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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Magistrorum et Scholarium: Jurnal Pengabdian Masyarakat Journal of Natural Product for Degenerative Diseases

Esti Mumpuni

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Author-ID : 3682499

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Other

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Articles

Formulasi Gel Antijerawat Dengan 1,5-Bis(3’-Etoksi-4’-Hidroksifenil)-1,4-Pentadien-3-On (EHP) Sebagai Bahan Antibakteri Esti Mulatsari; Esti Mumpuni; Agus Purwanggana; Siti Marsha Dyah Kusumaningtyas
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1085

Acne is a skin disease that causes non-inflammatory follicular papules, nodules, pustules and inflammatory papules. There are various oral and topical anti-acne preparations on the market. Gels are topical preparations that have better absorption than cream preparations. The anti-acne gel is formulated with antibacterial active compounds. The compound 1,5-bis(3’-ethoxy-4’-hydroxyphenyl)-1,4-pentadien-3-one (EHP) is one of the curcumin analogue compounds that have been successfully synthesized by Mumpuni et al, 2010. EHP has the potential to inhibit growth of pathogenic microbes such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Salmonella typhi, and has anti-inflammatory activity. This study aims to make an anti-acne gel formula with the active ingredient EHP as an antimicrobial agent. The formula was tested for physical and chemical stability including organoleptic, spreadability, homogeneity, viscosity, flow properties, microbiological activity and skin irritation ability. EHP is formulated in gel preparations in various concentrations. Stability test of gel preparations was carried out at a temperature of 40 °C; RH ± 75% for 4 weeks.The results showed that EHP can be formulated into gel preparations that meet the physical and chemical quality requirements. Gel preparations with the active ingredient EHP 0.1%; tretionine 0.01%; carbopol 940 1.0%; triethanolamine 1.0%; propylenglycol 15%; ethanol (96%) 10%; can inhibit the Propionibacterium acnes bacteria with a diameter of 19.6 mm in the inhibition area, the skin irritation test of rabbits does not cause irritation, thus the gel preparation with the active ingredient EHP is suitable to be developed as an anti-acne gel product.

Pengaruh Crude Fukoidan dari Ekstrak Sargassum crassifolium terhadap Kadar ICAM-1 dan VCAM-1 pada Sel Raw 264.7 yang Diinduksi Lipopolisakarida Ayu Werawati; Esti Mumpuni; Kusmardi Kusmardi; Dian Ratih Laksmitawati; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Inflammation is the response of vascular tissue to infection and damaged tissue to remove agents that cause inflammation. Macrophages are the dominant cells in the inflammatory reaction. Adhesion of leukocytes to vascular endothelium is a main feature of the inflammatory process. The presence of adhesion molecules, such as ICAM-1 and VCAM-1, can lead to adhesion of monocytes and lymphocytes to endothelial cells via bonding adhesion molecules to endothelial cells. Crude fukoidan derived from Sargassum crassifolium taken from Garut waters and extracted with dilute HCl, tested for anti-inflammatory activity through inhibition of ICAM-1 and VCAM-1 using lipopolysaccharide-induced RAW 264.7 cell models. The viability test was carried out in the concentration range of 0.49-1000 µg / mL. The pattern of inhibition of cell proliferation is influenced by concentration. The highest concentration that caused cell viability of 80% was the concentration of 86.46μg / ml. Crude fukoidan reduced ICAM-1 and VCAM-1 levels at concentrations of 50 and 25 μg / ml.. Percent inhibition of ICAM-1 at 50 µg / mL concentration was 61.04% compared to control and 74.26% at 25 µg / mL concentration. While the percent inhibition of VCAM-1 a

