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Analisis Pengendalian Persediaan Obat BPJS Kategori A(Always) Dan E (Esensial) Dengan Menggunakan Metode ABC, VEN Dan EOQ Di IFRS Bhayangkara Tingkat III Nganjuk Darmawan, Nopandi Wisnu; Peranginangin, Jason Merari; Herowati, Rina
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 6, No 1 (2021)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v6i1.38960

Abstract

Penelitian ini  membahas tentang tata kelola obat-obatan di Rumah Sakit dengan manajemen seleksi, pengadaan, distribusi dan penggunaan obat secara rasional yaitu tepat obat, dosis dan biaya. Pemilihan obat kategori AE, karena obat kategori AE memiliki tingkat kritis berdasarkan pada jumlah pemakaian tinggi dan dengan jumlah item obat yang banyak. Tujuan dilakukannya penelitian yaitu untuk melakukan analisa terhadap kendali obat BPJS kategori AE menggunakan ABC and   VEN method, menganalisa pengendalian ketersediaan obat obat BPJS dengan metode EOQ dan ROP dalam peningkatan obat menjadi efisien serta menganalisa tingkat pelayanan obat. Desain penelitian ini yaitu quasi experiment non-control. populasi semua obat BPJS yang ada di instalasi farmasi, sampel penelitaian adalah obat BPJS berdasarkan analisis metode ABC dan VEN kategori AE pada bulan Februari sampai Juli 2019. Untuk mengamati sert amengukur tingkat keefesienan  pada  pengendalian ketersediaan obat-obatan maka diberlakukan indikator nilai persediaan dan Customer servis level (tingkat pelayanan), penelitian yang sudah mendapatkan hasilnya, maka akan dilakukan pengujian statistik Paired t-Test. Dari uji analisis menggunakan metode ABC dan VEN dapat mengidentifikasi obat yang memerlukan pengendalian persediaan yang lebih ketat dan memprioritaskan 29  item obat BPJS kategori AE. Indikator nilai persediaan dengan penerapan metode EOQ dan ROP sebelum intervensi Rp. 403.114.341 dan setelah intervensi Rp. 331.170.915 dapat meningkatkan efesiensi pengelolaan obat BPJS dan menurunkan nilai persediaan sebesar Rp 71.943.426  berdasarkan hasil sebelum – sesudah intervensi menunjukkan hasil signifikan (0,043). Indikator tingkat pelayanan (customer servis level) sebelum intervensi 91,76% dan setelah intervensi 94,39% berdasarkan hasil sebelum – sesudah intervensi menunjukkan hasil signifikan (0,025). Penggunaan metode EOQ dan ROP memudahhkan dalam perencanaan dan pengadaan serta merupakan upaya pengontrolan dan pemantauan persediaan obat agar obat yang diberikan tepat waktu dan kekosongan persediaan obat dapat dihindari.
STRATEGI PERBAIKAN PELAYANAN KEFARMASIAN DAN PENGGUNAAN OBAT BERBASIS STANDAR AKREDITASI DENGAN METODE MATRIKS DI INSTALASI FARMASI RSU AULIA LODOYO BLITAR Desi Alviona; Jason Merari Peranginangin; Chairun
Jurnal Farmasi & Sains Indonesia Vol 1 No 2 (2018)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Abstract

