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All Journal Majalah Kedokteran Bandung Majalah Obat Tradisional Medical Laboratory Technology Journal Indonesian Journal of Global Health research Narra J Jurnal Penyakit Dalam Indonesia Media Penelitian dan Pengembangan Kesehatan
Putranto, Wachid
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Pengaruh Faktor Risiko terhadap Waktu Timbulnya Efek Samping Kanamisin pada Tuberkulosis Resistan Obat Wati, Martha Ratna; Reviono, Reviono; Putranto, Wachid; Sutanto, Yusup Subagio; Harsini, Harsini
Majalah Kedokteran Bandung Vol 50, No 2 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.161 KB) | DOI: 10.15395/mkb.v50n2.1297

Abstract

Kanamisin adalah obat untuk terapi tuberkulosis resistan obat (TB RO) yang menimbulkan efek samping gangguan pendengaran, gangguan fungsi ginjal, dan gangguan elektrolit terutama hipokalemia. Penelitian bertujuan menilai kesintasan waktu timbulnya efek samping dan pengaruh faktor risiko usia, riwayat terapi streptomisin serta berat badan terhadap efek samping akibat pemberian kanamisin pasien TB RO. Penelitian kohort retrospektif dari data rekam medis pasien TB RO dari Januari 2011 sampai April 2017 di RSUD Dr. Moewardi Surakarta. Analisis pengaruh faktor risiko terhadap efek samping menggunakan uji cox regression. Dari 238 pasien didapatkan gangguan pendengaran 143 pasien, gangguan fungsi ginjal 147 pasien, dan hipokalemia 169 pasien. Usia lebih dari 40 tahun hazard ratio (HR) 2,419 (IK: 95%; 1,716–3,409; p= 0,000) dan jenis kelamin perempuan HR: 1,549 (IK: 95%; 1,089–2,202; p= 0,015) berisiko terjadi gangguan pendengaran. Usia lebih dari 40 tahun HR: 1,892 (IK: 95%; 1,353–2,646; p= 0,000) dan jenis kelamin perempuan HR: 1,667 (IK: 95%; 1,179–2,357; p= 0,004) berisiko terjadi gangguan fungsi ginjal. Riwayat streptomisin sebelumnya dan indeks massa tubuh (IMT) tidak berisiko timbul efek samping akibat pemberian kanamisin. Pengawasan ketat timbulnya efek samping gangguan pendengaran dan gangguan fungsi ginjal pasien usia lebih dari 40 tahun dan perempuan pada pengobatan TB RO.Kata kunci: Efek samping, gangguan fungsi ginjal, gangguan pendengaran, kanamisin, TB resistan obat Effects of Risk Factors on the Onset of Kanamycin’s Adverse Events in Drug Resistant TuberculosisKanamycin is a therapy for drug-resistant tuberculosis (TB) which may cause hearing loss, impaired kidney function, and electrolyte disorders, especially hypokalemia. The objective of this study was to assess patient survival and the effects of risk factors such as age, previous history of streptomycin therapy, and weight on adverse events due to kanamycin administration in patients with drug resistant TB. A retrospective cohort study was conducted in TB patients by using medical records from January 2011 to April 2017 in Dr. Moewardi Hospital Surakarta. Cox regression analysis was used to analyze the relation between risk factors and adverse events. Of 238 patients, 143 patients experienced hearing loss, 147 patients experienced impaired kidney function, and 169 patients had hypokalemia. Age over 40 and female gender had higher risks for hearing loss and impaired kidney function (HR: 2.419 (95% CI: 1.716–3.409; p= 0,000) and HR: 1,892 (95% CI: 1.353–2.646; p=0,000); HR: 1.549 (95%CI: 1.089–2.202; p=0,015), and HR: 1.667 (95% CI: 1.179–2.357; p=0.004)), respectively. History of streptomycin and body mass index (BMI) were not risk factors for  kanamycin’s adverse events. Therefore, closed monitoring on hearing loss and impaired kidney function is necessary for drug resistant TB patients aged over 40, and female patients. Key words: Adverse events, drug resistant tuberculosis, hearing loss, impaired kidney function, kanamycin
Relationship between Quality of Life and Nutritional Status on Chronic Kidney Disease Patients with Dialysis Type Dewi, Ratih Tri Kusuma; Putranto, Wachid; Susanto, Agung; Suseno, Aryo; Purwanto, Bambang; Mangesti, Rini Dwi; Giani, Maia Thalia; Septian, Muhammad Raditia
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Effect of Black Glutinous Rice Fermented Beverage on Short-Chain Fatty Acid Levels in Metabolic Syndrome Rats Nafisa, Putri Amalina; Nurwati, Ida; Putranto, Wachid
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86287

