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santi dwi astuti
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Kajian Penggunaan Antihipertensi dan Potensi Interaksi Obat Pada Pengobatan Pasien Hipertensi Dengan Komplikasi santi dwi astuti; Elina Endang
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (873.102 KB) | DOI: 10.31001/jfi.v15i2.483

Abstract

ABSTRACT Hypertension is widely known as cardiovascular disease and is one of the risk factors for chronic renal failure. People with hypertension with kidney disorders occupy the highest incidence rate (35%) compared to hypertension which causes complications in other organs. CRF is a clinical condition characterized by irreversible decline in kidney function. Giving more than one antihypertensive drug can lead to drug interactions (Fitriani, 2007). Research Rahmawati et al. (2006) about a retrospective study of drug interactions in the education hospital of dr. Sardjito Yogyakarta reports that drug interactions that occur in hospitalized patients are 59%. Inpatients found 125 occurrences of drug interactions. The most common antihypertensive drug interactions are a combination of captopril and furosemide. The aim of this study is to describe the antihypertensive treatment in hypertensive patients with CDK along with the therapeutic relevance in terms of the right indication, the right patient, the right dose and the right drug based on JNC VIII. And other studies aim to examine the potential for drug interactions in antihypertensive therapy. The research method used is a type of descriptive research that is non-experimental, data taken retrospectively. The sample of this study were patients diagnosed with hypertension with complications who received combination antihypertensive therapy that met the inclusion and exclusion criteria. The results of the first study showed that the most widely used antihypertensive drugs by patients were loop diuretics, namely furosemide (9.23%). The category of drug accuracy according to JNC VIII was obtained for indication therapy (100%), right for the patient (100%), right for the drug (78.5%) for the right dose (98.46%). The results of the second study showed 31 patients (81.58%) had drug interactions and 7 patients (18.42%) did not experience drug interactions. Of the total 31 patients the potential for the most frequent interactions was moderate 120 (53.6%). The drug that is most used and causes interaction is catapres with diazepam causing moderate interactions Keywords: treatment studies, potential drug interactions, complications with hypertension
Analisis Pengelolaan Obat Di Instalasi Farmasi Puskesmas X Kabupaten Sukoharjo Amanta Rajendra Rafi Ramadani; Ika Purwidyaningrum; Santi Dwi Astuti
INSOLOGI: Jurnal Sains dan Teknologi Vol. 3 No. 4 (2024): Agustus 2024
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v3i4.4030

Abstract

The management of medicines in community health centers is a key element in healthcare services. This study aims to analyze the management of medicines at the Pharmacy Installation of X Community Health Center in Sukoharjo Regency. The aim of this research is to determine the suitability of indicators for the selection, planning, procurement, distribution, and use of drugs at this community health center, and to identify the strategic position of the pharmacy installation within the SWOT matrix. This research employs a descriptive analysis study design with a nonexperimental qualitative approach. Data were collected retrospectively through a review of documented records. Data collection techniques included document review, observation, and interviews at X Community Health Center in Sukoharjo Regency. The results showed that the indicators for compliance with the community health center's formulary were in accordance with standards, but the compliance of medicine items with the national formulary and the national essential medicines list was not up to standard. In the planning and procurement stages, all indicators met standards, such as the comparison between the number of medicine items planned and those actually used, the frequency of procurement of each medicine item annually, and planning deviations. In the distribution stage, the indicators for medicine matching with stock cards and the warehouse management system met standards. In the usage stage, the percentage of prescriptions with generic medicines met standards. The SWOT analysis results indicated a position in quadrant 1.
UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL BUAH CABE JAWA (Piper retrovactum Vahl) PADA MENCIT PUTIH JANTAN (Mus musculus L.) DENGAN METODE Forced Swimming Test (FST) Najiyyah, Trias Durrotun; Opstaria Saptarini; Santi Dwi Astuti
Jurnal Kefarmasian Akfarindo Vol 10 No 1 (2025)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1148

Abstract

Depresi merupakan gangguan kesehatan mental yang disebabkan karena turunnya kadar neurotransmiter di dalam otak. Buah cabe jawa (Piper retrovactum Vahl) memiliki kandungan senyawa utama alkaloid piperidine (piperin) yang dapat digunakan sebagai antidepresan. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antidepresan dan dosis efektif ekstrak etanol buah cabe jawa (Piper retrovactum Vahl). Penelitian ini menggunakan hewan uji yang terbagi dalam 5 kelompok. Terdapat 5 kelompok perlakuan, kontrol negatif Na CMC 0,5%; kontrol positif fluoxetine 1,3 mg/20gBB mencit; ekstrak etanol buah cabe jawa 200; 400; dan 800mg/20gBB mencit. Pengujian antidepresan menggunakan hewan uji mencit putih jantan (Mus musculus L.) dengan metode Forced Swimming Test. Buah cabe jawa sebagai bahan uji disoxhletasi menggunakan pelarut etanol 95%. Hewan uji diinduksi depresi dengan renang paksa 5 menit setiap hari selama 7 hari. Mencit setelah itu diberi perlakuan sampai hari ke-14. Parameter yang diamati adalah immobility time. Data hasil penelitian dianalisis menggunakan One way ANOVA. Hasil dari penelitian menunjukkan bahwa ekstrak etanol buah cabe jawa (Piper retrovactum Vahl) mempunyai aktivitas sebagai antidepresan yang dilihat dari penurunan immobolity time dengan metode forced swimming test. Dosis yang paling efektif untuk menurunkan waktu imobilitas secara signifikan yaitu dosis 400 mg/kg BB mencit dengan % penurunan immobility time sebesar 57,15%. Ekstrak etanol buah cabe jawa (Piper retrovactum Vahl) dengan dosis 200; 400; dan 800 mg/20gBB mencit mempunyai aktivitas sebagai antidperesan.
Co-Authors Amanta Rajendra Rafi Ramadani Elina Endang Ika Purwidyaningrum Najiyyah, Trias Durrotun Opstaria saptarini