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Eti Meirina Brahmana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Materials Science & Nanotechnology Mathematics Physics Social Sciences

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UJI ANTIOKSIDAN (E)-1-(4-KLOROFENIL)-3-P-TOLILPROP-2-EN-1-ON DAN (E)-1-(4-KLOROFENIL)-3-(4-ISOPROPILFENIL)PROP-2-EN-1-ON Eti Meirina Brahmana; Dahlia Dahlia; Rena Lestari; Jismi Mubarak; Ria Karno; Arief Anthonius Purnama
JURNAL INOVASI PENDIDIKAN DAN SAINS Vol 3 No 1 (2022): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Nahdlatul Wathan Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (728.804 KB) | DOI: 10.51673/jips.v3i1.916

Abstract

Penelitian ini bertujuan untuk menguji aktivitas antioksidan (E)-1-(4-klorofenil)-3-p-tolilprop-2-en-1-on (C1) dan (E)-1-(4-klorofenil)-3-(4-isopropilfenil)prop-2-en-1-on (C2). Penelitian ini bermanfaat sebagai langkah awal dalam pencarian alternatif senyawa antioksidan dan antibiotik baru dari senyawa kalkon. Pengujian bioaktivitas antioksidan dilakukan dengan metode DPPH. DPPH merupakan metode yang cepat, sederhana, dan tidak membutuhkan biaya tinggi dalam menentukan kemampuan antioksidan menggunakan radikal bebas 2,2-diphenyl-1-picrylhydrazil (DPPH). Metode ini sering digunakan untuk menguji senyawa yang berperan sebagai free radical scavengers atau donor hidrogen dan mengevaluasi aktivitas antioksidannya, serta mengkuantifikasi jumlah kompleks radikal-antioksidan yang terbentuk. Bioaktivitas antioksidan senyawa kalkon (E)-1-(4-klorofenil)-3-p-tolilprop-2-en-1-on memiliki nilai IC50 533,9000 ppm dan senyawa kalkon (E)-1-(4-klorofenil)-3-(4-isopropilfenil)prop-2-en-1-on memiliki nilai IC50 718,9054 ppm. Kemampuan senyawa kalkon (E)-1-(4-klorofenil)-3-p-tolilprop-2-en-1-on dan (E)-1-(4-klorofenil)-3-(4-isopropilfenil)prop-2-en-1-on tergolong antioksidan lemah [12]. Kata Kunci : Antioksidan, DPPH, Kalkon
UJI ANTIOKSIDAN (E)-1-(4-KLOROFENIL)-3-P-TOLILPROP-2-EN-1-ON DAN (E)-1-(4-KLOROFENIL)-3-(4-ISOPROPILFENIL)PROP-2-EN-1-ON Eti Meirina Brahmana; Dahlia Dahlia; Rena Lestari; Jismi Mubarak; Ria Karno; Arief Anthonius Purnama
Jurnal Inovasi Pendidikan dan Sains Vol 3 No 1 (2022): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Nahdlatul Wathan Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51673/jips.v3i1.916

Abstract

This study aimed to test the antioxidant activity of (E)-1-(4-chlorophenyl)-3-p-tolilprop-2-en-1-on (C1) and (E)-1-(4-chlorophenyl)-3- (4-isopropylphenyl)prop-2-en-1-on (C2). This research is useful as a first step in the search for alternative antioxidant compounds and new antibiotics from chalcone compounds. The antioxidant bioactivity test was carried out using the DPPH method. DPPH is a method that is fast, simple, and does not require high costs in determining antioxidant capacity using the free radical 2,2-diphenyl-1-picrylhydrazil (DPPH). This method is often used to test compounds that act as free radical scavengers or hydrogen donors and evaluate their antioxidant activity, as well as quantify the number of antioxidant-radical complexes formed. The antioxidant bioactivity of chalcone compounds (E)-1-(4-chlorophenyl)-3-p-tolilprop-2-en-1-on has an IC50 value of 533.9000 ppm and chalcone compounds (E)-1-(4-chlorophenyl) -3-(4-isopropylphenyl)prop-2-en-1-on has an IC50 value of 718.9054 ppm. The ability of chalcone compounds (E)-1-(4-chlorophenyl)-3-p-tolylprop-2-en-1-one and (E)-1-(4-chlorophenyl)-3-(4-isopropylphenyl)prop- 2-en-1-on is classified as a weak antioxidant [12]. Keywords : Antioxidant, DPPH, Chalcone
Co-Authors Arief Anthonius Purnama Dahlia - Jismi Mubarak Rena Lestari, Rena Ria Karno