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All Journal Molekul: Jurnal Ilmiah Kimia
Santi Nur Handayani
Jurusan Kimia, Program Sarjana MIPA Unsoed Purwokerto
Chemical Engineering, Chemistry & Bioengineering Chemistry

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SINTESIS DAN UJI AKTIVITAS ANALGETIKA-ANTIINFLAMASI SENYAWA N-(4t-butilbenzoil)-p-aminofenol Sri Sutji Susilowati; Santi Nur Handayani
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.277 KB) | DOI: 10.20884/1.jm.2006.1.1.21

Abstract

The synthesis of N-4t-butyl benzoil-p-aminophenol has been done by reacting p-aminophenol and N-4t-butyl benzoil chloride compounds, then the products were isolated and analyzed by TLC, melting point determination, UV/Vis Spectrofotometry, infra red spectrofotometry and mass spectrometry. The synthesis yield of N-4t-butylbenzoil-p-aminophenol was 33,52%, with the compound melting point between 192-194 oCThe determination of analgesic (ED50 of % analgesic activity ) and anti inflammatory activity (ED50 of edema inhibition) gave the ED50 of % analgesic activity was 144 mg/kg and ED50 of % edema inhibition was 43,24 mg/kg.
Co-Authors Sri Sutji Susilowati