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All Journal Acta Interna : The Journal of Internal Medicine
Bambang Sigit Riyanto
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Health Professions Medicine & Pharmacology

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LEVEL OF INTERLEUKIN-6 IN OBESE PEOPLE WITH AND WITHOUT INSULIN RESISTANCE Safitri, Nedya; Riyanto, Bambang Sigit; Asdie, H. Ahmad Husain
Acta Interna The Journal of Internal Medicine Vol 1, No 1 (2011): Acta Interna The Journal of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

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Abstract

ABSTRACTBackground. Obesity is one of the risk factor for type 2 diabetes mellitus characterized by insulin resistance, decrease insulin secretion and hyperglycemia. Chronic inflammation has been proposed to have an important role in the pathogenesis of obesity related insulin resistance. A number of studies have indicated that several humoral markers of inflammation are elevated in people with obesity and type 2 diabetes mellitus, because adipose tissue secretes a number of proinflammatory cytokines, including interleukin-6. The level of plasma IL-6 is increase in obese people.Objective. To investigate the mean of difference in the level of IL-6 in obese people with and without insulin resistance.Subjects and Method. The study design was cross-sectional. It was conducted in obese people with BMI ≥ 25 kg/m2. Insulin resistance were measured with HOMA-IR methode, calculated using the following formula: fasting serum glucose X fasting plasma insulin/22,5. Insulin resistance was defined when HOMA-IR > 2,77. Interlukin-6 was measured with Quantikine High Sensitivity human IL-6 ELISA. Difference of mean of IL-6 level was analyzed by student’s t-test for normal distribution and Mann- Whitney U-test if distribution was not normal.Results. There were 56 subjects, 24 (42,9%) subjects with insulin resistance and 32 (57,1%) subjects without insulin resistance. Obese people with insulin resistance had higher mean level of IL-6 than obese people without insulin resistance, although the difference was not significant (20,05±8,59 vs 18,98±8,15 pg/ml; p=0,639; 95% CI -5,58-3,46).Conclusion. There was no difference in the mean of IL-6 level in obese people with and without insulin resistance. Keywords. IL-6, obese, insulin resistance 
LEVEL OF INTERLEUKIN-6 IN OBESE PEOPLE WITH AND WITHOUT INSULIN RESISTANCE Nedya Safitri; Bambang Sigit Riyanto; H. Ahmad Husain Asdie
Acta Interna The Journal of Internal Medicine Vol 1, No 1 (2011): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4381.112 KB) | DOI: 10.22146/acta interna.3861

Abstract

ABSTRACTBackground. Obesity is one of the risk factor for type 2 diabetes mellitus characterized by insulin resistance, decrease insulin secretion and hyperglycemia. Chronic inflammation has been proposed to have an important role in the pathogenesis of obesity related insulin resistance. A number of studies have indicated that several humoral markers of inflammation are elevated in people with obesity and type 2 diabetes mellitus, because adipose tissue secretes a number of proinflammatory cytokines, including interleukin-6. The level of plasma IL-6 is increase in obese people.Objective. To investigate the mean of difference in the level of IL-6 in obese people with and without insulin resistance.Subjects and Method. The study design was cross-sectional. It was conducted in obese people with BMI ≥ 25 kg/m2. Insulin resistance were measured with HOMA-IR methode, calculated using the following formula: fasting serum glucose X fasting plasma insulin/22,5. Insulin resistance was defined when HOMA-IR > 2,77. Interlukin-6 was measured with Quantikine High Sensitivity human IL-6 ELISA. Difference of mean of IL-6 level was analyzed by student’s t-test for normal distribution and Mann- Whitney U-test if distribution was not normal.Results. There were 56 subjects, 24 (42,9%) subjects with insulin resistance and 32 (57,1%) subjects without insulin resistance. Obese people with insulin resistance had higher mean level of IL-6 than obese people without insulin resistance, although the difference was not significant (20,05±8,59 vs 18,98±8,15 pg/ml; p=0,639; 95% CI -5,58-3,46).Conclusion. There was no difference in the mean of IL-6 level in obese people with and without insulin resistance. Keywords. IL-6, obese, insulin resistance 
Effect of Pursed-Lips Breathing on Quality-of-Life Chronic Obstructive Pulmonary Disease Patients with The Short Form-36 (SF-36) Widiatmoko, Widiatmoko; Riyanto, Bambang Sigit; Retnowulan, Heni
Acta Interna The Journal of Internal Medicine Vol 12, No 2 (2023): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.98239

Abstract

Background. Chronic obstructive pulmonary disease (COPD) is a disease of high prevalence that is characterized by irreversible airway obstruction. The most frequent symptoms such as tightness during activity and fatigue have a negative impact on the quality of life of patients and limit physical activity in everyday life. One of the goals of COPD therapy is to improve the quality of life of patients. Pursed-Lips Breathing (PLB) as one of the pulmonary rehabilitation options is known to improve breathing patterns, increase tidal volume, and reduce shortness of breath.Objective. To demonstrate the influence of PLB on the quality of life of COPD patients as measured by The Short-Form 36 questionnaire.Methods. A prospective, single-blind, randomized controlled trial study was conducted at RSKP Paru Respira, Bantul, Yogyakarta. The subjects of the study were stable COPD patients who met the inclusion and exclusion criteria. The SF-36 score was assessed in both groups before and after 28 days (4 weeks). The independent variable PLB treatment and the dependent variable SF-36 score were measured before and after treatment. Statistical analysis was carried out by a mean difference test between the treatment group and the control group.Results. Seventy-eight patients (mean age, 63 years) were randomized into the treatment group (n=41 patients) continuing standard therapy and doing 8-minute PLB for 28 days and the control group (n=37 patients) only continuing the previous standard therapy. The PLB treatment group showed an increase in the mean delta of the SF-36 score which was especially significant in aspects of physical function, physical role, and social function. There was a significant difference in the increase of average total SF-36 score in the PLB treatment (8.93 ± 15.85) compared to the control group (2.09 ± 8.15) of the 100 points total score (p=0.033).Conclusion. There was an improvement in the SF-36 score in COPD patients who received standard therapy and pulmonary rehabilitation with a PLB technique for four weeks.
Co-Authors Djoko Wahyono H. Ahmad Husain Asdie Ika Puspitasari Nanang Munif Yasin Nedya Safitri Retnowulan, Heni Widiatmoko, Widiatmoko