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All Journal Jurnal Ilmu Kefarmasian Indonesia
HANIF NASIATUL BAROROH
UNIVERSITAS JENDRAL SOEDIRMAN
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Aktivitas Fraksi Protein Jatropa curcas Sebagai Antikanker Terhadap Ekspresi p53 pada Kulit Mencit Pasca Pemaparan DMBA dan UVB HANIF NASIATUL BAROROH; WARSINAH WARSINAH; HARWOKO HARWOKO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 2 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1257.761 KB)

Abstract

Efek Toksisitas Subakut Ekstrak Etanolik Daun Jambu Biji (Psidium guajava) pada Lambung Tikus Wistar Esti Dyah Utami; Hanif Nasiatul Baroroh; Nuryanti Nuryanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.016 KB) | DOI: 10.35814/jifi.v16i1.466

Abstract

Psidium guajava leaves have been proven be antiallergic. From the results of previous research, the ethanol extract of leaves is included in the class materials "Practically Non-Toxic." However, repeated administration may cause toxic effects on body organs, one of which was gaster. Subchronic toxicity had been carried out on 20 male Wistar rats and 20 female wistar albino rats. The test materials were administered orally, every day for 28 days. There are 3 (three) doses of test materials which were 250 mg, 500 mg, and 750 mg/kg BW. Observation of the general toxic effect was performed everyday, then organ sampling was performed on day 29 to examined gaster histology and score using Barthel-Manja methods. The result showed that administration of Psidium guajava leaves extract for 28 days caused physical and behavioral changes, caused soft and mucous feces, and also respiratory disorder. But the extract at dose 250 mg, 500 mg and 750 mg/kg BW did not caused changes on gaster histology profile and score. In conclusion, the extract did not have subchronic toxicity effect on gaster rat, but might caused general toxic effect in the higher dose.
Co-Authors Esti Dyah Utami HARWOKO HARWOKO Nuryanti Nuryanti WARSINAH WARSINAH