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All Journal Makara Journal of Science Environmental and Materials
Riyanto, Hanzhola Gusman
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Chemical Engineering, Chemistry & Bioengineering Control & Systems Engineering Energy Engineering Physics

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Carbon-coated nickel foam for hypochlorous acid sensor Sanjaya, Afiten Rahmin; Riyanto, Hanzhola Gusman; Rahmawati, Isnaini; Putri, Yulia Mariana Tesa Ayudia; Nurhalimah, Dede; Saepudin, Endang; Tesla, Yudistira; Krisnandi, Yuni Krisyuningsih
Environmental and Materials Vol. 1 No. 1: (June) 2023
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/eam.v1i1.2023.105

Abstract

The electrochemical detection method of hypochlorous acid (HOCl) using carbon foam electrodes have been successfully developed. The carbon foam was prepared from carbon-coated nickel foam which is synthesized using a hydrothermal-carbonization method. SEM characterization indicated that the optimum synthesis of carbon-coated nickel foam has been achieved on the 4th layer coating process with an expected spherical structure, while characterization using FTIR and Raman spectroscopy confirmed the formation of graphitic material with D band and G band characteristics. An electroactive surface area of ​​0.0236 cm2 was achieved. Cyclic voltammetry of HOCl in 0.1 M phosphate buffer solution pH 6.0 showed the best current response for HOCl reduction occurs at a potential of -0.3 V (vs. Ag/AgCl). Further detection of HOCl using amperometry technique in the concentration range of 2-200 μg/mL showed good linearity with sensitivity of 9.112 mA/µg/L and an estimated detection limit of 1.96 µg/mL. Good repetition is indicated by the RSD value of 2.499 % (n=5). This developed sensor also showed good selectivity in the presence of interference compounds, such as FeCl2 and CuSO4. Besides, the determination of HOCl in tap water has been successfully conducted and generated a comparable result with the UV-VIS method (3.30 µg/mL hypochlorite). The results indicated that the developed sensor is promising for the detection of HOCl in environmental applications.
Preliminary Molecular Study of Chloramphenicol Anchoring on Laccase Enzyme from Trametes hirsuta Riyanto, Hanzhola Gusman; Sanjaya, Afiten Rahmin
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

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Abstract

Antibiotics are one of emerging pollutants generally emitted from livestock production and the food industry to the environment. The presence of this pollutant could initiate the development of resistant bacteria that can be fatal to human health. The degradation of antibiotics using enzymes or microbe could be an alternative because the residue or intermediate product is less harmful than of the conventional method. This research aims to support a preliminary study of the degradation of antibiotics using enzyme through molecular docking via Molecular Operating Environment software and molecular dynamics (MD) study via CABSFLEX 2.0 and WebGro macromolecular simulations. The molecular docking of the laccase-chloramphenicol complex has low binding energies of approximately −8.1350 and −8.2290 kcal/mol for both rigid and flexible methods, respectively, indicating that the formation of the complex is advantegous. MD simulation further revealed a decrease in rigidity after the interaction with the ligand. Hydrogen bonding analysis indicated up to five hydrogen bonds in the complex, underscoring the robustness of the enzyme--ligand interaction. These results collectively contribute to our understanding of the efficacy of enzyme-mediated antibiotic degradation and emphasize the potential for this approach to mitigate environmental and health concerns associated with antibiotic pollution
Co-Authors Endang Saepudin, Endang Nurhalimah, Dede Putri, Yulia Mariana Tesa Ayudia Rahmawati, Isnaini Sanjaya, Afiten Rahmin Tesla, Yudistira Yuni Krisyuningsih Krisnandi, Yuni Krisyuningsih