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Nuryanti Nuryanti
UNIVERSITAS JENDRAL SOEDIRMAN
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Pengembangan Formulasi Pasta Antiinflamasi Piroksikam Berbasis Ampas Tahu dalam Pemanfaatan Limbah Tahu Di Purwokerto Nita Triana Sari; Putri Dewi Riayah; Nabila Fasya; Ainul Mardziyati A; Namira Fadhilah B; Nuryanti Nuryanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (919.432 KB) | DOI: 10.35814/jifi.v15i2.505

Abstract

The soybean curd residue is the waste product of soybean. It has potential for being excipients in pharmaceutical preparations because of its high carbohydrate element. This study aims to evaluate the soybean curd residue as excipients of piroxicam antiinfl ammatory paste. The excipient of soybean curd residue is made by isolating it with 0.1% KOH, then being characterized by physical, chemical, and functional test after becoming starch. It was prepared in piroxicam antiinfl ammatory paste preparations with ratio of soybean curd residue starch and manihot strach are F1 (0:0.25), F2 (0.25:0), F3 (1.25:1.25), F4 (1.5:1), and F5 (1:1.5). The result of physical and freeze-thaw stability test were analyzed descriptively. The data of viscosity, stickiness, and spreading power test were analyzed using one-way ANOVA. Soybean curd residue starch’s physic is slightly coarse, cubic-shapes powder, uneven surface and nonporous, slightly hygroscopic, and brownish-white. It has distinctive odor and has no taste. Chemical test showed that it contained carbohydrate and had pH 4.9. Functional test showed on average 15% it has viscosity 1959 cps, fl ow time 6.7 seconds and still angle 39.2o. Results of physical and stability tests showed that F3 were the best piroxicam antiinfl ammatory paste formula.
Efek Toksisitas Subakut Ekstrak Etanolik Daun Jambu Biji (Psidium guajava) pada Lambung Tikus Wistar Esti Dyah Utami; Hanif Nasiatul Baroroh; Nuryanti Nuryanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.016 KB) | DOI: 10.35814/jifi.v16i1.466

Abstract

Psidium guajava leaves have been proven be antiallergic. From the results of previous research, the ethanol extract of leaves is included in the class materials "Practically Non-Toxic." However, repeated administration may cause toxic effects on body organs, one of which was gaster. Subchronic toxicity had been carried out on 20 male Wistar rats and 20 female wistar albino rats. The test materials were administered orally, every day for 28 days. There are 3 (three) doses of test materials which were 250 mg, 500 mg, and 750 mg/kg BW. Observation of the general toxic effect was performed everyday, then organ sampling was performed on day 29 to examined gaster histology and score using Barthel-Manja methods. The result showed that administration of Psidium guajava leaves extract for 28 days caused physical and behavioral changes, caused soft and mucous feces, and also respiratory disorder. But the extract at dose 250 mg, 500 mg and 750 mg/kg BW did not caused changes on gaster histology profile and score. In conclusion, the extract did not have subchronic toxicity effect on gaster rat, but might caused general toxic effect in the higher dose.
Co-Authors Ainul Mardziyati A Esti Dyah Utami HANIF NASIATUL BAROROH Nabila Fasya Namira Fadhilah B Nita Triana Sari Putri Dewi Riayah