Henny Anggraini Sadeli
Department of Neurology, Faculty of Medicine, Universitas Padjadjaran Bandung

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Demographic Profile of Knee Osteoarthritis Patients in a Teaching Hospital West Java, 2013 Nugrahaputra, Tranggana; Prabowo, Tertianto; Sadeli, Henny Anggraini
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Background: Osteoarthritis is the most common degenerative musculoskeletal diseases occur worldwide. It usually affects the weight-bearing joint such as knee and vertebra. Osteoarthritis is influenced by various risk factors. The aim of the study was to identify the demographic profile of knee osteoarthritis patients.Methods: A retrospective descriptive study was performed to 247 medical records of knee osteoarthritis patients who attended to Physical Medicine and Rehabilitation of Dr. Hasan Sadikin General Hospital Bandung in 2013. The inclusion criteria were medical records that consisted of age, sex and occupation of the patients, and payment methods. Exclusion criteria were incomplete of the necessary data mentioned in the inclusion criteria. The study was conducted from August until November 2014. The collected data were analyzed and presented using frequency distribution.Results: From all the patients, 40.9% was 60-69 years old, 77.7% were women and 82.6% were retired patients. Most of the patients had a social health insurance.Conclusions: Majority of patients is 60–69 years old women, retired and has the financial protection. [AMJ.2015;2(4):597–600] DOI: 10.15850/amj.v2n4.468
The Analgesic Effect of Pineapple Fruit Juice on Mice binti Hilmi, Ainul Atiqah; Yunivita KD, Vycke; Sadeli, Henny Anggraini
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Althea Medical Journal

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Background: Pain is a feeling stimulated by the nervous system which  can be suppressed by giving an analgesic agent. Some studies revealed that pineapples have an analgesic effect. This study aim was to determine analgesic effect of pineapple on mice.Methods: In this experimental study, the effect was examined by using a writhing method on the 28 male mice. Subjects were divided into 4 groups with 7 mice each. The control group received aquades and other groups received pineapple fruit juice with 20%, 40% and 80% concentration with the dosage of 10 mL/kg/body weight. After 30 minutes, 3% acetic acid was injected intraperitoneally to induce pain. Writhing responseswere observed every 5 minutes for 30 minutes.Results: The result for mean of total writhing reaction was  2.39±0.40, 1.92±0.40, 1.50±2.13, 1.66±0.11 respectively for group 1 to 4. These data indicated a significant decrease of total writhing response in mice with 20%, 40% and 80% concentration compared to control group (p=0.023;p=0.000 and p=0.000 respectively). Most optimal concentration was40% with the protective percentage equal to 71.8%.Conclusion: Pineapple fruit juice concentrations (20%, 40%, and 80%has an analgesic effect with the most optimal concentration of 40%.Keywords: analgesic, pain, pineapple fruit, writhing method Efek Analgesik Jus Buah Nanas Pada Mencit Latar Belakang: Nyeri adalah sensasi perangsangan sistem saraf yang dapat ditekan dengan pemberian zat analgetik. Penelitian sebelumnya menemukan bahwa nanas memiliki efek analgesik. Tujuan penelitian ini adalah untuk mengetahui efek analgesik nanas pada mencit.Metode: Efek analgesik diperiksa dengan menggunakan metode “writhing“ pada 28 mencit jantan. Subyek penelitian dibagi menjadi 4 kelompok masing-masing 7 ekor. Kelompok kontrol menerima aquades dan kelompok lainnya menerima  jus buah nanas secara oral dengan konsentrasi  20%, 40% dan 80% dengan dosis 10 mL/kg/berat badan. Setelah 30 menit, asam asetat 3% disuntikkan intra peritoneal untuk menginduksi nyeri. Respons “writhing” diamati setiap 5 menit selama 30 menit.Hasil: Hasil rata-rata reaksi total ”writhing”adalah 2.39 ± 0.40, 1.92 ± 0.40, 1.50 ± 2.13, 1.66 ± 0.11 masing-masing untuk kelompok 1 sampai 4. Data ini menunjukkan penurunan yang signifikan dari jumlah respon ”writhing” pada tikus dengan 20%, 40 % dan konsentrasi 80% dibandingkan dengan kelompok kontrol (p=0,023; p=0,000; dan p=0,000masing-masing). Konsentrasi optimal adalah 40% dengan persentase pelindung sebesar 71,8%.Simpulan: Konsentrasi  jus buah nanas (20%, 40% dan 80%) memiliki efek analgesik dengan konsentrasi paling optimal pada 40%.Kata Kunci: analgesik, nyeri, nanas, writhingDOI: 10.15850/amj.v1n2.356
