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All Journal Jurnal Farmasi Indonesia Jurnal Kesmas dan Gizi (JKG)
AROFATUL HIDAYAH
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology Public Health

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Optimasi Pelarut Ekstraksi, Aktivitas Anthelmintika terhadap Ascaris lumbricoides Suis., dan Telaah Fitokimia Bunga Ekor Kucing (Acalypha hispida Burm. F.) MAMIK PONCO RAHAYU; ESTU SYA’BANA; AROFATUL HIDAYAH
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1025.473 KB) | DOI: 10.31001/jfi.v9i1.723

Abstract

Red hot cat's tail (Acalypha hispida Burm. F.) flowers is a traditional medicinal plant which can be used as an antelmintic. The aim of present study was to determine the solvent extraction of Red hot cat's tail flowers that produce the highest yield, to determine antelmintic activity against roundworms (Ascaris lumbricoides Suis.) and to determine the compounds in the extract. The powder was extracted by maceration with ethanol with four variations concentration. Extract was analyzed the soluble in ethanol extract concentration and the yield. The highest yield extract was tested on roundworms by in vitro. The worms were grouped into 12 groups randomly without regard to gender. The group consists of one negative control group was be given distilled water, the positive control group was be given piperazine citrate in 5 different concentrations, and the red hot cat's tail flowers group with 6 variations of concentration. Observation of the worm is done after 24 hours of treatment. Data were analyzed by probit method to determine the LC50. The results of this study were solvent extraction that produces the highest yield was 70% ethanol. The 70% ethanol extract had an antelmintic activity against roundworms with 6,61% w/v as LC50 values that equivalent to 0,12% w/v piperazine citrate. The 70% ethanol extract contained saponins, flavonoids, and tannins.
Evaluation Of Metformin Use in Type 2 Diabetes Mellitus Patients X Clinic Sei Karang Marbun, Romauli Anna; Siti Wahyuni; Arofatul Hidayah
JURNAL KESMAS DAN GIZI (JKG) Vol. 6 No. 2 (2024): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkg.v6i2.2037

Abstract

Diabetes mellitus is a disease or chronic metabolic disorder characterized by high blood sugar levels accompanied by impaired metabolism of carbohydrates, lipids and proteins as a result of insulin function insufficiency, which can be caused by impaired insulin production by the Langerhans beta cells of the pancreatic gland or caused by a lack of insulin. responsiveness of body cells to insulin. Type 2 DM is often found in around 90% of diabetes sufferers and usually occurs from the age of over 40 years in obese people. Metformin is the most frequently prescribed therapy for patients with type 2 diabetes mellitus. In addition, Metformin has a very good safety profile and is also pharmacoeconomically beneficial. The research was carried out by tracing the patient's past data from medical records obtained from the medical records unit at the X Sei Karang Clinic in the patient's medical records for 2022. Based on gender, it shows that of the 40 patients using oral anti-diabetic drugs in type II DM patients based on gender in 2022, the majority of genders are women (28 people) and the rest are men (12 people). Based on age, it shows that there are more people aged 34-60 years with a percentage of 67.5% compared to those aged 61-77 years with a percentage of 32.5%. Therapeutic use of oral antidiabetic drugs in outpatient type II DM patients at the X Sei Karang Clinic for the period October-December 2022 is Metformin with a 30% result with or without combination therapy. The accuracy of using oral anti-diabetic drugs in outpatients with type II DM at the X Sei Karang Clinic in 2022, found that the accuracy of using anti-diabetic therapy drugs at the appropriate dose was 83.33%.
Co-Authors ESTU SYA’BANA Mamik Ponco Rahayu Marbun, Romauli Anna Siti Wahyuni