Abstract

Metabolic Syndrome (MetS) represents a combination of metabolic factors that can elevate the likelihood of developing type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). The high prevalence of MetS results in a significant socio-economic burden. However, current management approaches have limitations, prompting the exploration of functional foods and nutraceuticals as promising alternatives. The primary objective of this study is to investigate the impact of Black Glutinous Rice Fermented Beverage (BGRFB) on Short Chain Fatty Acids (SCFA) concentration in a MetS rat model. Rats were induced with a high-fat diet (HFD) and streptozotocin (STZ)-nicotinamide (NA) to induce MetS conditions. BGRFB was administered as a treatment to the MetS rat group. The results showed that the Negative Control (NC) group exhibited a significant decrease in SCFA levels compared to the normal group (N). However, administration of BGRFB to the T2 group resulted in a significant increase in SCFA levels. The SCFA levels in the T2 group were higher but not significantly different from the Positive Control (PC) group treated with metformin. Increasing SCFA production could be an effective strategy in addressing Mets. This study demonstrates the potential of BGRFB as a therapy to enhance SCFA production and improve MetS. The outcomes of this investigation are anticipated to provide insights into novel dietary approaches for MetS management.
Insertion/deletion (I/D) polymorphisms of angiotensin-converting enzyme gene and their implications for susceptibility and severity of COVID-19: A systematic review and meta-analysis Fajar, Jonny K.; Tamara, Fredo; Putranto, Wachid; Prabowo, Nurhasan A.; Harapan, Harapan
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.727

Abstract

The insertion or deletion polymorphisms of the angiotensin-converting enzyme gene (ACE I/D) have been the subject of significant research related to coronavirus disease 2019 (COVID-19). Despite this, the findings have remained uncertain and debatable. The aim of this study was to determine the associations between the ACE I/D polymorphisms and the susceptibility as well as the severity of COVID-19. A meta-analysis study (PROSPERO: CRD42022384562) was conducted by searching the articles published on PubMed, Scopus, and Embase as of May 15, 2023. Information regarding the impact of ACE I/D variant on the susceptibility to COVID-19 and its severity was collected and analyzed utilizing the Mantel-Haenszel method with a random effects model or fixed effects model, depending on the presence or absence of heterogeneity. Out of 3,335 articles, 21 articles were included, of which 13 investigated the association between ACE I/D and the risk of COVID-19 infection and 18 of them examined its influence on disease severity. The D allele of ACE increased risk of COVID-19 infection (OR: 1.41; 95%CI: 1.08–1.85; p-Egger: 0.0676; p-Heterogeneity: <0.001; p=0.0120), while ACE I allele (OR: 0.71; 95%CI: 0.54–0.93; p-Egger: 0.0676; p-Heterogeneity: <0.001; p=0.012) and II genotype (OR: 0.55; 95%CI: 0.34–0.87; p-Egger: 0.200; p-Heterogeneity: <0.001; p=0.011) decreased the risk of infection. Additionally, there was a notable association between the ACE ID genotype and an elevated likelihood of experiencing severe COVID-19 within the Asian population (OR: 1.46; 95%CI: 1.15–1.84; p-Egger: 0.092; p-Heterogeneity: 0.116; p=0.002). The presence of ACE I/D polymorphisms significantly influences the likelihood of being susceptible to and experiencing the severity of COVID-19.
Challenges in diagnosing and treating Liddle syndrome in resource-limited settings: A case report from Indonesia Prabowo, Nurhasan A.; Putranto, Wachid; Myrtha, Risalina; Ardyanto, Tonang D.; Gautama, Coana S.; Wulandari, Evi L.; Hermawati, Berty D.; Putri, Desy P.; Ramadhani, Artika; Dewi, Herlina K.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1000

