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All Journal Molekul: Jurnal Ilmiah Kimia
Hersa Milawati
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Caryophyllene-Type Sesquiterpenoids from the Stembark of Aglalia harmsiana and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells Hersa Milawati; Desi Harneti; Rani Maharani; Nurlelasari Nurlelasari; Ace Tatang Hidayat; Mohamad Nurul Azmi; Yoshihito Shiono; Unang Supratman
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (367.192 KB) | DOI: 10.20884/1.jm.2019.14.2.543

Abstract

Sesquiterpenoid is a class of terpenoid compounds that have the most abundant diversity of structures and biological activitiesthat can be found in natural resources. Tropical plants are main source of sesquiterpenoid compounds such as Aglaiagenus belong to Meliaceae family. A. harmsianais a species from Aglaiathat only has few previous researchs.  Therefore, the purpose of this study was to isolate and determine the structure of sesquiterpenoid compounds from stem barkA. harmsianaalong withtheir cytotoxic activity against MCF-7 breast cancer cells. The isolation process begins by extracting powder from A. harmsianastembark using n-hexane, ethyl acetate and methanol. All extracts were evaluated for their cytotoxic activity against MCF-7 breast cancer cells, and n-hexane extractsshowed significant cytotoxic activitywith IC50values of 117.86 µg/mL. Therefore, n-hexane extracts were further separated and purified by various chromatographic techniquesto obtain compounds 1and 2. Compounds 1and 2were elucidated their chemical structures by spectroscopic methods includingIR, NMR, and MS as well as bycomparison of data with literatures and identified ascaryophyllene-typesesquiterpenoids, β-caryophylleneoxide (1) and senecrassidiol (2). Compounds 1and 2were submitted for cytotoxic eveluation on MCF-7 breast cancer cells and as a result, β-caryophyllene oxide (1) showed the stronger activity compared to senecrassidiol (2). These finding indicatedthat the cytotoxic activity of caryophyllene-typesesquiterpenoid areinfluenced by the presence of double bonds and configuration of methyl groups.
Sesquiterpenoid Compounds from The Stembark of Aglaia minahassae (Meliaceae) Nunung Kurniasih; Hersa Milawati; Mohamad Fajar; Ace Tatang Hidayat; Rizky Abdulah; Desi Harneti; Unang Supratman; Mohamad Nurul Azmi
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.996 KB) | DOI: 10.20884/1.jm.2018.13.1.410

Abstract

Two sesquiterpenoid compounds, 4(15)-eudesmen-1b,6a-diol (1) and spathulenol (2) have been isolated from the stembark of Aglaia minahassae belong to Meliaceae family. The chemical structures of 1 and 2 were identified on the basis of spectroscopic evidence including UV, IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. This compounds were isolated from this plant for the first time.
Co-Authors Ace Tatang Hidayat Desi Harneti Putri Huspa Mohamad Fajar Mohamad Nurul Azmi Mohamad Nurul Azmi Nunung Kurniasih Nurlelasari Nurlelasari Rani Maharani Rizky Abdulah Unang Supratman Yoshihito Shiono