Garuda - Garba Rujukan Digital

Relationship between the Degrees of Severity Sequelae after Treatment with Quality of Life in Patients of Pulmonary Tuberculosis Patients Deddy Nur Wachid Achadiono; Heni Retnowulan; Tiara Putri Utami
Acta Interna The Journal of Internal Medicine Vol 6, No 1 (2016): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

ABSTRACTBackground: Tuberculosis remains a global health problem, especially for developing countries.Tuberculosis can cause permanent deformity of the lung parenchyma, airways, pleura, mediastinum,chest wall, and vascular. This deformity is residual symptoms or sequelae. Tuberculosis sequelae mayoccur in most patients although has completed treatment. These sequelae can affect lung functionand will ultimately influence patient’s quality of life.Objective: This study aims to determine the relationship between the severities of sequelae aftertuberculosis based index Willcox with patient’s quality of life.Methods: The study design was cross-sectional at patients of outpatient clinic BP4Yogyakarta from September 2013 until the samples are met. The relationship between theseverities of the degree of sequelae after treatment with the quality of life in patients with pulmonarytuberculosis will be analyzed using t test. Relationship is significant if p <0.05 with 95% confidenceintervals.Results: The total of the subjects are 37 consist of 24 patients (64.9%) males and 13 (35.1%) women.Subjects who met the criteria will be examined the thoracic x-ray poster anterior (PA). Severity of tuberculosis sequelae will be assessed according to the index Willcox. Subjects also completed a SGRQ questionnaire as a tool for assessing their quality of life. There is a significant correlationbetween the severity of tuberculosis sequelae with the quality of life in the activity (ρ = 0.031) and total (ρ = 0.037) domain.Conclusions: There is a relationship between the severities of the quality of life in patients with pulmonary tuberculosis sequelae.

The Relationship between 12MWD and Quality of Life in Tuberculosis Sequelae Patients Heni Retnowulan; Deddy Nur Wachid Achadiono; Andika Ilham Rahmatullah
Acta Interna The Journal of Internal Medicine Vol 6, No 1 (2016): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Background: The incidence of TB cases in Indonesia is very high. Although it was undergoing treatment and was declared cured the infection, but it does not mean that the infection does not leave sequelae.Patients TB sequelae decreased functional capacity and quality of life.Aim: The purpose of this study is to determine the relationship between functional capacity (12MWD) and quality of life (SGRQ) in tuberculosis sequelae patients.Method: Patients with TB sequelae aged 18-59 years without comorbid examined functional capacity with a 12-minute walking distance test and assessment of quality of life using the SGRQ questionnaires. Statistical analysis is using correlation and regression.Result: There were significant negative correlation (p<0.05) between the 12 minute walking distance and activity domain (r -.336). In other domains, there is a negative relationship but not significant at the totaldomain (r -.152), impacts (-.124), and symptoms (-.043).Conclusion: There is a significant negative relationship between the 12 minute walking distance and quality of life as assessed by questionnaire SGRQ in activity domain, in other domains there is also a negative correlation but was not statistically significant. The higher of functional capacity patients with tuberculosis sequelae, the quality of life also become higher.

The relationship between six minutes walking distance and quality of life in pulmonary tuberculosis sequelae patients Heni Retnowulan; Deddy Nur Wachid Achadiono; Anggraeni Ayu Rengganis
Acta Interna The Journal of Internal Medicine Vol 6, No 2 (2016): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

ABSTRACTBackground: Tuberculosis is an infectious disease that affects the lung and has high incidence. It could leave sequelae in the patient that has been declared cured. Tuberculosis sequelae results in changes of lung function that could lead to deteriorating of functional capacity and quality of life.Aim: The study aim to determine the relationship between functional capacity (6MWD) and quality of life (SGRQ) within pulmonary tuberculosis sequelae patients.Method: This study used cross sectional design and performed on pulmonary tuberculosis sequelae patient in pulmonary clinic of Dr. Sardjito General Hospital and BP4 Yogyakarta. Functional capacity was assessed with six minutes walking distance and assessment of quality of life using SGRQ questionnaire. Distribution of data was tested using the Shapiro-Wilk statistical test. Spearman correlation test and regression test was used to analyze the correlation between 6-minute walking distance test and assessment of quality of life using the SGRQ questionnaire.Result: The 6 minutes walking distance was 257.02±64.56 m. There were significant negative correlation between 6 minutes walking distance and SGRQ score activity domain (r=-.333, p<0.05). The others domains in SGRQ, there were no significant negative correlation at domain symptoms (r-.062), impacts (-.114), and total (-.135).Conclusion: There were negative correlation between the 6 minutes walking distance (6MWD) and SGRQ score. There was significant negative correlation between 6 minutes walking distance (6MWD) and activity domain in the SGRQ score.Keywords: tuberculosis sequelae, functional capacity, 6MWD, quality of life, SGRQ.

