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All Journal International Journal of Integrated Health Sciences Jurnal Biomedika dan Kesehatan
Elrade Rofaani
Pusat Teknologi Farmasi dan Medika Badan Pengkajian dan Penerapan Teknologi (BPPT)
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Integrating Basic Sciences into Global Health by Implementing the Translational Research Shahib, Muhamad Nurhalim; Dhyanawati, Diah; Rofaani, Elrade
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

An emphasize on herbal medicine in cancer therapy is also included as an example of translational research implementation. A translational research in Faculty of Medicine, Universitas Padjajaran, has been conducted to develop a novel genomic approach (herbal genomic) on herbal crude extracts. This study focuses on the effects of the extracts on specific gene expressions. In this aspect, the concept of molecular targets is slightly different from pharmaceutical approaches  that aim to find compounds that interact with a specific molecule or macromolecule with known function. In this research strategy, the herbal genomic approaches involve screening of herbal extracts that affect particular gene expression related to cell responses rather than a single proteins. The determination of herbal concentration is based on differential gene expression before and after treatment which is analyzed by real time PCR. The results are being compared to the existing small molecule (active molecule) on the gene expressions. All these academic activities require biomedical research workforce to implement the translational research which, in the Faculty of Medicine, Universitas Padjadjaran, is fulfilled by involving the postgraduate students. New crude extract formulation plus specific gene expression profile is a concept required for developing chemotherapeutic agent in Indonesia. Hopefully, this review can support increased cooperation between hospital and academic institutions in implementing translational research in Indonesia.    DOI: 10.15850/ijihs.v1n1.86
The Potential of Mesenchymal Stem Cells in Wound Healing using Nanofiber Scaffold: A Mini Review Rambe Purba, Priskila Natasya; Rofaani, Elrade; Astirin, Okid Parama
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Currently, the use of mesenchymal stem cells (MSCs) in cell therapy is growing as a means to repair damaged cells. MSCs are multipotent stem cells that can differentiate into a variety of specialized cell types in various tissues. Adipose tissue, bone marrow, umbilical cord, and placenta are possible sources of MSCs. MSCs produce various bioactive molecules, called secretome that have effects on skin cells by mediating growth factors and cytokines. MSCs can actively contribute to wound healing through several phases, including promoting fibroblast migration, neovascularization, secreting anti-inflammatory cytokines, and re-epithelialization. To improve therapeutic effectiveness, appropriate biomaterials on nanofiber scaffolds were created to mimic the natural extracellular matrix and attract fibroblasts into the skin layer. The purpose of this review is to evaluate the research on the utilization of MSCs with various nanofiber scaffolds in the wound healing process in vitro. The result of this review is that there are several natural and synthetic polymers used as scaffold materials that are biocompatible, thus increasing the healing potential of wound tissue. MSCs when co-cultured in nanofiber scaffolds activate several mechanism pathways, such as expressing genes or growth factors related to wound healing. It is concluded that the utilization of biopolymers in MSC-seeded scaffold designs can contribute to the enhancement of wound healing and tissue regeneration.
Co-Authors Diah Dhyanawati M. Nurhalim Shahib Okid Parama Astirin Rambe Purba, Priskila Natasya