Yohanes Sardjono
Center of Accelerator Science and Technology, National Nuclear Energy Agency, Yogyakarta 55281, Indonesia

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Boron Neutron Capture Therapy for Cancer: Future Prospects in Indonesia Bagaswoto Poedjomartono; Hanif Afkari; Edy Meiyanto; Alan Bangun; Yohanes Sardjono
ASEAN Journal on Science and Technology for Development Vol. 35 No. 3 (2018): Developments in Nuclear Techniques in the Treatment of Cancer
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29037/ajstd.510

Abstract

Boron neutron capture therapy (BNCT) is a form of cancer therapy based on the interaction of low-energy thermal neutrons and boron-10 (10-B) to produce alpha radiation from He-4 and Li-7 with a high linear energy transfer. A beam of neutrons irradiates a boron drug injected into the tumor, resulting in the boron-injected cancer cells receiving a lethal dose of radiation with the surrounding, healthy cells being minimally affected. Two boron drugs have been used clinically in BNCT, boron sodium captate (BSH) and borophenylalanine (BPA), while a third, pentagamaboronon-0 (PGB-0), is currently under development in the Faculty of Pharmacy of Universitas Gadjah Mada, Indonesia. In Indonesia, there has been a growing interest in the study and use of BNCT to treat cancer, as this method is expected to be safer and more effective than traditional cancer treatment methods.
Rockwell Hardness Testing of Pure Nickel Collimators for BNCT Application Erasmus Prakasita; Yohanes Sardjono; Budi Setyahandana
ASEAN Journal on Science and Technology for Development Vol. 36 No. 1 (2019): Vol 36 No 1 (2019)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.157 KB) | DOI: 10.29037/ajstd.525

Abstract

In this study, Rockwell and Brinell hardness testing was used to examine material hardness. These methods were chosen because they are easy to carry out, relatively inexpensive, and almost all sizes and shapes can be tested, in which nickel hardness before and after centrifugal casting are identified and compared. These tests enable the determination of the hardness numbers of nickel collimators using for boron neutron capture therapy. The samples were five nickel plates with a dimension of 4.5 × 4.5 cm and five collimators. The collimators were cylindrical and made using centrifugal casting. The basic principle of the hardness test was to apply loading on the object being tested. The Rockwell test was used to assess the material's hardness from the difference of indentation depth, while the Brinell test was used to determine the hardness from the diameter of indentation. From the results of this test, the hardness number of nickel before centrifugal casting is 168.53 BHN or 86.13 HRB, while the hardness number after centrifugal casting is 115.68 BHN or 64.84 HRB. It can therefore be concluded that centrifugal casting decreased nickel hardness.