Abstract

Liddle syndrome, a rare form of monogenic hypertension, poses significant diagnostic and therapeutic challenges due to its phenotypic variability and the need for genetic testing. The rarity of the condition, coupled with the limited availability of first-line treatments such as epithelial sodium channel (ENaC) blockers, makes this case report particularly urgent and novel, highlighting alternative management strategies in resource-limited settings. The aim of this case report was to present the diagnostic challenges, therapeutic strategies, and clinical outcomes of a patient with Liddle syndrome who did not have access to ENaC blockers, emphasizing the importance of early recognition and personalized treatment. A 35-year-old female presented with resistant hypertension (190/100 mmHg) and bilateral limb weakness. Laboratory results revealed persistent hypokalemia, hypernatremia, and metabolic alkalosis. Low aldosterone levels, alongside clinical and family history, led to the diagnosis of Liddle syndrome. Genetic testing was not conducted due to resource limitations, and ENaC blockers were unavailable. The patients were managed with a combination of alternative antihypertensive agents, potassium supplementation, and a low-sodium diet. Although this approach led to modest improvements in blood pressure and motor strength, persistent hypokalemia and hypernatremia underscored the suboptimal control of the syndrome's underlying pathophysiology in the absence of ENaC blockers. This case highlights the challenges faced in resource-limited settings and the need for innovative strategies to manage rare conditions like Liddle syndrome. Liddle syndrome's diagnostic and therapeutic challenges underscore the critical importance of early recognition and access to targeted therapies. In the absence of ENaC blockers, alternative treatment strategies can provide some benefit, but they often fall short of optimal management. This case emphasizes the need for enhanced clinical awareness, improved access to genetic testing, and the development of personalized treatment approaches to achieve better patient outcomes.
The Potential of Probiotics from West Sumatra, Indonesia on Low-Density Lipoprotein and Interleukin-6 Levels with Dyslipidemia Ridwan, Rhinie Uphita; Putranto, Wachid; Nuhriwangsa, Adi Magna Patriadi
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.618

Abstract

Dyslipidemia is a lipid metabolism disorder characterized by abnormal elevations or reductions in one or more lipid fractions within the plasma. This condition is a critical component of both metabolic syndrome and cardiovascular disease (CVD). This study aims to see the potential of curd administration on Low-Density Lipoprotein (LDL) and Interleukin-6 (IL-6) levels in dyslipidemia patients. This study is an experimental study with a pre-post test control group design consisting of a control group and a treatment group totaling 42 people taken randomly at the DR Drs M Hatta Bukittinggi Brain Hospital in June and July 2024. In the three groups, LDL and IL-6 examinations were carried out and measured before and after curd for 14 days. Treatment group 1 was given curd as much as 150 grams, treatment group 2 was given curd as much as 200 grams, given 1x a day, and the control group was not given curd. Data analysis was performed using the Wilcoxon statistical test and paired t-test. Results: There was no significant difference in LDL (p=0.360) and IL-6 (p=0.932) levels after giving curd for 14 days. However, there was a decrease in LDL and IL-6 levels after giving curd for 14 days. Conclusion: The results showed that giving curd for 14 days in the treatment group 1 (150gram) and treatment 2 (200gram) can reduce LDL and IL-6 levels. Consuming probiotics for 14 days can reduce LDL and IL-6 levels.
EFFECT OF BLACK GLUTINOUS TAPE BEVERAGE ON MALONDIALDEHYDE IN METABOLIC SYNDROME RATS Khoirunnisa, Rahmi; Putranto, Wachid; Nurwati, Ida
Media Penelitian dan Pengembangan Kesehatan Vol. 33 No. 4 (2023): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v33i4.1719