Relationship between Degrees of Dyspnea with Functional Capacity in Pulmonary Tuberculosis Sequelae Patients Deddy Nur Wachid Achadiono; Heni Retnowulan; Eko Nugroho
Acta Interna The Journal of Internal Medicine Vol 6, No 2 (2016): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

ABSTRACT Background: TB disease is still a serious health problem. Due to the changes that occur because of TB infection, appears sequelae in patients with pulmonary tuberculosis. TB sequelae will have an impact on the patient’s life, especially to do with the degree of dyspnea and functional capacity.Objective: To know the relationship between degree of dyspnea with functional capacity in pulmonary tuberculosis sequelae patients.Method: The design of this study is cross-sectional observational study. Subjects were patients with TB who have had at least 6 months of therapy that has been declared cured by leaving sequelae in Dr. Sardjito Hospital and BP4 Yogyakarta in September 2013. The sample was selected based on the selection criteria. Statistical analysis is using One-Way ANOVA.Results: From the 42 patients, there were 78.6% of patients with MRC scale 0, 11.9% of patients with MRC scale 1, and 4.8% respectively of patients with MRC scale 2 and 3. The mean of 6-minute walk test distance is 257.02±64.56 meters. There is a significant relationship on comparison of the mean of 6-minute walk test distance on each MRC scale (p = 0.028).Conclusion: There is a relationship between degrees of dyspnea with functional capacity in pulmonary tuberculosis sequelae patients. Keywords: tuberculosis sequelae, degrees of dyspnea, functional capacity

Infl uence of Pursed-Lips Breathing to Improve Quality of Life in Chronic Obstructive Pulmonary Disease Patients Meldy Muzada Elfa; Eko Budiono; Heni Retnowulan
Acta Interna The Journal of Internal Medicine Vol 9, No 1 (2019): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Background. Worsening of Chronic Obstructive Pulmonary Disease (COPD) may decrease the quality of life of patients. Rehabilitation of patients with COPD may increase exercise tolerance and improve quality of life. Pursed-Lips Breathing (PLB) activates abdominal muscles during expiration for improving gas exchange and oxygen saturation in the arteries, increasing the tidal volume and reduce shortness of breath, anxiety, and tension thus improving the quality of life. St George's Respiratory Questionnaire (SGRQ) was a tool to measure the quality of life of patients with COPD, which has been validated. Patients with improved quality of life were characterized by a decrease in the SGRQ score after PLB training.Aims. Analyze the effect of improved quality of life in patients with stable COPD using PLB + standard therapy compared to standard therapy only.Methods. This research used an open-label Randomized Controlled Trial (RCT) design and conducted in patients with COPD stages 2 and 3. It was performed in Rumah Sakit Khusus Paru (RSKP) Respira Bantul, Yogyakarta. The study group was composed of 47 subjects, who continued the previous standard therapyand performed PLB 8 minutes once a day for 28 days. The placebo group (44 samples) continued the previous standard therapy alone. Measuring the quality of life using the SGRQ performed in both groupsbefore and after the experiment. Statistical analysis included independent t-test and Mann Whitney U-test.Results. Th ere were improvements in the quality of life that clinically characterized by a decrease in SGRQ total score of 12.19 points out of 100 points total in the PLB group. Th ere was a very significant difference in the decline in total SGRQ score between the study group and placebo groups (p <0.001).Conclusion. Pursed-Lips Breathing (PLB) improves the quality of life of patients with stable COPD was characterized by a decrease in SGRQ of 12.19 points out of 100 points total.Keywords. COPD (Chronic Obstructive Pulmonary Disease), PLB (Pursed-Lips Breathing), SGRQ (St George’s Respiratory Questionnaire), quality of life

PERBEDAAN KEPATUHAN PENGGUNAAN OBAT ASMA INHALASI TERHADAP KUALITAS HIDUP PASIEN ASMA Qurrata A'yun; Zullies Ikawati; Heni Retnowulan
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 4, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.294