Akreditasi merupakan penilaian KARS untuk meningkatkan keselamatan dan mutu pelayanan Rumah Sakit. Penelitian dilakukan di IFRSU Aulia Lodoyo Blitar yang merupakan Rumah Sakit tipe C, pada Maret 2017 lulus akreditasi paripurna sesuai standar akreditasi KARS versi 2012, secara garis besar standar pelayanan kefarmasian di Rumah Sakit belum sepenuhnya tercapai. Penelitian ini untuk mengetahui tingkat kesesuaian tujuh standar PKPO terhadap SNARS 2018 dan strategi perbaikan masalah menggunakan skala prioritas dengan metode matriks. Penelitian dianalisis deskriptif kuantitatif dan kualitatif. Pengumpulan data menggunakan kuesioner dan wawancara kepada Kepala IFRS serta observasi untuk mendukung kuesioner. Subyek penelitian yaitu Apoteker, TTK, dan administrasi farmasi. Hasil data diolah dalam bentuk tabel dan dilakukan perbaikan dengan skala prioritas masalah menggunakan metode matriks. Tingkat kesesuaian PKPO di IFRSU Aulia Lodoyo Blitar belum sepenuhnya memenuhi SNARS. Persentase didapatkan : pengorganisasian 67,2%, seleksi dan pengadaan 63,3%, penyimpanan 77,1%, peresepan dan penyalinan 74,7%, persiapan dan penyerahan 71,8%, pemberian obat 78,2%, pemantauan 62,2%. Strategi perbaikannya berdasarkan skala prioritas masalah menggunakan metode matriks : PKPO 7 pemantauan efek obat, PKPO 2 seleksi dan pengadaan, PKPO 1 pengorganisasian yang melakukan supervisi sesuai dengan penugasannya, PKPO 5 persiapan dan penyerahan obat, PKPO 4 peresepan dan penyalinan, PKPO 3 penyimpanan obat, dan PKPO 6 pemberian obat.
UJI AKTIVITAS INSEKTISIDA EKSTRAK ETANOL, FRAKSI n-HEKSAN, FRAKSI KLOROFORM, DAN FRAKSI AIR DARI BIJI PALA (Myristica fragrans Houtt) TERHADAP Anopheles aconitus Atalia Tamo Ina Bulu; Titik Sunarni; Jason Merari Peranginangin
Jurnal Farmasi & Sains Indonesia Vol 2 No 2 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Abstract

Nyamuk Anopheles aconitus merupakan salah satu vektor yang menularkan penyakit malaria. Salah satu cara mengendalikan populasi vektor adalah menggunakan insektisida. Tanaman obat dengan aktivitas insektisida dapat digunakan untuk mengendalikan populasi vektor malaria. Tujuan penelitian ini adalah untuk mengetahui apakah ekstrak etanol, fraksi n-heksan, fraksi kloroform dan fraksi air dari biji pala (Myristica fragrans Houtt) mempunyai aktivitas insektisida yang dinyatakan dengan KC50 dan LC50. Ekstraksi menggunakan metode maserasi kemudian dilanjutkan dengan fraksinasi. Hasil ekstrasi dan fraksinasi dibuat menjadi 4 seri konsetrasi yaitu 25 ppm, 50 ppm, 100 ppm dan 200 ppm. Pengujian dilakukan terhadap 20 ekor nyamuk Anopheles aconitus. Pengamatan dilakukan selama 20 menit untuk melihat knockdown dan 24 jam untuk melihat kematian nyamuk lalu dihitung KC50 dan LC50 menggunakan analisa probit. Hasil penelitian menunjukkan bahwa ekstrak etanol, fraksi n-heksan, fraksi kloroform dan fraksi air memiliki aktivitas insektisida. Fraksi n-heksan dari biji pala (Myristica fragrans Houtt) memiliki aktivitas yang paling tinggi. Nilai KC50 berturut-turut ekstrak etanol, fraksi n-heksan, fraksi kloroform dan fraksi air adalah 527,16 ppm; 326,72 ppm; 390,01 ppm; 525,19 ppm dan nilai LC50 berturut-turut adalah 489,56 ppm; 142,66 ppm; 281,58 ppm; 364,59 ppm terhadap nyamuk Anopheles aconitus.
UJI AKTIVITAS MINYAK ATSIRI KULIT BUAH JERUK NIPIS (Citrus aurantifolia, Swingle) DALAM SEDIAAN LOTION SEBAGAI REPELAN TERHADAP NYAMUK Aedes aegypti Dewi Ekowati; Ahmad Nuzulul Abid; Jason Merari P
Biomedika Vol 6 No 1 (2013): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.465 KB) | DOI: 10.31001/biomedika.v6i1.241

