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All Journal Jurnal Ilmu dan Teknologi Kelautan Tropis Journal of the Indonesian Tropical Animal Agriculture
M. Safitri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Library & Information Science

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INDONESIAN THROUGHFLOW TRANSPORT VARIATIONS AND OCEANOGRAPHIC’S PARAMETER IN TIMOR SEAS AS AN INDICATION OF ENSO EVENTS M. Safitri; S. Y. Cahyarini; M. R. Putri
Jurnal Ilmu dan Teknologi Kelautan Tropis Vol. 4 No. 2 (2012): Elektronik Jurnal Ilmu dan Teknologi Kelautan Tropis
Publisher : Department of Marine Science and Technology, Faculty of Fisheries and Marine Science, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.673 KB) | DOI: 10.29244/jitkt.v4i2.7800

Abstract

Variation of Indonesian Throughflow transport, salinity, and temperature at surface level of Timor Seas monthly, seasonal, and annual mean scale was studied using the datasets provided by IRI/LDEO Climate Data Library i.e Simple Ocean Data Assimilation (SODA) for the salinity. The period data used in this study was 1995-2004, ERSST for the temperature. The Indonesian Thourghflow transport was obtained from Hautala et al. (2001). Result of this study showed there was influence of monsoon and ENSO on oceanographic parameters. During the South East (SE) monsoon, an emptiness on the surface water occurred in Timor Seas due to the easterly wind, which causes the upwelling. The results was also shown that during the SE monsoon the average temperature was 26.84oC, salinity was 34.35, and Indonesian Throughflow transpor was -0.34 Sv. While during the North Western (NW) monsoon the average temperature was 29.6 oC, salinity was 34.22, and the Indonesian Throughflow transport was -0.27 Sv. The negative value (-) means that the flow toward the Indian Ocean. In addition, based on temporal correlation between Indonesian Throughflow transport and NINO 3.4 index was found that the annual mean variability increases (-0.18 Sv) during La Niña period and decreased (-0.13 Sv) during period El Niño. These indicated that ENSO phenomena influenced the transport across the Equatorial Pacific east-west. Keywords: Indonesian throughflow, salinity, temperature, SODA, Monsoon, ENSO, Timor Seas.
In silico's study of Ketepeng leaf (Cassia alata L.) as inhibitor of aspartic protease from Boophillus microplus as a natural acaricide of ticks in cattle Purwono, R. M.; Miftahurridho, Z.; Safitri, M.; Supriyono, S.; Yusriani, R.; Prasetyo, B. F.
Journal of the Indonesian Tropical Animal Agriculture Vol 50, No 1 (2025): March
Publisher : Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jitaa.50.1.57-66

Abstract

The objective of this study was to evaluate the potential of Cassia alata L. leaf extract as an anti-tick agent through molecular docking analysis against the aspartic protease enzyme from Ixodes ricinus (IrCD1). The study aimed to identify natural compounds that could serve as safer alternatives to syn-thetic acaricides for controlling Boophilus microplus, a major ectoparasite affecting cattle.The research utilized an in silico approach, employing molecular docking techniques to assess the binding affinity of 14 secondary metabolites from Cassia alata leaves against IrCD1. The receptor structure (PDB ID: 5N7Q) was obtained from the Protein Data Bank, while ligand structures were sourced from PubChem and KNApSAcK. The docking process was performed using YASARA Structure, with binding free energy (ΔG) and dissociation constant (Kd) values analyzed for ligand-receptor interactions. Addition-ally, the bioavailability of the selected compounds was assessed using Lipinski’s Rule of Five. The results identified four key metabolites—chrobisiamone A, chrysophanol, quercetin, and rhein—as the most promising inhibitors, with binding free energy values lower than the native ligand, pepstatin. Chrobisiamone A demonstrated the strongest interaction with IrCD1, indicating its potential as a potent acaricidal compound. The study also found that these compounds exhibit strong hydrogen bonding and hydrophobic interactions at the receptor’s active site, enhancing their inhibitory potential. In conclu-sion, the findings support the potential development of organic acaricides derived from Cassia alata L. leaves, with chrobisiamone A emerging as a promising candidate. Further in vitro and in vivo studies are needed to validate its efficacy and safety in tick control applications.
Co-Authors M. R. Putri Miftahurridho, Z. Prasetyo, B. F. Purwono, R. M. S. Supriyono S. Y. Cahyarini Yusriani, R.