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All Journal Jurnal Epidemiologi Kesehatan Komunitas
Adrian Wiryanata Gorintha
Universitas Udayana
Health Professions Public Health

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Potensi Formulasi Self Microemulsifying Drug Delivery System (SMEDDS) Ekstrak Biji Kedelai (Glycine soja) Terhadap Penurunan Kolesterol pada Penyakit Jantung Koroner I Nengah Raka Swastika; Ni Ketut Ristiani; Adrian Wiryanata Gorintha; Agung Wiwiek Indrayani
Jurnal Epidemiologi Kesehatan Komunitas Vol 6, No 2: Agustus 2021
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v6i2.12190

Abstract

Background: Coronary heart diseases (CHD) is a disorder that caused by blockage of coronary arteries due to the process of atherosclerosis which disrupts the blood supply to the heart muscle. According to Sample Registration System (SRS) Indonesia in 2014, CHD is a second highest cause of death after stroke that is 12,9% of all cause of death in Indonesia. Therefore, this study aims to examining the effect of soybean extract encapsulated with Self Microemulsifying Drug Delivery System (SMEDDS) on LDL levels in coronary heart model rats. Based on various study, isoflavone aglycone genistein is the main flavonoid in soybean seed that has potential as an antioxidant. To increase bioavailability of aglycone isoflavones, a SMEDDS is needed. In this regard, the purpose of this reseach is to examine the potential of soybean seed (Glycine soja) extract to reduced cholesterol in CHD.Methods: The method used is a literature review with literature sources in the form of relevant articles from the search engines, namely Google Scholar, Pubmed, ScienceDirect, and Research Gate. Inclusion criteria included journals containing the keywords “soybean (Glycine soja)”, “Coronary Heart Disease”, “SMEDDS”, and “genistein isoflavone aglycone”.Result: Isoflavone aglycone as an potential antioxidant that is able to bind free radicals and and also lowering LDL, Triglycerides, and glucose levels in hyperglycemic states and increasing HDL.Conclusion : Soybean seed extract with SMEDDS encapsulation have a potential to decrease LDL level in coronary heart disease.
Potensi Kombinasi Adenosine Diphosphate-Ribosylation Like 4c Antisense Oligonuclotide-1316 dengan Polyamidoamine Dendrimer Generasi 4-Anti Surfactant Protein B sebagai Terapi Adenokarsinoma Paru Adrian Wiryanata Gorintha; Andrea Ivena; Putu Aprilyanti Aristadewi; Agung Wiwiek Indrayani
Jurnal Epidemiologi Kesehatan Komunitas Vol 7, No 1: Februari 2022
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v7i1.12497

Abstract

Background: Lung cancer is a disease of the respiratory system that gets special attention because the World Health Organization (WHO) has reported that in 2018, lung cancer was the cancer with the highest number of morbidity and mortality rate in the world. There are several types of lung cancer, one of which is adenocarcinoma, which accounts for about 40% of all lung cancers. In its management, cancer cells often develop resistance to EGFR TKI drugs while Cisplatin and Crizotinib have quite dangerous side effects, namely bradycardia to cardiotoxicity.Methods: The method used is a literature review with literature sources in the form of relevant article from search engine such as Pubmed and Google Scholar that contain keyword “ARL4C ASO-1316”, “lung adenocarcinoma”, “PAMAM Dendrimer Generasi 4” and “anti SFTPB antibody”.Result: The ability of ARL4C ASO-1316 in inhibiting the division and migration of lung adenocarcinoma cells has been proven in vivo and in vitro so that it can provide hope in the form of new modalities in the treatment of lung adenocarcinoma. In addition, the combination with the PAMAM Dendrimer G4-Anti SFTPB carrier can increase the ability to deliver ARL4C ASO-1316 to reach target tissues rapidly and can provide maximum effect in the treatment of lung adenocarcinoma.Conclusion : Adenosine diphosphate-ribosylation like 4c antisense oligonuclotide-1316 with polyamidoamine dendrimer generation 4-anti surfactant protein b should provide novel approaches and new insights for lung adenocarcinoma.
Co-Authors Agung Wiwiek Indrayani Andrea Ivena I Nengah Raka Swastika Ni Ketut Ristiani Putu Aprilyanti Aristadewi