surgery; however, the relation among these protective roles is largely unknown. Methods: We investigated the in vivo role of 14-3-3 protein in two protocols involving C57/BL-6 mice and dominant negative (DN) 14-3-3η mice subjected to three- or seven-days pressure overload stimulation by applying AB surgery. The protein expressions of cardiac hypertrophy and ER stress markers, including atrial natriuretic peptide (ANP), galectin-3, glucose-regulated protein (GRP)78, calreticulin as well as 14-3-3 protein was analyzed by western blot. Results: Three- or seven-day pressure overload stimulation significantly increased the heart weight/body weight (HW/BW) ratio; cardiomyocyte diameter; and the protein expression levels of ANP, GRP78 as well as 14-3-3 in the C57/BL-6 mice. Partial inactivation of 14-3-3 protein in the DN 14-3-3η mice significantly increased the protein expression of ANP, Galectin-3, GRP78, and calreticulin after three- or seven-days AB surgery. Conclusion: These results suggest that 14-3-3 protein, as a molecular chaperone, protects against pathological cardiac hypertrophy, at least in part, by maintaining the normal ER function through the regulation of GRP78 and calreticulin.
Role of Physician’ Characteristics in Drug Prescription: Evaluation From Drug Database in Improving Prescribing Regulation Flori R. Sari; Saiful Anwar; Risahmawati Risahmawati; Marita Fadhilah; Fika Ekayanti
The Avicenna Medical Journal Vol 4, No 1 (2023)
Publisher : Faculty of Medicine, UIN (State Islamic University) Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v4i1.29878

Abstract

Introduction: Drugs prescribing is the most important skill for physicians and is strictly regulated by the government. However, factors that contribute to the drug prescribing are not determined yet. The aim of this study is to identify the possible role of physician character in drug prescribing at primary health centers (PHC).Method: A cross-sectional study was purposely done over fourteen-days at PHCs of Tangerang Districts. All prescriptions (n=2410) registered in the PHC drug-alert system (CIDIA Database) were analyzed descriptively.Result: From 2410 prescriptions registered in the PHC drug alert system, 15% prescriptions were prescribed by male physicians and 85% by the females. During the study, there were 964 drugs prescribed by 6 male physicians, 161 drugs per physician in average. There were 5584 drugs prescribed by 12 female physicians, 465 drugs per physician on average. Female physicians tended to prescribe 4 or more drugs compared to its male counterpart at 14% (p=0.006). However, there was no significant difference of drug interactions observed in the prescriptions prescribed by male or female physicians (p>0.05).Discussion: We identified that physician characteristics including gender played a significant role in the drug prescribing process especially the number of drugs prescribed. Therefore, considering gender differences in prescribing drugs may help the PHCs to improve a better management in drug safety and to comply with the government prescribing regulation.
Co-Authors Fika Ekayanti Marita Fadhilah Rajarajan A Thandavarayan Risahmawati Risahmawati SAIFUL ANWAR Vivian Soetikno