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Bone scanning study with Tc-99m-MDP for screening of malignant metastasis in patient with lung carcinoma Bagaswoto Poedjomartono, Bagaswoto Poedjomartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 01 (1990)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.062 KB)

Bone scanning study with Tc-99m-MDP is usually used for screening of malignant metastasis. This method is not invasive, very sensitive but not specific. Indications of bone scanning study are detecting metastasis, evaluation of therapy and follow up the disease. The dosis of Tc-99m-MDP is 15 mCi injected into vena cubiti and after 2-4 hours, scanning will be done. Metastatic lesions are indicated by hyperactive areas on the bone. This scanning is done for evaluation how far the bones are involved in patients with lung carcinoma.Key words: lung carcinoma - bone metastasis - Tc-99m-MDP scanning - radiology - oncology

Hysterosalpingography in infertility Bagaswoto Poedjomartono, Bagaswoto Poedjomartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 16, No 01 (1984)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.191 KB)

Hysterosalpingography is performed by injecting contrast media into the uterus to visualize the uterine cavity and Fallopian tubes. Water-soluble contrast media are used in these examinations. Hysterosalpingographic examination is very important for the diagnosis of infertility and some gynecologic abnormalities.Between January-December 1981 hysterosalpingography had been performed in 79 cases of primary infertility, 28 cases of secondary infertility and 3 cases with abortion history. The hysterosalpingogram demonstrated that 23.64% of all cases were bilateral non-patent and 21.8% unilateral non-patent. Hydrosalpinx was found in 22 cases, 17 cases with bilateral or unilateral non-patent tubes and 5 cases with patent ones. Ten cases showed paratubal filling assosiated with patent and non-patent tubes.Key Words: hysterosalpingography - hydrosalpinx - infertility - contrast media - Fallopian

Bone Pain Palliative Therapy: The Role of Samarium (Sm)-153 in Bone Metastatic Tumor* Poedjomartono, Bagaswoto
Indonesian Journal of Cancer Vol 3, No 2 (2009): Apr - Jun 2009
Publisher : "Dharmais" Cancer Center Hospital

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Pengobatan kanker dengan radioisotop, baik untuk terapi maupun paliatif, sudah sering dilakukan. Hal ini sudah banyak digunakan di daerah-daerah dengan angka prevalensi kanker tinggi, misalnya penggunaan radioiodine (I-131) untuk kanker tiroid deferensiasi baik dan Strontium(Sr)-89 serta Samarium(Sm)-153 untuk mengontrol rasa nyeri pada tulang yang terkena metastasis keganasan kanker. Sm-153 EDTMP mempunyai efek yang baik untuk mengobati pasien dengan metastasis ke tulang. Hampir semua pasien merasakan adanya penurunan rasa nyeri tulang dalam 24 jam sampai 3 hari setelah pemberian Sm-153 EDTMP. Sangat sedikit efek samping yang dilaporkan, di antaranya adanya sakit kepala ringan yang muncul dalam 24 jam setelah suntikan intravena Sm-153 EDTMP. Makalah ini akan membahas dan mengevaluasi efek terapeutik dan paliatif dari Sm-153 EDTMP pada pasien dengan keganasan yang bermetastasis ke tulang.Kata kunci: metastasis tulang, nyeri tulang, Sm-153 EDTMPÂ

Kemoembolisasi Transarterial (TACE) pada Karsinoma Hepatoselular (KHS) Poedjomartono, Bagaswoto; -, Sudarmanto
Indonesian Journal of Cancer Vol 3, No 3 (2009): Jul - Sep 2009
Publisher : "Dharmais" Cancer Center Hospital

