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NINA ARTANTI
LEMBAGA ILMU PENGETAHUAN INDONESIA
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Pengembangan Getah Pepaya, Ekstrak Pepaya (Carica papaya L.) dan Ekstrak Umbi Bengkuang (Pachyrrhizus erosus (L.) Urb.) untuk Lotion Pencerah Kulit Berdasar Aktivitas Antioksidan dan Inhibisi Tirosinase LEONARDUS BROTO SUGENG KARDONO; LIANDHAJANI LIANDHAJANI; NINA ARTANTI; YETI MULYATI ISKANDAR; SITI MASRURAH BROTO SUTARYO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Whitening or skin lightening products are well known as cosmetic. In this development, papaya latex (Carica papaya L.), papaya fruit extract and yam bean tuber extracts (Pachyrrhizus erosus (L.) Urb.) were combined for skin lightening body lotion formula. Antioxidant and tyrosinase inhibitory activities were evaluated in the starting materials and the products. Antioxidant activity evaluation was conducted using DPPH free radical scavenging activity method. Tyrosinase inhibitory evaluation was performed based on tyrosinase enzymatic inhibitory reaction to tyrosine as substrate. Papaya latex showed the highest antioxidant activity (32.01%), followed by yam bean tuber extract (27.04%) and papaya extract (26.09%). The tyrosinase inhibitory activities of papaya latex, papaya fruit extract and yam bean tuber extracts were 68.42 %, 36.80% and 52.63 % respectively, as compared to that of arbutin (100%). Based on product appearance, color, odor, pH and viscosity, the product were stable for 128 weeks. The expired date calculation on its antioxidant activity, however, the product was stable for 77 weeks. It is recommended that the product should be stored in non transparent bottle at low temperature or at about 25-28oC.
Identifikasi Senyawa dari Ekstrak Air Rimpang Bangle (Zingiber cassumunar Roxb.) SRI HARTATI; MEGAWATI MEGAWATI; NINA ARTANTI; MEILYAWATI L.; M. HANAFI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.458 KB)

Abstract

In a preliminary study on search of marker compounds from raw material phytopharmaceutical water extracts of medicinal herbs bangle (Zingiber casumunar Roxb.) three compounds, namely (E)-4-(3’,4’-dimethoxyphenyl)but-3-en-1-yl acetate (1), (E)-4(3’,4’-dimethoxyphenyl) but-3-en-1-1-ol (2) and 2-Methoxy-8-(3,4-dimethoxyphenyl)-1,4-napthoquinone (3) had been found. The isolation was done by partition and combination of chromatography techniques. The isolated pure compound was analyzed by spectroscopy methods of NMR proton and carbon one and two-dimensional, LC-MS and IR-spectrophotometry IR
Co-Authors LEONARDUS BROTO SUGENG KARDONO LIANDHAJANI LIANDHAJANI M. HANAFI MEGAWATI MEGAWATI MEILYAWATI L. SITI MASRURAH BROTO SUTARYO SRI HARTATI YETI MULYATI ISKANDAR