Skrining Virtual dan Elusidasi Moda Ikatan Senyawa dalam Bawang Putih (Allium Sativum L.) sebagai Penghambat Reseptor Advanced Glycation end Products Esti Mulatsari; Esti Mumpuni; Ikhsan Ramadhan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Diabetic has long-term effects such as atherosclerosis, nephropathy, and retinopathy caused by the formation of Advanced Glycation End Products (AGEs). In vitro studies on garlic extract (Allium sativum L.) have been carried out on the inhibition activity of AGEs formation, but inhibitory mechanisms and which active compounds are involved in these activities are unknown. This study aims to do a virtual screening of garlic compounds (Allium sativum L.) on Advanced Glycation Endproduct receptors so that active compounds can be considered as candidates for drug compounds. The method used is molecular docking with PLANTS, YASARA, MarvinSketch software, and visualization of test compound bonds on receptor amino acids using PyMOL. Pyridoxamine and Aminoguanidine as a positive control of AGEs inhibitors. The docking results of 24 test compounds obtained seven compounds that active in inhibiting 3B75 receptor and five compounds in 3O3U receptor. Candidates for drug compounds consist of organosulfur, phenols and flavonoids. Ɣ-glutamyl-cysteine, E-ajoene, Nα- (1-Deoxy-Dfructose-1-YL) -L-Arginine, Kaempferol-3-o-β-D-glucopyranose, and Iso-rhamnetin-3-o-β -D-glucopyranose are compounds in garlic which have an ability to inhibit 3B75 and 3O3U receptors and predicted have better activity than pyridoxamine and aminoguanidine.

Formulasi dan Evaluasi Larutan Pencuci Mulut dengan Bahan Antimikroba Senyawa 1,5-Bis (3’-Etoksi-4’-Hidroksifenil)-1,4-Pentadien-3-on Esti Mumpuni; Agus Purwanggana; Esti Mulatsari; Ryan Pratama
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

1,5-bis (3-ethoxy-4-hydroxyphenyl) -1,4-pentadien-3-one (EHP) compound is an analogous compound of curcumin which has antimicrobial activity. In this study, the formulation and evaluation of mouthwash was carried out with EHP as an antimicrobial ingredient. The formulation of mouthwash was made with various concentrations of EHP 3, 6, 12, 16 and 18 ppm. Evaluation of mouthwash included organoleptic test, pH, clarity, density and antimicrobial activity against Staphylococcus aureus, Steptococcus mutans, and Candida albicans. Antimicrobial test was done by agar diffusion method. The results of organoleptic test obtained mouthwash was clear blue liquid, the aroma of mint, and fresh cold taste; pH range of 6.15 - 6.74; density of 1.0419 - 1.0561 g/cm3. The evaluation of mouthwash showed that the mouthwash was stable in storage for 1 month at 40 °C. Antimicrobial tests showed the diameter of inhibitory zone against Staphylococcus aureus (ATCC 6538); Streptococcus mutans (ATCC 31987) and Candida albicans (ATCC 10231) ranged from 6.2 to 8.4 mm at the concentration of EHP 18 bpj. The results showed that EHP compound was potential as antimicrobial ingredient in moutwash formula.

Aktivitas Senyawa Sargassum sp. sebagai Anti-aterosklerosis dengan Pembandingan Ligan-Reseptor HMG-CoA Reduktase- Simvastatin (1HW9) dan Uji Toksisitas secara In-Silico Sarah Zaidan; Syamsudin Abdillah; Deni Rahmat; Ratna Djamil; Esti Mumpuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Introduction:Sargassum.sp is one of the marine biota published as antiaterosclerosis, but compound toxicity data need to be explored for safety. Method: Virtual screening has been done with MVD software from active compounds contained in sargassum where has activity as antiaterosclerosis with the mechanism of hypolipidemic effects. Test compounds in sargassum include: fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol, phlorotannin, with HMG-COA Reductase-Simvastatin adenosine receptors with a 1HW9 /PDB code. Its toxicity is predicted using pkCSM (online). Results: The value RS, RMSD value as a result of the docking simulation carried out on said compounds, the following results are obtained: fucoidan (-110,420; 1,478), rhamnose (-72,081; 1,629), fucose (-98,408; 1,546), galactose (-95,757; 5,187), fucoxantin (-106,297; 2,161), alginate (-84,674; 2,897), phlorofucofuroeckol A (-106.701; 2,809), phloroglucinol (-103,140; 2,142), phlorotannin (-48,826; 7,750). The prediction results of toxicity showed fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol and phlorotannin not toxic with LD50 0.95-2.482g / kg. Conclusion:Based on RS values, fucoidan, fucoxantin and phlorofucofuroeckol A compounds contained in brown seaweed were predicted to have activity as antiaterosclerosis. Compounds in brown seaweed can also be predicted to be relatively non-toxic with a value of LD50 0.95-2.482g / kg.