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Karsinoma hepatoselular (KHS) merupakan 5,6% dari seluruh kanker pada manusia. KHS menempati urutan ke-5 pada laki-laki dan ke-9 pada wanita. KHS juga menempati urutan ke-3 dari kanker sistem gastrointestinal setelah kanker kolorektal dan kanker lambung. Tingkat kematiannya sangat tinggi, menempati urutan ke-2 setelah kanker pankreas. Insiden karsinoma hepatoselular (KHS) di Asia Tenggara relatif tinggi pada laki-laki (18,35) dan wanita 5,70 per 100.000 penduduk. KHS mempunyai hubungan kuat dengan infeksi kronik virus hepatitis B (HBV), baik secara epidemiologis, klinis, maupun eksperimental. Karsinoma hepatoselular (KHS) juga mempunyai hubungan dengan virus hepatitis C (HCV), sirosis hati, aflatoxin, obesitas, diabetes melitus, dan alkohol.Diagnosis karsinoma hepatoselular (KHS) dapat ditegakkan dengan pemeriksaan biopsi sitohistologis, laboratorium, dan radiologi. Pemeriksaan laboratoris AFP yang sama atau lebih dari 400 ng/mL dan imajing USG sudah dapat digunakan sebagai parameter diagnosis karsinoma hepatoselular (KHS). Sedang pemeriksaan dengan CT atau MRI dapat mengidentifikasi adanya nodul hipervaskular arteri pada penyakit hati yang kronis.Pada KHS stadium dini, sebelum timbul vaskular yang dominan, bedah merupakan terapi pilihan. Tetapi, jika sudah timbul vaskularisasi yang dominan maka terapi kombinasi di antara bedah, ablasi, dan chemo dapat merupakan pilihan. Sedangkan pada tahap yang sudah menengah lanjut, terapi TACE merupakan pilihan.Keywords: KHS, KHS stadium menengah lanjut, TACE

In Vitro and In Vivo Test of Boron Delivery Agent for BNCT Sista Dyah Wijaya; Bagaswoto Poedjomartono; Yohannes Sardjono
Indonesian Journal of Physics and Nuclear Applications Vol 4 No 2 (2019)
Publisher : Fakultas Sains dan Matematika Universitas Kristen Satya Wacana

BNCT is an alternate therapy for treating cancer. The principle of BNCT involves a neutron boron uptake and a fission reaction that produce alpha particles and Li ions with a high level of linear energy transfer in the tissue. It is effective in killing tumor cells. To administer boron in the tumor cells, a boron delivery agent is needed. Thus far, there are a variety of boron delivery agents that have been developed. To date, just two main boron-based drugs, BPA and BSH, have been used for clinical studies. Many other boron delivery agents have been evaluated in vivo and in vitro but have not been evaluated clinically. Therefore, the other boron delivery agents have not been used in BNCT clinical studies.

Bone scanning study with Tc-99m-MDP for screening of malignant metastasis in patient with lung carcinoma Bagaswoto Poedjomartono Bagaswoto Poedjomartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 01 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.062 KB)

Bone scanning study with Tc-99m-MDP is usually used for screening of malignant metastasis. This method is not invasive, very sensitive but not specific. Indications of bone scanning study are detecting metastasis, evaluation of therapy and follow up the disease. The dosis of Tc-99m-MDP is 15 mCi injected into vena cubiti and after 2-4 hours, scanning will be done. Metastatic lesions are indicated by hyperactive areas on the bone. This scanning is done for evaluation how far the bones are involved in patients with lung carcinoma.Key words: lung carcinoma - bone metastasis - Tc-99m-MDP scanning - radiology - oncology

Hysterosalpingography in infertility Bagaswoto Poedjomartono Bagaswoto Poedjomartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 16, No 01 (1984)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.191 KB)

Hysterosalpingography is performed by injecting contrast media into the uterus to visualize the uterine cavity and Fallopian tubes. Water-soluble contrast media are used in these examinations. Hysterosalpingographic examination is very important for the diagnosis of infertility and some gynecologic abnormalities.Between January-December 1981 hysterosalpingography had been performed in 79 cases of primary infertility, 28 cases of secondary infertility and 3 cases with abortion history. The hysterosalpingogram demonstrated that 23.64% of all cases were bilateral non-patent and 21.8% unilateral non-patent. Hydrosalpinx was found in 22 cases, 17 cases with bilateral or unilateral non-patent tubes and 5 cases with patent ones. Ten cases showed paratubal filling assosiated with patent and non-patent tubes.Key Words: hysterosalpingography - hydrosalpinx - infertility - contrast media - Fallopian