Tidak semua pasien asma patuh pada rejimen terapiTujuan dari penelitian ini untuk mengetahui apakah pasien asma yang kurang patuh memiliki skor kualitas hidup 0,5 poin lebih rendah dibandingkan dengan pasien yang lebih patuh pada penggunaan obat asma inhalasi dan faktor-faktor apa sajakah selain kepatuhan yang dapat mempengaruhi kualitas hidup. Penelitian dilakukan dengan studi potong lintang menggunakan data survei pasien asma dewasa di Poliklinik Paru RSUP Dr. Sardjito dan Poliklinik Penyakit Dalam RSUD Sleman Yogyakarta. Kepatuhan merupakan variabel independen yang diukur menggunakan Medication Adherence Rating Scale for Asthma (MARS-A-10) dengan Visual Analogue Scale sebagai respon jawaban untuk tiap aitem. Skor kepatuhan berkisar 0-900 dengan titik potong <810 dinyatakan sebagai kurang patuh. Metode stepwise digunakan untuk mengeluarkan variabel- variabel dengan nilai p kurang dari 0,5. Subyek penelitian, rerata lama menggunakan obat asma inhalasi 9,09±6,51 tahun (mean±SD). Rerata skor kepatuhan 600,99±173,40, dengan 84,9% termasuk dalam kelompok kurang patuh (skor<810). Perbedaan rata-rata skor total AQLQ antara pasien yang patuh dan yang kurang patuh sebesar 0,67 poin. Dari model analisis multivariat yang terdiri dari kepatuhan sebagai variabel independen dan 3 variabel perancu (riwayat masuk UGD, tingkat kontrol asma dan lama menggunakan obat asma inhalasi), diperoleh R2 sebesar 0,445. Kualitas hidup yang lebih baik berkaitan erat dengan kontrol asma yang lebih baik, menurunnya angka kejadian rawat di UGD, lamanya menggunakan obat asma inhalasi dan tingginya skor kepatuhan pasien. Pasien asma yang kurang patuh (skor MARS-A-10 810) memiliki skor kualitas hidup (AQLQ) 0,67 poin lebih rendah dibandingkan dengan pasien asma yang lebih patuh (skor MARS-A-10 ≥810) pada penggunaan obat asma inhalasi. Kata kunci: kepatuhan, asma, MARS-A-10, obat asma inhalasi

Ketahanan hidup 2 tahun pasien tuberkulosis resisten obat di RS. Moewardi Surakarta tahun 2010-2014 Artika Fristi Firnawati; Riris Andono Ahmad; Heni Retnowulan
Berita Kedokteran Masyarakat (BKM) Vol 33, No 8 (2017)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Two year survival of drug resistant tuberculosis patients in Moewardi hospital in Surakarta in 2010-2014PurposeThe purpose of this study was to determine the two year survival rate and predictor factors of mortality in drug resistant tuberculosis patients during treatment at the Moewardi Hospital in Surakarta.MethodsThis research was a retrospective cohort study of 250 drug resistant tuberculosis patients receiving treatment in the Moewardi Hospital in January 2011-September 2014. Data were analyzed using survival analysis to find factors affecting the 2 year survival. Our variables were demographic factors, disease characteristics and treatment history. We used Cox regression test with 5% significance level.Results2-year survival rates of drug resistant patients was 74.82%. age, the type of patient, HIV status, side effects of medications and culture conversion were significant to survival rate in bivariate analysis. Cox regression test showed that aged ≥ 40 years (HR 3.221; 95% CI 1.037 to 10.001) and have HIV-positive status (HR 18.086; 95% CI 1.958 to 167.073) were related with reduction of two year survival rate in drug resistant tuberculosis patient. ConclusionAge above 40 years old and HIV positive status for drug-resistant tuberculosis patients may accelerate their death. The screening of HIV in drug resistant tuberculosis patients is needed in order to increase two year survival rate of patients during treatment.

Comparison of Red Cell Distribution Width Values towardsMortality in Adult and Elderly Hospital-Acquired PneumoniaPatients in Dr. Sardjito Hospital Sari, Desty Gusti; Asdie, Rizka Humardewayanti; Retnowulan, Heni
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Introduction. Hospital-acquired pneumonia (HAP) is a major cause of morbidity and mortality. Red cell distribution width (RDW) is associated with mortality in patients with septic shock and community-acquired pneumonia (CAP). However, little is known about the effect of elevation of RDW value on mortality in HAP patients, especially in the elderly population who have a worse prognosis. This study aimed to determine the proportion of adult and elderly HAP patients who have an increase in RDW value and the relation between the increase in RDW value to the risk of mortality in HAP patients during hospitalization. Methods. A cross-sectional and retrospective cohort study was performed using medical records of inpatients diagnosed with HAP in RSUP Dr. Sardjito Yogyakarta from March 2014 until March 2015. The study’s sample was chosen by a consecutive sampling method. The data were analyzed with chi-square and logistic regression. Results. During the study period, a total of 106 patients were diagnosed with HAP with fulfilled the inclusion and exclusion criteria. Sixty-eight subjects (64.15%) survived, and 38 subjects (35.84%) died. The median RDW value was 15.3% (range 11.4 – 29.8%). The proportion of adult and elderly HAP patients toward the increase in RDW value was not statistically significant (p=0.331). Factor contributing to the increase of RDW value was haemoglobin (p<0.001; RR 5.617 (95% CI 2.294 – 13.756) and thrombocyte (p=0.002; RR 4.471 (95% CI 1.720 – 11.625). There was a proportion difference between RDW value and HAP mortality (p=0.043), but it was not statistically significant. Factor contributing to the increase of HAP mortality was sepsis (p<0.001; RR 7.121 (95% CI 2.599-19.509)) and leucocyte (p=0.031; RR=3.077 (95% CI 1.108 – 8.546)). Conclusions. There is no proportion difference in increasing RDW value between adult and elderly HAP patients. We also found that RDW value was not contributing to make the increase in mortality among HAP patients. However, this study found other factors, including haemoglobin and platelet level which correlated with the increase of RDW. We also found that sepsis and high leukocyte levels are significantly correlated with the incidence of mortality among HAP patients.