Docking Molekular dari Trigonella foenum-graceum sebagai Antidiabetes menggunakan Molegro Virtual Docking Andri Prasetiyo; Esti Mumpuni; Raymond R. Tjandrawinata
Jurnal Jamu Indonesia Vol. 4 No. 2 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Trigonella foenum-graceum atau fenugreek digunakan secara luas sebagai obat tradisional untuk pengobatan diabetes tetapi mekanisme kerjanya masih belum jelas. Penelitian bertujuan memprediksi senyawa dalam fenugreek yang berkhasiat sebagai antidiabetes secara in-silico dengan menggunakan perangkat lunak Molegro Virtual Docking . Docking dilakukan 10 Senyawa uji dalam fenugreek yaitu 4-hidroxyisoleucine, coumarine, diosgenin, galactomannan, isovitexin, quarcetin, tigogenin, trigoneline, vitexin dan yamogenin dengan 3 reseptor yaitu sugar beet alpha-glucosidase- (PDB ID : 3W37), human dipeptidyl peptidase-4 (PDB ID : 1X70), human peroxisome proliferator activated gamma (PDB: 2PRG) serta senyawa pembanding acarbose, sitagliptin dan rosiglitazone. Dari 10 senyawa uji, galactomanann memiliki nilai Rerank Score/RS paling rendah di dua reseptor yaitu alpha glucosidase dan peroxisome proliferator activated gamma dengan nilai berturut turut -116.56 kcal/mol dan -131.18 kcal/mol dan nilai RS acarbose -113.60 kcal/mol dan rosiglitazone -124.54 kcal/mol . Dari 10 senyawa uji, tigogenin memiliki nilai RS paling rendah direseptor dipeptidyl peptidase-4 dengan nilai RS -86.54 kcal/mol dan nilai RS sitagliptin -87.02 kcal/mol. Berdasarkan nilai RS, galactomannan diprediksi memiliki aktivitas antidiabetes yang bekerja pada reseptor alpha-glucosidase dan peroxisome proliferator activated gamma sedangkan tigogenin diprediksi memiliki aktivitas antidiabetes yang bekerja pada reseptor dipeptidyl peptidase-4.

PELATIHAN VISUALISASI MOLEKUL KIMIA DENGAN SOFTWARE CHEMSKETCH UNTUK SISWA TINGKAT SEKOLAH MENENGAH ATAS Esti Mulatsari; Esti Mumpuni; Liliek Nurhidayati; Agus Purwanggana; Diah Kartika Pratami
Magistrorum et Scholarium: Jurnal Pengabdian Masyarakat Vol 2 No 1 (2021)
Publisher : Universitas Kristen Satya Wacana Salatiga

Senior High School (SMA) has a very broad scientific scope, one of which is chemistry. In chemistry, it presents the processes, chemical notations, types, and arrangements of matter. Chemical processes can be written in a concise form, such as a reaction equation, without eliminating the microscopic and macroscopic aspects that occur in the chemical process. This equation for the reaction is a symbolic aspect of chemistry. All the substances involved in the equation of the reaction are also symbolic aspects of chemistry. In other words, chemical formulas, such as atomic symbols, element symbols, compound symbols or formulas, all of these are symbolic aspects of chemistry. This symbolic aspect is of great importance in chemistry. Training on the use of ChemSketch software is very important for high school students, especially science majors, as an enrichment for chemistry subjects and improves skills in presenting chemical data in order to improve the quality of graduates. ChemSketch software provides process symbols, chemical notations, types, arrangement of materials, and several image representations of various laboratory tools, which are quite easy to use. Training on the use of ChemSketch for SMA N 13 Depok students has been enthusiastically carried out online, the material is relevant to chemistry subject matter, easy to accept and the delivery of the material is quite interesting.