Abstract

Kulit buah jeruk nipis (Citrus aurantifolia, Swingle) merupakan salah satu familia Rutaceae yang mengandung minyak atsiri. Penelitian ini bertujuan untuk mengetahui aktivitas minyak atsiri sari kulit buah jeruk nipis sebagai penolak nyamuk (repelan) terhadap nyamuk Aedes aegepti yang dinyatakan denga EC90 dengan pembanding autan. Minyak atsiri kulit buah jeruk nipis diperoleh dengan cara destilasi air. Minyak atsiri yang didapat dari destilasi air kemudian dibuat lotion dengan konsentrasi 10%, 20% dan 40%. Pengamatan dilakukan selama 6 jam untuk mengetahui jumlah nyamuk yang hinggap pada ketiga konsentrasi, kemudian dihitung harga EC90 dengan menggunakan analisa probit. Pada penelitian ini diperoleh nilai EC90 67,00%. Hal ini menunjukkan bahwa pada konsentrasi 67,00% minyak atsiri dari kulit jeruk nipis sudah dapat menolak nyamuk 90% hewan uji.
Gambaran Penggunaan dan Penyimpanan Obat oleh Masyarakat di Kota Banjarmasin Tahun 2020 Melviani Melviani; Onny Ziasti Fricilia; Jason Merari Peranginangin; Felix Imanuel Rachman; Munawarah Munawarah
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2648

Abstract

The COVID-19 pandemic has spread throughout the world, including in Banjarmasin, South Kalimantan. People use some medicines to maintain their health. This study aimed to describe the use of drugs in the community and their use and storage during a pandemic. This research method used an observational research design with a cross-sectional approach, using the convenience sampling technique with the google form application. The community-based survey was conducted on 101 respondents representing the community in Banjarmasin City for the general population group. The study results were 2 types of drugs that were widely used by respondents, namely vitamin drugs (72.3%) and supplements (27.7%). Respondents already know how to use drugs according to how they are used (83.2%), and the survey shows excellent results where (90.1%) of respondents take drugs as recommended by health workers. As many as (64.4%) of respondents knew how to store medicines according to their storage and (90.1%) store them properly. The conclusion is that the use and storage have a big impact on the quality of the drug, which currently the most popular are vitamin and symptomatic drugs.
UJI DAYA ANTIINFLAMASI EKSTRAK ETANOLIK DAUN MONDOKAKI (Tabernaemontana divaricata, R.Br.) PADA TIKUS PUTIH JANTAN Jason Merari Peranginangin
Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.962 KB) | DOI: 10.31001/jfi.v6i1.12

Abstract

Mondokaki plant (Tabernaemontana divaricata, R.Br.) is a traditional medicine used in medicating high blood pressure, pharyngitis, conjunctivitis, mastitis, mad dog bite, antitusissive, anti-inflammatoty and sprain. The aim of the research was to know the anti-inflammatory effect of mondokaki leaves ethanolic extract on male shite rat. Mondokaki leaves were extracted using ethanol 70% by maceration method. The extract was tested to each group of the rat with doses of 3.75 mg/200 g bw, 7.5 mg/200 g bw, 15 mg/200 g bw. The negative control group was given CMC 0.5% solution and the positive control group was given sodium diclofenac as antiinflammatory agent. The compounds were all given orally one hour before the rat plantar was injected with carragenin 1% to make edema. The anti-inflammatory effect was observed from the ability to reduce edema volume at one hour interval for five hours. One way analysis of varian at 95% confidence was done to know the difference in each treatment and LSD test was done to know the difference between the treatment groups. The result of the research showed that ethanolic extract of 15 mg/200 g bw dose did not significantly different compared with the positive control. It was indicated that ethanolic extract of 15% mg/200 g bw dose had anti-inflammatory effect by reducing edema volume of male white rat in proportion with the positive control.
Pengaruh Ekstrak Etanolik Buah Takokak (Solanum torvum Swartz) terhadap Aktivitas Fagositosis pada Mencit Putih Jantan Balb/C dengan Metode Bersihan Karbon R. F. X. Premihadi Putra; Jason Merari Peranginangin; Reslely Harjanti
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (879.842 KB) | DOI: 10.31001/jfi.v11i1.51