Anti-Tuberculosis Therapy after DRESS: Case Report Wahyuni, Dwi; Mulya, Deshinta Putri; Retnowulan, Heni
Acta Interna The Journal of Internal Medicine Vol 11, No 1 (2021): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.94635

Introduction.Anti-tuberculosis-induced DRESS (drug reaction with eosinophilia and systemic symptoms) is uncommon, and usually delayed in diagnosis. The patient has minor complain and the clinical presentation involves the side effect on their heart and skin. Antituberculosis-related DRESS may have been present, but it has been underdiagnosed and underreported for several years. Management including discontinuation of the suspected drugs and changing it with second line treatment become less effective. Identifying the causative drug in DRESS is very difficult, especially in antituberculosis drugs.Case. A 34-year-old woman complains of having itch and redness throughout the body and fever. Two months before hospitalization, the patient was diagnosed with tuberculosis based on GeneXpert examination. Patients were given anti-tuberculosis drug therapy (OAT) which was 4 fixed drug combinations (FDC). Two weeks after taking the drugs, complains appeared. After 3 weeks the drug was stopped and in the next 1 week the patient's condition got worse, with itching and redness of the whole body accompanied by fever. Patients received treatment for 13 days with 125 mg/24-hour methylprednisolone therapy gradually reduced with OAT therapy levofloxacin 500 mg/24 hours and streptomycin 1 gram/24-hour IM (intramuscular).Conclusion. DRESS triggered by OAT was very rare and underreported. The choice of therapy after DRESS needed to be well considered, because it increased the risk for a DRESS to return with more severe manifestations when re-administering the same drug. The management in tuberculosis patients with a history of DRESS was given with second-line OAT with treatment options based on the clinician's experience.

Effect of Pursed-Lips Breathing on Quality-of-Life Chronic Obstructive Pulmonary Disease Patients with The Short Form-36 (SF-36) Widiatmoko, Widiatmoko; Riyanto, Bambang Sigit; Retnowulan, Heni
Acta Interna The Journal of Internal Medicine Vol 12, No 2 (2023): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.98239

Background. Chronic obstructive pulmonary disease (COPD) is a disease of high prevalence that is characterized by irreversible airway obstruction. The most frequent symptoms such as tightness during activity and fatigue have a negative impact on the quality of life of patients and limit physical activity in everyday life. One of the goals of COPD therapy is to improve the quality of life of patients. Pursed-Lips Breathing (PLB) as one of the pulmonary rehabilitation options is known to improve breathing patterns, increase tidal volume, and reduce shortness of breath.Objective. To demonstrate the influence of PLB on the quality of life of COPD patients as measured by The Short-Form 36 questionnaire.Methods. A prospective, single-blind, randomized controlled trial study was conducted at RSKP Paru Respira, Bantul, Yogyakarta. The subjects of the study were stable COPD patients who met the inclusion and exclusion criteria. The SF-36 score was assessed in both groups before and after 28 days (4 weeks). The independent variable PLB treatment and the dependent variable SF-36 score were measured before and after treatment. Statistical analysis was carried out by a mean difference test between the treatment group and the control group.Results. Seventy-eight patients (mean age, 63 years) were randomized into the treatment group (n=41 patients) continuing standard therapy and doing 8-minute PLB for 28 days and the control group (n=37 patients) only continuing the previous standard therapy. The PLB treatment group showed an increase in the mean delta of the SF-36 score which was especially significant in aspects of physical function, physical role, and social function. There was a significant difference in the increase of average total SF-36 score in the PLB treatment (8.93 ± 15.85) compared to the control group (2.09 ± 8.15) of the 100 points total score (p=0.033).Conclusion. There was an improvement in the SF-36 score in COPD patients who received standard therapy and pulmonary rehabilitation with a PLB technique for four weeks.

Title

Found 10 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 10 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 10 Documents
Search