Clinical Characteristics of Trigeminal Neuralgia Patients at Dr. Hasan Sadikin General Hospital Bandung Indonesia in 2010–2012 Widihastha, Sri Hudaya; Sadeli, Henny Anggraini; Sunggono, Arifin
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

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Background: Trigeminal neuralgia is a frequently found craniofacial neuralgia. The clinical characteristics of trigeminal neuralgia patients at Dr. HasanSadikin General Hospital, Bandung, Indonesia has never been described before. This study conducted an overview of clinical characteristics of trigeminal neuralgia to determine the characteristic features of trigeminal neuralgia.Methods: This was a non-experimental study using secondary data with a retrospective descriptive method. Data related to medical records of 76 patients with trigeminal neuralgia was collected over a period of 2010 to 2012, treated at Dr.HasanSadikin General Hospital Bandung, Indonesia. Results: Mean age was 57.6 years (range 11 to 84 years), no significant difference in gender (male:females 51.3%:48.7%). Chewing and swallowing was reported as triggering stimuli to 42 (55%) patients. Two patients (2.7%) had suffered pain on bilateral side of the face, 46 (60.5%) patients the right side, and 28 patients (36.8%) on the left side. Pain on maxillary nerve division was found in 58 (76.3%) patients. Sixty one of the patients (80%) received Carbamazepine.Conclusions: The peak age was between the fifth and sixth decades of life with equal representation of male to female incidence. Right side and the maxillary division was found to be the most frequently site of pain. Chewing and swallowing was reported to be the most frequent triggering stimuli and most of patients received Carbamazepine as therapy. [AMJ.2017;4(1):47–51]DOI: 10.15850/amj.v4n1.1020 
Prevalence and Characteristics of Low Back Pain among Productive Age Population in Jatinangor Novitasari, Dini Diwayani; Sadeli, Henny Anggraini; Soenggono, Arifin; Sofiatin, Yulia; Sukandar, Hadyana; Roesli, Rully M. A.
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Althea Medical Journal

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Background: Low back pain is one of the global health issues which prevalence is high among productive ages. It oftentimes corresponds with one’s physical activity during work . The purpose of this study was to determine theprevalence and characteristics of low back pain among productive age population in Jatinangor, West Java, Indonesia.Methods: This study was a cross-sectional descriptive study conducted during the period of August to October 2014 in the three villages in Jatinangor, West Java, Indonesia. In order to determine the demographic data and history of low back pain in the last three months, about 1075 productive age populations were selected through validated questionnaire as the secondary data. These data consisting of 310 subjects were then described according to the pain characteristics and physical activity during work.Results: During three months of examination, s the prevalence of low back pain was 38.4%, with the average age 50–59 years old. Furthermore, about 22.3% subjects were indicated chronic low back pain. The most prevalent qseverity of the pain was dull pain (29.4%), followed with pins and needles pain (23.1%), As the intensity of the pain increased, there was a tendency of increasing interference in daily activities. Static posture was also the most frequent physical activity during work (53.2%).Conclusions: The prevalence of low back pain is more than one third (38.4%) among productive age populations in Jatinangor, West Java, Indonesia.[AMJ.2016;3(3):468–75]DOI: 10.15850/amj.v3n3.863
