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All Journal Riau Journal of Empowerment Jurnal Ilmu Kefarmasian Indonesia
Shella Anggraini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Uji Toksisitas Subkronis Ekstrak Etanol Daun Pucuk Merah (Syzygium Myrtifolium Walp.) Terhadap Fungsi Hati Dan Ginjal Syilfia Hasti; Rahmayati Rusnedy; Musdalifah Musdalifah; Asnila Asnila; Lisa Renita; Ferelina Santi; Shella Anggraini; Novia Sinata
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1103

Abstract

For the development of natural medicines from the ethanolic extract of Syzygium myrtifolium Walp leaves it is necessary to know the pre-clinical safety test so that its safety if used in the long term. The subchronic toxicity test of the ethanolic extract of Syzygium myrtifolium Walp leaves l was carried out by assessing the kidney and liver function of the test animals given after 60 days of test preparation, in the form of blood biochemical examination using the Mindray®BA-88A device and histological examination of the kidneys and liver. The results showed that the administration of ethanol extract of Syzygium myrtifolium Walp leaves at doses of 300, 600 and 900 mg/kgBW did not significantly affect the activity of SGOT, SGPT, serum creatinine levels (p>0.05). Microscopically on the percentage of damage to the glomerulus of the right and left kidneys. at doses of 600 and 900 mg/kgBW there was a significant difference to the control group (p<0.05). For qualitative microscopic examination, namely observation of sinusoids and hepatocyte cells at each level, there were abnormal changes. Meanwhile, quantitative microscopic examination at doses of 600 and 900 mg/kgBW caused an increase in the percentage of central vein damage (p<0.05). From the research, it was found that the ethanolic extract of Syzygium myrtifolium Walp leaves of white mice was safe for liver and kidney function at a dose of 300 mg/kgBW, but the doses group of 600 and 900 mg/kgBW gave a toxic effect on the kidneys and liver when compared to the control group.
Optimalisasi Pencegahan Balita Stunting Melalui Penyuluhan Dan Pelatihan Pada Kader Di Desa HangTuah, Kec. Perhentian Raja, Kab. Kampar Suyanto Suyanto; Dedi Afandi; Sri Wahyuni; Zulharman Zulharman; Ridha Restila; M. Alif Dzakwan; Shella Anggraini; Puan Justitia Azzahra; Muhammad Firdaus Eriyan; Daniel Darmawan; Hana Maysa; Nurfifi Pratiwi BDM; Julia Fitra; Ersa Fimadani; Rintan Dwi Putri
Riau Journal of Empowerment Vol 7 No 1 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/raje.7.1.50-63

Abstract

Stunting is a chronic nutritional disorder that causes children's height growth to be inappropriate for their age. This linear growth disorder is caused by a chronic lack of nutritional intake, especially during the First 1000 Days of Life (HPK) which starts from the time of conception until the child is 2 years old and/or due to repeated chronic infections. The factor of poor nutritional intake during pregnancy is related to the baby's low birth weight so that the baby can experience malnutrition from the womb until birth. The aim of the activity is to optimize the prevention of stunting in toddlers through counseling and training for cadres in Desa Hangtuah, Kec. Perhentian Raja, Kab. Kampar. The methods used are discussion, compression and simulation starting from the preparation stage, creating educational media such as posters and banners, counseling and simulating the use of anthropometric kits. The results obtained from activities can increase participants' knowledge and skills. It is hoped that with this activity participants can pass on the information obtained to other Hangtuah Village communities so that they can prevent stunting as early as possible.
Co-Authors Asnila Asnila Daniel Darmawan Dedi Afandi Ersa Fimadani Ferelina Santi Hana Maysa Julia Fitra Lisa Renita M. Alif Dzakwan Muhammad Firdaus Eriyan Musdalifah Musdalifah Nurfifi Pratiwi BDM Puan Justitia Azzahra Ridha Restila Rintan Dwi Putri Rusnedy, Rahmayati Sinata, Novia Sri Wahyuni Suyanto Suyanto Syilfia Hasti Zulharman Zulharman