Abstract

Solanum torvum Swartz (Solanaceae), known as takokak is a medicinal plant which has phagocytosis activity. Takokak plant usage with intent to suppress or reduce viral and bacterial intracellular infections, to improve immunodeficiency condition or as growth stimulant of body's immune cells in the immune system. This study was aimed to determine ability of takokak extract to increase the phagocytosis activity. This study used eight groups of white male mice each group six mice. Mice were given the test preparation once daily for seven days sequently. Group I: negative control 1% CMC-Na; group II: positive control dexamethasone 2 mg/kg bw mice; group III until VIII were given takokak ethanol extract dose of 37.5 mg/kg bw, 75 mg/kg bw, 150 mg/kg bw, 400 mg/kg bw, 500 mg/kg bw, 600 mg/kg bw respectively. Phagocytosis activity test data were analyzed using one way ANOVA test. The results showed that ethanol extract of takokak could increasing the phagocytosis activity and capacity of macrophages in Balb/c mice induced carbon clearance with carbon dose of 5 mg/kg bw.
Aktivitas Antiparkinson Ekstrak Rimpang Temulawak (Curcuma Xathorriza Roxb.) Pada Tikus Putih (Rattus Norvegicus) Galur Sprague Dawley Yang Diinduksi Haloperidol Nofika Dwi Anitasari; Jason Merari Peranginangin; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (858.208 KB) | DOI: 10.31001/jfi.v14i2.370

Abstract

Temulawak (Curcuma xathorriza Roxb.) Is a plant that contains curcumin. Curcumin in ethanol extracts of temulawak rhizome has been shown to penetrate the blood brain barrier and has a neuroprotective effect that can reduce the symptoms of parkinsonism caused by haloperidol. This study aims to determine the activity of ethanol extract of temulawak rhizome in reducing symptoms of Parkinson's and know the effective dose of temulawak rhizome extract in reducing symptoms of Parkinson's.This study used 35 rats divided into 7 groups, each group consisting of 5 rats. Group 1 was given aquadestilata. Group II was given a solution of 0.5% CMC-Na p.o. Group III was given levodopa dose 27 mg/kgbb. Group IV was given vitamin E dose of 180 IU/kgbb. Groups V, VI, VII were given the temulawak extracts of 120, 240 and 480 mg/kgbb. 45 minutes later all groups except group I were given haloperidol 2 mg/kgbb i.p. The catalepsy and rota rod tests were performed on days 0, 4, 7, 11 and 14.From catalepsy test of temulawak extract dose 120, 240, 480 mg/kgbb respectively showed activity of catalepsy decrease equal to 23,25; 52,28 and 58,56 %. While in rota rod test shows the activity increase time of latency consecutively equal to 26,87; 30,34 and 34,58 %. The effective dose of temulawak rhizome extract in reducing symptoms of Parkinson's is a dose of 240 mg / kgbb
Aktivitas Antiparkinson Ekstrak Gambir (Uncaria Gambir Roxb.) Pada Tikus Putih (Rattus Norvegicus) Galur Sprague Dawley yang Diinduksi Haloperidol Lutfi Nofitasari; Jason Merari Peranginangin; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.785 KB) | DOI: 10.31001/jfi.v14i2.373

Abstract

Parkinson disease is a disease that occurs due to damage to dopaminergic nerve cells in the brain which resulted in decreased dopamine production. Gambir is a dry extract made from the leaves of Uncaria gambier Roxb plant. Gambir contains flavonoids in the form of catechins not less than 90%, alkaloids and terpenoids. This study aims to determine the activity of gambir extract that can reduce the symptoms of Parkinson's in the male rats Sprague dawley induced haloperidol.Test animals of 35 rats divided into 7 groups. Group I (healthy control) was given aquadest orally, group II (negative control) was given a 0.5% CMC-Na solution, group III (positive control I) was given levodopa 27 mg / kgbb po, group IV (positive control II ) Were given vitamin E 180 IU / kgbb po Groups V, VI, and VII were given a dose of 70 consecutive gambir extracts; 140; 280 mg / kgbb. The whole group induced haloperidol 2 mg / kgbb i.p at the 45th minute after treatment except in the healthy group. Then the group was tested with a catalepsy bar test, recorded time latency expressed in scores and rota test rods, recorded time of latency in seconds on days 0, 4, 7, 11, and 14.The result of the research using catalepsy bar test method showed a decrease of catalepsy in gambir extract dose 70; 140; 280 mg / kgbb has a successive activity of 22.53; 52.50; 57.12%. While the results with rota rod test method showed% increase in time latency extract gambir respectively of 27.69; 35.75; 39.61%.
Efek Ekstrak Etanol Daun Kelor (Moringa oleifera, Lamk.) Pada Mencit Model Demensia: Kajian Memori Spasial, Kadar Malondialdehid Dan Jumlah Sel Piramidal Hipokampus Area CA1 Dan CA2-CA3 arikha ayu susilowati; Gunawan Pamudji Widodo; Jason Merari
Jurnal Farmasi Indonesia Vol 16 No 2 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (868.86 KB) | DOI: 10.31001/jfi.v16i2.612