Hubungan antara Gejala Gangguan Depresi dan Tension-Type Headache (TTH): Studi Eksploratif Setiawan, Cecilia J.; Sadeli, Henny Anggraini; A. Sapiie, Tuti Wahmurti
Majalah Kedokteran Bandung Vol 45, No 1 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Prevalensi gangguan depresi semakin meningkat, termasuk yang berkomorbiditas dengan penyakit fisik. Kondisi medik yang telah lama dikaitkan dengan gangguan depresi adalah tension-type headache (TTH). Komorbiditas ini berhubungan dengan perjalanan penyakit TTH kronik. Tujuan penelitian ini untuk mengetahui gejala gangguan depresi yang paling banyak terjadi pada penderita TTH serta menganalisis hubungan antara gejala tersebut dan tipe TTH yang dialaminya. Penelitian ini merupakan studi potong lintang terhadap 32 penderita TTH yang berobat jalan ke Instalasi Rawat Jalan Departemen Ilmu Penyakit Saraf Rumah Sakit Dr. Hasan Sadikin Bandung selama bulan November hingga Desember 2011 yang didiagnosis gangguan depresi. Subjek diperiksa dengan menggunakan instrumen Hamilton Depression Rating Scale (HDRS). Analisis korelasi dilakukan antara skor gejala gangguan depresi yang paling banyak terjadi dengan tipe TTH, dilanjutkan dengan analisis multivariabel untuk mencari rasio prevalens gejala gangguan depresi yang berkorelasi dengan tipe TTH. Angka kejadian gangguan depresi pada TTH didapatkan pada 32/38 penderita, sedangkan gejala gangguan depresi yang paling banyak ditemukan adalah suasana perasaan depresif, kelelahan/berkurangnya minat, dan ansietas psikis. Suasana perasaan depresif dan kelelahan/berkurangnya minat berkorelasi positif dengan tipe TTH (rs=0,411; p=0,019 dan rs=0,379; p=0,032). Dari analisis regresi logistik, hanya suasana perasaan depresif yang meningkatkan risiko TTH kronik, yaitu sebesar 4,74 kali (IK 95% 1,24–18,02). Simpulan, suasana perasaan depresif merupakan gejala yang paling banyak terjadi dan dapat digunakan untuk penapisan dini gangguan depresi pada penderita TTH serta meningkatkan risiko TTHkronik. [MKB. 2013;45(1):28–34]Kata kunci: Gangguan depresi, gejala gangguan depresi, tension-type headacheRelationship between Depressive Disorder Symptoms and the Tension-Type Headache (TTH): An Explorative StudyThe prevalence rate of depressive disorders is increasing, including those having comorbidity with physical illnesses. One of the medical conditions that has been related to depressive disorder is tension-type headache (TTH). This comorbidity is related to the chronic course of TTH. This research aims to know which kind of depressive symptoms are most frequently found in TTH patients and to analyze the correlation between those symptoms and the type of TTH. This was a cross sectional study on 32 TTH patients who visited the outpatient clinic of the Neurology Department of Dr. Hasan Sadikin Hospital Bandung during the period of November to December 2011 and who were diagnosed as having depressive disorder. They were examined using Hamilton Depression Rating Scale (HDRS). We correlated the scores of depressive disorder symptoms with the type of TTH, followed by mutivariable analysis to find the prevalence ratio of depressive disorder symptoms which correlated with the type of TTH. The results showed the prevalence rate of depressive disorder in TTH was 32/38 patients while the most frequent depressive disorder symptoms of the subjects were depressive mood, fatigue and psychological anxiety. Depressive mood and fatigue were positively correlated with the type of TTH (rs=0.411, p=0.019 and rs=0.379, p=0.032). Logistic regression analysis showed that only depressive mood increased the riskof chronic TTH with a prevalence ratio of 4.74 (IK 95% 1.24–18.02). In conclusions, depressive mood, which is the most frequent symptoms of depressive disorder, can be used in the early screening of depressive disorder in TTH patients and this symptom increased the risk of chronic TTH. [MKB. 2013;45(1):28–34]Key words: Depressive disorder, depressive disorder symptoms, tension-type headache DOI: http://dx.doi.org/10.15395/mkb.v45n1.92
