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All Journal Mimbar Agribisnis: Jurnal Pemikiran Masyarakat Ilmiah Berwawasan Agribisnis Narra J
Artika Ramadhani
Mahasiswa program pendidikan S-1 Kedokteran Umum FK UNDIP
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Challenges in diagnosing and treating Liddle syndrome in resource-limited settings: A case report from Indonesia Prabowo, Nurhasan A.; Putranto, Wachid; Myrtha, Risalina; Ardyanto, Tonang D.; Gautama, Coana S.; Wulandari, Evi L.; Hermawati, Berty D.; Putri, Desy P.; Ramadhani, Artika; Dewi, Herlina K.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1000

Abstract

Liddle syndrome, a rare form of monogenic hypertension, poses significant diagnostic and therapeutic challenges due to its phenotypic variability and the need for genetic testing. The rarity of the condition, coupled with the limited availability of first-line treatments such as epithelial sodium channel (ENaC) blockers, makes this case report particularly urgent and novel, highlighting alternative management strategies in resource-limited settings. The aim of this case report was to present the diagnostic challenges, therapeutic strategies, and clinical outcomes of a patient with Liddle syndrome who did not have access to ENaC blockers, emphasizing the importance of early recognition and personalized treatment. A 35-year-old female presented with resistant hypertension (190/100 mmHg) and bilateral limb weakness. Laboratory results revealed persistent hypokalemia, hypernatremia, and metabolic alkalosis. Low aldosterone levels, alongside clinical and family history, led to the diagnosis of Liddle syndrome. Genetic testing was not conducted due to resource limitations, and ENaC blockers were unavailable. The patients were managed with a combination of alternative antihypertensive agents, potassium supplementation, and a low-sodium diet. Although this approach led to modest improvements in blood pressure and motor strength, persistent hypokalemia and hypernatremia underscored the suboptimal control of the syndrome's underlying pathophysiology in the absence of ENaC blockers. This case highlights the challenges faced in resource-limited settings and the need for innovative strategies to manage rare conditions like Liddle syndrome. Liddle syndrome's diagnostic and therapeutic challenges underscore the critical importance of early recognition and access to targeted therapies. In the absence of ENaC blockers, alternative treatment strategies can provide some benefit, but they often fall short of optimal management. This case emphasizes the need for enhanced clinical awareness, improved access to genetic testing, and the development of personalized treatment approaches to achieve better patient outcomes.
Rancangan Model Bisnis Pudidud (Puding Endud) Berbasis BMC Prayitno, Rizqi Apriliani; Zahra, Cut; Najwa, Chika Naili Ilmatun; Ramadhani, Levina; Azhara, Dhea Fahmi; Ardiastati, Arfika; Ramadhani, Artika; Setiawati, Indah
Mimbar Agribisnis : Jurnal Pemikiran Masyarakat Ilmiah Berwawasan Agribisnis Vol 12, No 1 (2026): Januari 2026
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ma.v12i1.19880

Abstract

Pudding is a popular dessert among various age groups. "Pudidud (Puding Endud)" is a healthy snack product featuring flavor innovation and unique packaging. This study aims to design the Pudidud business model using the Business Model Canvas (BMC) approach. A descriptive qualitative method with a case study was used on the Pudidud business in Bandung. Data were collected through observation, documentation, and in-depth interviews with the business owner and two staff members in production and marketing. The results show that Pudidud has high market potential by targeting teenagers and young adults with healthy lifestyles and strong social media engagement. Its strengths lie in using natural ingredients and eco-friendly packaging. This article presents a 9-block BMC structure and business development strategies based on a SWOT analysis.
Co-Authors Ardiastati, Arfika Azhara, Dhea Fahmi Dewi, Herlina K. Gautama, Coana S. Hermawati, Berty D. Indah Setiawati Myrtha, Risalina Najwa, Chika Naili Ilmatun Prabowo, Nurhasan A. Prayitno, Rizqi Apriliani Putranto, Wachid Putri, Desy P. Ramadhani, Levina Tonang Dwi Ardyanto Wulandari, Evi L. Zahra, Cut