Abstract

ABSTRACT Dementia is a disease of nerve cells in the brain, due to the hippocampus damaged by free radicals. EEDK (Ethanol extract of kelor leaves)(Moringa oleifera, Lamk.) contains phytochemicals, carotene, vitamins, minerals, amino acids, flavonoids and phenolics, proven to reduce oxidative damage and memory deficits. This study aims to determine the effect of EEDK on spatial memory, MDA levels, the number of hippocampal pyramidal cells damaged in the CA1, CA2-CA3 area and histopathological features of mice. The design of this study was pre-test and post-test control group design for spatial memory test and post test control group design for MDA levels, hippocampal pyramidal cell counts and histopathological features. This Reseach using 30 mice divided into of 6 groups, each group consist of 5 mice, namely the normal control group, positive control, negative control, EEDK group 100, 200, and 400 mg/kg body weight, all groups induced by Pb acetate 50 mg / KgBB except the normal group. Positive control was treated with quercetin 50 mg/kgBB, while negative controls were not treated. Memory test data obtained from the Morris water maze pre and post-test, antioxidant status data obtained from MDA levels and histopathological data obtained from the calculation of pyramidal cell counts. Data analysis used repeated measures ANOVA and ANOVA with Post Hoc LSD. The results showed that latency time, MDA level test and brain histopathology examination had significant differences between the negative control group and the EEDK group. EEDK 400 mg/kgBB was most effective in improving spatial memory, decreasing MDA levels, and preventing damage to the hippocampal pyramidal cell CA1, CA2-CA3 area.
Co-Authors Ahmad Nuzulul Abid Aljufri Mahmud Aminudin Ana Indrayati Andre Kurniawan Antoro, Sutopo Edy Argo Widianto arikha ayu susilowati Aryani, Norsarida Astuty, Meilinda Windy Atalia Tamo Ina Bulu Boedirahardja, Partana Chairun Darmawan, Nopandi Wisnu Desi Alviona Dewi Ekowati Dewi, Lucia Vita Inandha Dewi, Lucia VIta Inandha Dewi, Lutfiana Aswindra Diah Kartika Putri Dian Marlina Dwiannur, Febriandi Ramadhan Endang Diyah Ikasari Felix Imanuel Rachman Fitriarahmah, Giyan Gede Trima Yasa Gede Trima Yasa Gunawan Pamudji Widodo Harsono, Samuel Budi Ika Purwidyaningrum Ilham Kuncahyo Ismi Rahmawati Isna Jati Asiya Iswandi Iswandi Iyem Shahira Julia Megawati Djamal Keswara, Yane Dila Khofifah Maharani Lutfi Nofitasari Magdalena Retnoningsih Mardiyono Marlina, Dian Melviani Meyvie Belinda Kendage Mohammad Fauzy R. Syahruddin Muhamad Aulia Putra Tawakal Muhimmatul Khoiriyah Munawarah Munawarah Muslihatin, Muslihatin Mustika Endah Pratiwi Najmah Salsabila Narimo Nia Azzahra Nofika Dwi Anitasari Novitarini Novitarini Nur Anggreini Dwi Sasangka Oentari, Octaviana Dyah Onny Ziasti Fricilia Opstaria saptarini Prasojo Pribadi Prayitno, Krisdita Sundari Putri Pudiastuti RSP R.F.X Premihadi Putra Rahmawati, Ismi Reslely Harjanti Riskayanti Rizal Maarif Rukmana, Rizal Maarif Sabda Wahab Sarimanah, Jamilah Sawal, Rizky Ardian Hartanto Sholehah, Faza Putri Farihatus Sisca Latue Sofia, Anna Sri Rejeki Handayani Sudarwati, Vivid Latri Sulaiman, Teuku Nanda Saifullah Susanti, Kharisma Dewi Fadia Syamsul Ma'arif Titik Sunarni Titik Sunarni Tri Murti Andayani Tri Wijayanti Tri Wijayanti Widhoretno Puspandari Windi Antika Wiratantri, Fitra Indah Wiwin Herdwiani Wiwin Herdwiani Yaya Sulthon Aziz Yurita Werdiningsih Hutami