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Agus Purwanggana
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Formulasi Gel Antijerawat Dengan 1,5-Bis(3’-Etoksi-4’-Hidroksifenil)-1,4-Pentadien-3-On (EHP) Sebagai Bahan Antibakteri Esti Mulatsari; Esti Mumpuni; Agus Purwanggana; Siti Marsha Dyah Kusumaningtyas
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1085

Abstract

Acne is a skin disease that causes non-inflammatory follicular papules, nodules, pustules and inflammatory papules. There are various oral and topical anti-acne preparations on the market. Gels are topical preparations that have better absorption than cream preparations. The anti-acne gel is formulated with antibacterial active compounds. The compound 1,5-bis(3’-ethoxy-4’-hydroxyphenyl)-1,4-pentadien-3-one (EHP) is one of the curcumin analogue compounds that have been successfully synthesized by Mumpuni et al, 2010. EHP has the potential to inhibit growth of pathogenic microbes such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Salmonella typhi, and has anti-inflammatory activity. This study aims to make an anti-acne gel formula with the active ingredient EHP as an antimicrobial agent. The formula was tested for physical and chemical stability including organoleptic, spreadability, homogeneity, viscosity, flow properties, microbiological activity and skin irritation ability. EHP is formulated in gel preparations in various concentrations. Stability test of gel preparations was carried out at a temperature of 40 °C; RH ± 75% for 4 weeks.The results showed that EHP can be formulated into gel preparations that meet the physical and chemical quality requirements. Gel preparations with the active ingredient EHP 0.1%; tretionine 0.01%; carbopol 940 1.0%; triethanolamine 1.0%; propylenglycol 15%; ethanol (96%) 10%; can inhibit the Propionibacterium acnes bacteria with a diameter of 19.6 mm in the inhibition area, the skin irritation test of rabbits does not cause irritation, thus the gel preparation with the active ingredient EHP is suitable to be developed as an anti-acne gel product.
Formulasi dan Evaluasi Larutan Pencuci Mulut dengan Bahan Antimikroba Senyawa 1,5-Bis (3’-Etoksi-4’-Hidroksifenil)-1,4-Pentadien-3-on Esti Mumpuni; Agus Purwanggana; Esti Mulatsari; Ryan Pratama
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (585.432 KB) | DOI: 10.35814/jifi.v17i1.615

Abstract

1,5-bis (3-ethoxy-4-hydroxyphenyl) -1,4-pentadien-3-one (EHP) compound is an analogous compound of curcumin which has antimicrobial activity. In this study, the formulation and evaluation of mouthwash was carried out with EHP as an antimicrobial ingredient. The formulation of mouthwash was made with various concentrations of EHP 3, 6, 12, 16 and 18 ppm. Evaluation of mouthwash included organoleptic test, pH, clarity, density and antimicrobial activity against Staphylococcus aureus, Steptococcus mutans, and Candida albicans. Antimicrobial test was done by agar diffusion method. The results of organoleptic test obtained mouthwash was clear blue liquid, the aroma of mint, and fresh cold taste; pH range of 6.15 - 6.74; density of 1.0419 - 1.0561 g/cm3. The evaluation of mouthwash showed that the mouthwash was stable in storage for 1 month at 40 °C. Antimicrobial tests showed the diameter of inhibitory zone against Staphylococcus aureus (ATCC 6538); Streptococcus mutans (ATCC 31987) and Candida albicans (ATCC 10231) ranged from 6.2 to 8.4 mm at the concentration of EHP 18 bpj. The results showed that EHP compound was potential as antimicrobial ingredient in moutwash formula.
Co-Authors Esti Mumpuni Mulatsari, Esti Ryan Pratama Siti Marsha Dyah Kusumaningtyas