Studi In Silico Senyawa Bioaktif pada Daun Yakon (Smallanthus sonchifolius), Kayu Secang (Caesalpinia sappan L.), Daun Salam (Syzygium polyanthum) Sebagai Antidiabetes Mekanisme Kerja Inhibitor SGLT-2 Andri Prasetyo Prasetyo; Esti Mumpuni; Sekar Harsti Rahmadhani; Saeful Amin
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39508

Diabetes melitus adalah penyakit metabolik yang ditandai dengan hiperglikemia dimana pankreas tidak memproduksi cukup insulin atau tubuh tidak dapat menggunakan insulin secara efektif. Daun yakon, kayu secang dan daun salam memiliki beberapa yang berpotensi sebagai antidiabetes, namun belum diketahui senyawa spesifik mana yang terlibat dalam mekanisme inhibitor SGLT-2. Penelitian ini bertujuan untuk menganalisis potensi senyawa bioaktif yang terkandung dalam Daun yakon, kayu secang dan daun salam dalam menghambat enzim SGLT-2 secara in silico. Data senyawa aktif didapatkan dari laman PubChem. Kristal struktur dari Structure of human SGLT2-MAP17 complex bound with empagliflozin didapatkan dari Protein Data Bank dengan PDB ID: 7VSI. Molecular docking menggunakan Molegro Virtual Docker dan simulasi molecular dynamic menggunakan YASARA Dynamics. Hasil molecular docking didapatkan 4 senyawa memiliki nilai rerank score lebih negative dari senyawa pembanding (empagliflozi). Hasil visualisasi menunjukan residu asam amino yang berperan penting ialah PHE 98 dan VAL 157. Hasil molecular dynamics menunjukan kompleks ligan memiliki kestabilan ikatan paling baik dan stabil dari ligan uji lainnya. Dihasilkan senyawa yang stabil, yaitu 3,4-Dicaffeoyquinic acid.

In Silico Studies: Stigmastan-3,6-dione in the Ethyl Acetate Fraction of Momordica charantia L Fruit has immunostimulant and anti-inflammatory activity Rachmi Ridho; Bambang Pontjo Priosoeryanto; Esti Mumpuni; Andri Prasetiyo; Syamsudin Abdillah
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.6865

Momordica charantia L fruit provides an immunomodulatory effect by stimulating certain components of the body's immune system. Bioactive phytochemicals from M. charantia L function as anti-inflammatory agents by reducing levels of pro-inflammatory cytokine secretion including IL-1, IL-6, IL-8, TNF-α, NF-kB. This research looks at the insilico mechanism of action of the active ingredient of the EtOAc fraction of M. charantia L fruit as an immunostimulant and anti-inflammatory. The materials and methods used were an Intel Core i7 10 Th Gen laptop, Chem Office Professional 17.1, Chem 2D, Chem 3D software, PDB code (6W9K) and ligand (TUA), Stigmastan-3,6 dione (C29H48O2) from the EtOAc fraction of fruit M. charantia L was docked using MVD software, RMSD and RMSF values were viewed using Yasara Software, pkCSM online tool to predict compound toxicity, toxicity prediction (LD50) was used by Protox online tool. The results of molecular docking of standard compounds, namely Methylprednisolone and Prednisolone and Stigmastan-3,6-dione, have Rerank Score values of -120.62, -121.47, -79.50, respectively. The lower the Rerank score value, the lower the binding energy between the protein and the ligand, causing the protein and ligand bonds to be more stable and it is predicted that the activity of the compound will be greater. The movement of RMSD values between 0.6-1.9 Å for the 3 (three) compounds, is still within stable limits and does not undergo conformation. The RMSF value of the 3 (three) compounds has the same amino acid residue pattern. The insilico toxicity prediction for the 3 (three) compounds is still within safe limits. The EtOAc fraction of M. charantia L fruit with the active compound Stigmastan-3,6-Dione in its mechanism of action in silico shows activity as an anti-inflammatory and immunostimulant that works on the NF-kB pathway.

Co-Authors Agus Purwanggana Andri Prasetiyo Ayu Werawati Bambang Pontjo Priosoeryanto Deni Rahmat Diah Kartika Pratami Dian Ratih Laksmitawati Ikhsan Ramadhan Kusmardi Kusmardi Liliek Nurhidayati Mulatsari, Esti Rachmi Ridho Ratna Djamil Raymond R. Tjandrawinata Ryan Pratama Saeful Amin Sarah Zaidan Sekar Harsti Rahmadhani Siti Marsha Dyah Kusumaningtyas Syamsudin Abdillah

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