The role of transcatheter arterial chemoinfusion (TACI) in unresectable adenocarcinoma colorectal:a case report Bagaswoto Poedjomartono; P Pramiadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Colorectal cancer (CRC) is the fourth most common cancer in worldwide. In the last 10 years, the mortality rate of CRC decreased by more than 20% and 5-year survival remains approximately 60% due to the rising developments in diagnostic techniques and optimization of surgical, neoadjuvant and palliative therapies. We reported a case of 80-year-old woman with diarrhea, blood in the stool and weight loss for a year. The patient was diagnosed with colonic polyp eight years ago. In double-contrast barium enema (DCBE) showed filling defects in sigmoid with pedunculated form. Optical colonoscopy demonstrated tumor in sigmoid. Computed tomography (CT) abdomen showed circumferential thickening and luminal narrowing of sigmoid colon with stranding of the serosa and mesenteric fat as well as enlarge pericolic nodes without distant metastasis. Based on American Joint Committee on Cancer criteria the stage was T3N1M0. From histopathological diagnosis, the tumor was well differentiated adenocarcinoma. We concluded as unresectable adenocarcinoma colorectal. Patient received transcatheter arterial chemoinfusion (TACI) with oxaliplatin and bevacizunab in three courses every 2 months. After first TACI, symptoms and patient’s performance status improved without systemic side effects. Arteriography imaging showed decrease in tumor staining after third TACI. CT evaluation showed a significant decrease of tumor size, without nodal and distant metastasis.In this case, TACI treatment with oxaliplatin and bevacizumab in unresectable adenocarcinoma colorectaldemonstrated improvement of patient’s performance status, partial response, decrease stage and symptoms, without systemic side effects. It is proven that TACI treatment may be an effective palliative therapy for unresectable colorectal cancer. Further studies should be performed to verify these findings.We reported a case of a woman with unresectable adenocarcinoma colorectal showed good results after received TACI treatment.

Clinical Application of Renograph IR-03 for the Hospital R. Isaris; J. Sumanto; Suharni Suharni; P. Bagaswoto; E. Purwanti
Atom Indonesia Vol 38, No 2 (2012): August 2012
Publisher : PPIKSN-BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/aij.2012.166

The renography using renograph is one of clinical modality to investigate the renal function among other such as laboratory medical check up and X-rays. The prototype of renograph IR-03 designed by BATAN has been constructed and the laboratory tests as well as clinical tests have been carried out at PRPN-BATAN Serpong and General Hospital Dr. Sardjito Jogyakarta, respectively. Cost associated with the clinical use of renograph at the hospital are analyzed according to the two major components: radiopharmaceutical cost and the use of equipment. Annual cost of operational of renograph by estimate number of patient is about 2,000 is IDR. 30.0 millions for radiopharmaceutical 131Iodine. Total Direct Cost is about IDR. 212.5 millions and the Capital Cost for one unit renograph is IDR. 250 millions. The Break Event Point of invest one unit renograph is 1194 procedures (0.597%), or about IDR. 209,475 millions, which the cost for each procedure is IDR. 85,000.-. This value is depending on several variables, especially number of procedure can be reached. The cash flow analyses by Rate of Return (ROR) showed that the value of i* is 22.6% is much greater than the value of MARR or saving rate of interest in the Bank now is about < 10%. The Payback Period calculation to see on how interesting the investment of renograph and its prospect for application in the hospitals showed about 1.818 years, that is good prospect economically. Received: 28 April 2011; Revised: 03 July 2012; Accepted: 07 July 2012

Boron Neutron Capture Therapy for Cancer: Future Prospects in Indonesia Bagaswoto Poedjomartono; Hanif Afkari; Edy Meiyanto; Alan Bangun; Yohanes Sardjono
ASEAN Journal on Science and Technology for Development Vol. 35 No. 3 (2018): Developments in Nuclear Techniques in the Treatment of Cancer
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29037/ajstd.510

Boron neutron capture therapy (BNCT) is a form of cancer therapy based on the interaction of low-energy thermal neutrons and boron-10 (10-B) to produce alpha radiation from He-4 and Li-7 with a high linear energy transfer. A beam of neutrons irradiates a boron drug injected into the tumor, resulting in the boron-injected cancer cells receiving a lethal dose of radiation with the surrounding, healthy cells being minimally affected. Two boron drugs have been used clinically in BNCT, boron sodium captate (BSH) and borophenylalanine (BPA), while a third, pentagamaboronon-0 (PGB-0), is currently under development in the Faculty of Pharmacy of Universitas Gadjah Mada, Indonesia. In Indonesia, there has been a growing interest in the study and use of BNCT to treat cancer, as this method is expected to be safer and more effective than traditional cancer treatment methods.

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