PERBANDINGAN KADAR MIKROALBUMINURIA PADA STROKE INFARK ATEROTROMBOTIK DENGAN FAKTOR RISIKO HIPERTENSI DAN PASIEN HIPERTENSI Putri, S A; Nurimaba, Nurdjaman; Sadeli, Henny Anggraini; Syamsudin, Thamrin
Majalah Kedokteran Bandung Vol 41, No 3
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Mikroalbuminuria berhubungan dengan kerusakan vaskular di sistem glomerular ginjal yang disebabkan oleh faktorfaktor risiko vaskular antara lain: tekanan darah tinggi, diabetes melitus, profil lipid, merokok, usia lanjut, faktor genetika, dan proses aterosklerosis. Mikroalbuminuria juga menggambarkan kerusakan vaskular di tempat lain termasuk di serebral. Hubungan mikroalbuminuria dengan penyakit serebrovaskular belum banyak diketahui. Penelitian ini merupakan penelitian kasus kontrol dengan pendekatan analitik observasional yang dilakukan di Rumah Sakit Hasan Sadikin Bandung periode Desember 2007–Juli 2008. Pemeriksaan mikroalbuminuria dilakukan pada kelompok kasus (35 subjek stroke infark aterotrombotik dengan faktor risiko hipertensi saja) dan kelompok kontrol (35 subjek dengan hipertensi). Perbandingan kadar mikroalbuminuria antara kedua kelompok dianalisis dengan uji T Independen. Sementara untuk faktor penentu kejadian stroke digunakan uji regresi logistik multipel. Rata-rata kadar miroalbuminuria pada kelompok kasus lebih tinggi (54,76 mg/24 jam) dibanding kelompok kontrol (23,56 mg/24 jam) dengan perbedaan yang bermakna (p=0,013). Hasil analisis regresi logistik multipel menunjukkan miroalbuminuria merupakan faktor penanda independen kejadian stroke infark aterotrombotik pada pasien denganfaktor risiko hipertensi (p=0,032; OR=2,91;CI95%). Pasien hipertensi dengan mikroalbuminuria memiliki potensi terjadinya stroke infark aterotrombotik 2,91 kali dibandingkan pasien hipertensi tanpa mikroalbuminuria. Disarankan pemeriksaan mikroalbuminuria sebagai pemeriksaan rutin pada pasien hipertensi untuk preventif primer stroke infark aterotrombotik.Kata kunci: Stroke infark aterotrombotik, faktor risiko hipertensi, mikroalbuminuriaCOMPARISON OF MICROALBUMINURIA LEVEL BETWEENATHEROTROMBOTIC INFARCTION STROKE WITH HYPERTENSION RISK FACTOR AND PATIENT WITH HYPERTENSIONMicroalbuminuria is a marker of vascular damage in glomerular system caused by vascular risk factors : hypertension, diabetes mellitus, lipid profile, smoking, older age, genetic and atherosclerosis. Microalbuminuria is a window of vasculature damage in cerebrovascular system. Correlation between microalbuminuria and cerebrovascular disease is not well established. This was an observational analytical case control study, conducted on December 2007 to July 2008 in Hasan Sadikin Hospital Bandung. Measurement of microalbuminuria level was done in case group (35 subjects atherotrombotic infarction stroke with hypertension as the risk factor) and control group (35 subjects with hypertension). Comparison of microalbuminuria level were analyzed with independent T test. Determinant factor for atherotrombotic infarction stroke incidence was analyzed with multiple regression logistic. Mean rate of microalbuminuria level in case group was higher (54.76 mg/24 hours) compared with control (23.56 mg/24 hours) and comparison was significant (p=0.013). Multiple logistic regression analyzed that microalbuminuria as an independent determinant factor for atherotrombotic infarction stroke in patients with hypertension (p=0.032, OR=2.91, CI95%). Patients with hypertension and microalbuminuria had an increased risk for atherotrombotic infarction stroke 2,91 times than hypertension without microalbuminuria. Microalbuminuria level suggested as a routine examination in patients with hypertension for primary prevention of atherotrombotic infarction stroke.Key words: Atherotrombotic infarction stroke, hypertension, microalbuminuria DOI: http://dx.doi.org/10.15395/mkb.v41n3.244