Abstract

Sindrom Metabolik (SM) dikenal sebagai sindrom resistensi insulin, juga dikenal sebagai faktor risiko DMT2. Diperlukan kombinasi perubahan gaya hidup dan pengobatan dalam penanganan SM. Sari tape ketan hitam (BGTB) sebagai pangan lokal mengandung tinggi kandungan antosianin sebagai sumber antioksidan dan Lactobacillus spp., yang berpotensi sebagai sumber probiotik yang dapat memperbaiki stres oksidatif pada pasien SM. Studi ini dirancang untuk mengevaluasi efek BGTB dalam menangani stres oksidatif, dengan melakukan pengukuran pada kadar MDA. Sebanyak 30 tikus Sprague Dawley digunakan dalam penelitian ini dan mereka dibagi menjadi lima kelompok. Kelompok normal (KN) akan diberikan diet standar, sedangkan keempat kelompok akan diberikan high-fat diet (HFD) selama 2 minggu dan kemudian diinduksi menggunakan Streptozotocin (STZ) dan Nicotinamide (NA); kontrol negatif (KN) akan diberikan standar diet; kontrol positif (KP) akan diberikan metformin 9 mg; kelompok perlakuan 1 (P1) dan perlakuan 2 (P2) akan diberikan BGTB sebanyak 0,9 ml 200 gr-1 BB dan 1,8 ml 200 gr-1 BB, diberikan selama 28 hari. Hasil menunjukan adanya perbedaan sginifikan (p=0.000) pada kadar malondialdehid, dengan perbandingan tertinggi pada kelompok P2. Penelitian ini menunjukkan BGTB dapat menjadi makanan fungsional dan berpotensi menjadi sumber probiotik untuk pasien SM.
The Potential of Asian Swamp Eel (Monopterus Albus) as A Functional Food for Anemia: A Scoping Review Sulastri, Iis; Putranto, Wachid; Wijayanti, Lilik
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.5986

Abstract

Anemia remains a significant global health issue. One of the causes is the inadequate of protein and iron intake. So that, erythropoiesis in body less than optimal. Asian swamp eel (Monopterus albus) can potentially be a functional food that can be included food products because it is rich in nutriens that have a potential impact on anemia. Objective: This scoping review aim was to explores the nutritional composition of Asian swamp eel and its effects on anemia, focusing on mechanisms by which its nutrients influence anemia biomarkers. Methods: This scoping review was performed using the 5-step Arkeys and O’Malelev framework and reported according to PRISMA ScR. Two electronic databases were searched systematically. Article are included if eligible. Results: The result was descriptive and qualitative analyses. A total of 1,245 articles were collected. Key findings suggest that the high protein and vitamin content in eel can significantly improve hemoglobin levels and other anemia indicators. Conclusions: This review highlights the potential of incorporating eel into dietary interventions as a sustainable and effective approach to mitigating anemia prevalence.
Co-Authors Artika Ramadhani Bambang Purwanto Dewi, Herlina K. Fredo Tamara, Fredo Gautama, Coana S. Giani, Maia Thalia Harapan Harapan Hermawati, Berty D. Ida Nurwati Jonny K. Fajar Khoirunnisa, Rahmi Lilik Wijayanti Mangesti, Rini Dwi Mochammad Imron Awalludin Myrtha, Risalina Nafisa, Putri Amalina Nuhriwangsa, Adi Magna Patriadi Prabowo, Nurhasan A. Putri, Desy P. Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Reviono Reviono Ridwan, Rhinie Uphita Septian, Muhammad Raditia Sulastri, Iis Susanto, Agung Suseno, Aryo Tonang Dwi Ardyanto Wati, Martha Ratna Wulandari, Evi L. Yusup Subagio Sutanto