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All Journal Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Jurnal Ilmu Kefarmasian Indonesia Environmental and Materials
ENDANG SAEPUDIN
UNIVERSITAS INDONESIA
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Control & Systems Engineering Energy Engineering Environmental Science Health Professions Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Public Health

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Isolasi, Indentifikasi dan Uji Aktivitas Sitotoksik Skoplatin dari Daun Macaranga hispida(Blume) Mull. Arg MEGAWATI MEGAWATI; MUHAMMAD HANAFI; ENDANG SAEPUDIN; SOFA FAJRIAH
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3402.776 KB)

Abstract

Skopoletin diisolasi dari ekstrak metanol daun Macaranga hispida. Ekstrak daun diisolasi data spektroskopi dan dibandingkan dengan referensi. Uji sitotoksisitas skopoletin dengan menggunakan kromatografi dengan pelarut bergradien. Penentuan struktur kimia berdasarkan menggunakan metode assay MTT terhadap sel MCF-7 dan T47D menunjukkan aktivitas sitotoksik yang kuat dengan IC50 51,5 dan 66,5 μg/mL
EFFECT OF GAMMA IRRADIATION ON PHYTOCHEMICAL CONTENT AND ANTICANCER ACTIVITIES OF ROSELLE (Hibiscus sabdariffa Linn) Susanto Susanto; Endang Saepudin; Hendig Winarno; Ermin Katrin Winarno; deudeu lasmawati
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 24, No 1 (2023): February 2023
Publisher : HIMNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jstni.2023.24.1.6846

Abstract

Gamma irradiation is widely used in herbal medicine industries as an efficient preservative method in reducing microorganism contaminants. The aim of this study was to evaluate the effect of gamma irradiation at the doses of 5; 7.5; and 10 kGy on H. sabdariffa ethanolic extract (HS-EE). The Co-60 was used for irradiation the samples. The phytochemical content of HS-EE was carried out by total microorganism analysis using dilution method, TPC by Follin-Cicalteu method, TFC by aluminium chloride colorimetric method, antioxidant activity using DPPH method, TLC profiling on silica gel F254, in vitro anticancer activity using A-549, HUT-78, and MCF-7 cancer cell lines. The irradiation at 10 kGy caused the total bacteria decreased, while dose of 5 kGy could eliminate the total mold. Irradiation at 5 kGy caused TPC, TFC, and antioxidant activity decreased by 5-11%. TLC chromatograms analysis confirmed that one of the compounds contained in HS-EE was quercetin. The HS-EE has the strongest anticancer property against HUT-78 (IC50 10.51 µg/mL) followed by against MCF-7 (IC50 13.39 µg/mL), and A-549 (IC50 14.19 µg/mL). It can be concluded that irradiation at a dose of 10 kGy could remove total bacteria and molds, decreasing the phytochemical content and anticancer activities of HS-EE. It is recommended to increase the active ingredient level in the formulation.
Carbon-coated nickel foam for hypochlorous acid sensor Afiten Rahmin Sanjaya; Hanzhola Gusman Riyanto; Isnaini Rahmawati; Yulia Mariana Tesa Ayudia Putri; Dede Nurhalimah; Endang Saepudin; Yudistira Tesla; Yuni Krisyuningsih Krisnandi
Environmental and Materials Vol. 1 No. 1: Juni (2023)
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/eam.v1i1.2023.105

Abstract

The electrochemical detection method of hypochlorous acid (HOCl) using carbon foam electrodes have been successfully developed. The carbon foam was prepared from carbon-coated nickel foam which is synthesized using a hydrothermal-carbonization method. SEM characterization indicated that the optimum synthesis of carbon-coated nickel foam has been achieved on the 4th layer coating process with an expected spherical structure, while characterization using FTIR and Raman spectroscopy confirmed the formation of graphitic material with D band and G band characteristics. An electroactive surface area of ​​0.0236 cm2 was achieved. Cyclic voltammetry of HOCl in 0.1 M phosphate buffer solution pH 6.0 showed the best current response for HOCl reduction occurs at a potential of -0.3 V (vs. Ag/AgCl). Further detection of HOCl using amperometry technique in the concentration range of 2-200 μg/mL showed good linearity with sensitivity of 9.112 mA/µg/L and an estimated detection limit of 1.96 µg/mL. Good repetition is indicated by the RSD value of 2.499 % (n=5). This developed sensor also showed good selectivity in the presence of interference compounds, such as FeCl2 and CuSO4. Besides, the determination of HOCl in tap water has been successfully conducted and generated a comparable result with the UV-VIS method (3.30 µg/mL hypochlorite). The results indicated that the developed sensor is promising for the detection of HOCl in environmental applications.
Preparation of boron-doped diamond microelectrodes to determine the distribution size of platinum nanoparticles using current transient method Aliyah; Reza Rizqi Nurhidayat; Afiten Rahmin Sanjaya; Rahmat Wibowo; Yasuaki Einaga; Endang Saepudin; Tribidasari Anggraningrum Ivandini
Environmental and Materials Vol. 1 No. 1: Juni (2023)
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/eam.v1i1.2023.117

Abstract

Boron-doped diamond (BDD) microelectrodes were prepared to investigate the correlation of hydrazine oxidation current responses with Pt nanoparticle (Pt NP) size distribution. The BDD film was grown on the surface of a tungsten needle with a diameter of 25 µm. An average particle size of around 5 µm BDD crystalline was successfully synthesized using a microwave plasma-assisted chemical vapor deposition technique. The Raman spectrum confirmed the presence of diamond formation as indicated by peaks corresponding to C-C sp3 bonds, while X-ray photoelectron spectroscopy spectrum showed the presence of C-H and C-OH bonds on the surface of the BDD microelectrode. Meanwhile the Pt nanoparticles was synthesized through reduction reaction of  PtCl62- solution using NaBH4 with citric acid as the capping agent. Particles size between 4.46 to 4.78 nm were observed by using TEM measurements. The BDD microelectrodes were utilized to investigate the relationship between Pt nanoparticle size distribution and the current generated from the oxidation reaction of 15 mM hydrazine in a 50 mM phosphate buffer solution pH 7.4 in the presence of 1.0 mL nanoparticle solutions. A current range of 5 and 6 nA with a noise level of 0.15 nA was observed showing a good correlation with the particle sizes of Pt NPs. Comparison was also performed with the measurements using Au microelectrodes, indicated that the prepared BDD microelectrodes is promising for the measurements of nanoparticle sizes distribution, especially Pt NPs.
Co-Authors Afiten Rahmin Sanjaya Aliyah Dede Nurhalimah deudeu lasmawati Ermin Katrin Winarno Hanzhola Gusman Riyanto Hendig Winarno Isnaini Rahmawati Ivandini Tribidasari Anggraningrum MEGAWATI MEGAWATI MUHAMMAD HANAFI Rahmat Wibowo Reza Rizqi Nurhidayat Sofa Fajriah Susanto Susanto Yasuaki Einaga Yudistira Tesla Yulia Mariana Tesa Ayudia Putri Yuni Krisyuningsih Krisnandi