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Sri Rejeki Handayani

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Author-ID : 3553424

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Aktivitas Antiparkinson Ekstrak Rimpang Temulawak (Curcuma Xathorriza Roxb.) Pada Tikus Putih (Rattus Norvegicus) Galur Sprague Dawley Yang Diinduksi Haloperidol Nofika Dwi Anitasari; Jason Merari Peranginangin; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Temulawak (Curcuma xathorriza Roxb.) Is a plant that contains curcumin. Curcumin in ethanol extracts of temulawak rhizome has been shown to penetrate the blood brain barrier and has a neuroprotective effect that can reduce the symptoms of parkinsonism caused by haloperidol. This study aims to determine the activity of ethanol extract of temulawak rhizome in reducing symptoms of Parkinson's and know the effective dose of temulawak rhizome extract in reducing symptoms of Parkinson's.This study used 35 rats divided into 7 groups, each group consisting of 5 rats. Group 1 was given aquadestilata. Group II was given a solution of 0.5% CMC-Na p.o. Group III was given levodopa dose 27 mg/kgbb. Group IV was given vitamin E dose of 180 IU/kgbb. Groups V, VI, VII were given the temulawak extracts of 120, 240 and 480 mg/kgbb. 45 minutes later all groups except group I were given haloperidol 2 mg/kgbb i.p. The catalepsy and rota rod tests were performed on days 0, 4, 7, 11 and 14.From catalepsy test of temulawak extract dose 120, 240, 480 mg/kgbb respectively showed activity of catalepsy decrease equal to 23,25; 52,28 and 58,56 %. While in rota rod test shows the activity increase time of latency consecutively equal to 26,87; 30,34 and 34,58 %. The effective dose of temulawak rhizome extract in reducing symptoms of Parkinson's is a dose of 240 mg / kgbb

Aktivitas Antiparkinson Ekstrak Rosella (Hibiscus Sabbdariffa L.) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Sprague Dawley Yang Diinduksi Haloperidol Irsyad Rizky Ardhianta; Jasson Merari Peranginangin; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Parkinson's disease is a disease caused by decreased dopamine levels in pars compacta substantia nigra. Dopamine is closely related to antioxidants, because antioxidants can reduce free radicals that damage dopamine-producing cells. Rosella is one plant that has antioxidant content of flavonoids, saponins, and alkaloids. The purpose of this study was to determine the effect of roselle extract on the decrease of symptoms of Parkinson's disease.This research uses Sprague dawley rodents as 35 rats, divided into 7 groups. Group I (healthy control) was given aquadestillata po, group II (negative control) was given CMC-Na 0.5% po, group III (positive control I) was given levodopa 27 mg / kgbw po, group IV (positive control II) E 180 IU / kgbw rat po Groups V, VI, and VII were given 150 consecutive doses of rosella; 300; 600 mg / kgbw p.o. The whole group was induced with haloperidol at the 45th minute after treatment except in group I (healthy control). Then tested with a catalepsy bar test, recorded the latency time expressed in the score and rota test rod, recorded time latency in seconds on days 0, 4, 7, 11, and 14.The results showed that roselle extract gave antiparkinson effect on white rat of the haloperidol-induced Sprague dawley rod. The effective dose of rosella in reducing Parkinson's symptoms is 300 mg / kgbw

Aktivitas Antiparkinson Ekstrak Gambir (Uncaria Gambir Roxb.) Pada Tikus Putih (Rattus Norvegicus) Galur Sprague Dawley yang Diinduksi Haloperidol Lutfi Nofitasari; Jason Merari Peranginangin; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Parkinson disease is a disease that occurs due to damage to dopaminergic nerve cells in the brain which resulted in decreased dopamine production. Gambir is a dry extract made from the leaves of Uncaria gambier Roxb plant. Gambir contains flavonoids in the form of catechins not less than 90%, alkaloids and terpenoids. This study aims to determine the activity of gambir extract that can reduce the symptoms of Parkinson's in the male rats Sprague dawley induced haloperidol.Test animals of 35 rats divided into 7 groups. Group I (healthy control) was given aquadest orally, group II (negative control) was given a 0.5% CMC-Na solution, group III (positive control I) was given levodopa 27 mg / kgbb po, group IV (positive control II ) Were given vitamin E 180 IU / kgbb po Groups V, VI, and VII were given a dose of 70 consecutive gambir extracts; 140; 280 mg / kgbb. The whole group induced haloperidol 2 mg / kgbb i.p at the 45th minute after treatment except in the healthy group. Then the group was tested with a catalepsy bar test, recorded time latency expressed in scores and rota test rods, recorded time of latency in seconds on days 0, 4, 7, 11, and 14.The result of the research using catalepsy bar test method showed a decrease of catalepsy in gambir extract dose 70; 140; 280 mg / kgbb has a successive activity of 22.53; 52.50; 57.12%. While the results with rota rod test method showed% increase in time latency extract gambir respectively of 27.69; 35.75; 39.61%.

Uji Efektifitas Gel Ekstrak Sambung Nyawa (Gynura Procumbens (Lour.)Merr.) Terhadap Penyembuhan Luka Pada Kelinci Hiperglikemia Ganet Eko Pramukantoro; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.778

Hyperglycemia can inhibit the wounds healing process. Giving life-sustained leaf extract gel (Gynura procumbens (Lour.) Merr.) Is one of the options. The long-term goal of this study is to prove that the gel extract (Gynura procumbens (Lour.) Merr.) Leaf extract gel is able to heal wounds in hyperglycemic test animals. The specific target to be achieved is to obtain efficacious natural medicines to prevent the occurrence of diabetic wounds and to know the effective dosage of gel extract extract (Gynura procumbens (Lour.) Merr.) As a cure for diabetic wounds. This study used 5 white rabbits. Testing is done by making a wound on the back of DM alloxan-induced test animals. Wound healing activity is seen by dividing the backs of test animals into 5 parts which are treated according to their groups. The treatment group and the positive control group were applied with gel twice a day for 9 days and measured the length of the wound on days 1, 3, 5, 7, and 9. Diabetic wound healing activity was shown by calculating the wound length of each treatment and analyzed with the Anova test one way with a 95% confidence level. The results of the study showed that the formulation of life grafting gel extract based on CMC Na had good physical quality test results such as organoleptic color test according to the color of the extract, distinctive aroma of the life span leaf extract, viscous, homogeneous appearance, had a pH of 6. For the dispersion test , adhesion, and viscosity, each meets the desired requirements. The wound healing activity test showed that the grafted leaf extract with a concentration of 5% was able to heal the best, with a percentage of wound healing of 67.00%.

Co-Authors Ganet Eko P Irsyad Rizky Ardhianta Jason Merari Peranginangin Jasson Merari Peranginangin Lutfi Nofitasari Nofika Dwi Anitasari

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